Translocation of tetrahedral DNA nanostructures through a solid-state nanopore
Source abstract
Abstract
Tetrahedral DNA nanostructures (TDNs) are programmable DNA nanostructures that have great potential in bio-sensing, cell imaging and therapeutic applications. In this study, we investigate the translocation behavior of individual TDNs through solid-state nanopores. Pronounced translocation signals for TDNs are observed that are sensitive to the size of the nanostructures. TDNs bound to linear DNA molecules produce an extra signal in the ionic current traces. Statistical analysis of its relative temporal position reveals distinct features between TDNs bound to the end and those bound to the middle of the linear DNA molecules. A featured current trace for two TDNs bound to the same linear DNA molecule has also been observed. Our study demonstrates the potential of using TDNs as sensitive bio-sensors to detect specific segments of a single DNA molecule in real time, based on solid-state nanopore devices.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Advanced biosensing and bioanalysis techniques · Nanopore and Nanochannel Transport Studies · RNA Interference and Gene Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Beijing National Laboratory for Condensed-Matter Physics and Institute of Physics
Chinese Academy of Sciences
Beijing 100190
China
School of Physical Sciences
Beijing Normal University
100000 Beijing
School of Chemistry and Chemical Engineering
and Institute of Molecular Medicine
Renji Hospital
School of Medicine
Shanghai Jiao Tong University
Division of Physical Biology and Bioimaging Center
Shanghai Synchrotron Radiation Facility
CAS Key Laboratory of Interfacial Physics and Technology
Shanghai Institute of Applied Physics
Funding
National Natural Science Foundation of China · Chinese Academy of Sciences · Natural Science Foundation of Beijing Municipality
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