Slowing the translocation of single-stranded DNA by using nano-cylindrical passage self-assembled by amphiphilic block copolymers
Source abstract
Abstract
We report a novel approach to slow the translocation of single-stranded DNA (ssDNA) by employing polyethylene oxide (PEO) filled nano-cylindrical domains as transportation channels. DNA strands were demonstrated to electrophoretically translocate through PEO filled cylindrical domains with diameters of 2 and 9 nm, which were self-assembled by amphiphilic liquid crystalline block copolymers. The average translocation rate of ssDNA strands was effectively reduced to an order of 10 μs per nucleotide, which was 1-2 orders slower than that attained by utilizing conventional solid-state nanopore devices.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanopore and Nanochannel Transport Studies · RNA Interference and Gene Delivery · Electrostatics and Colloid Interactions
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (39)
Show source-provided references
1. Dekker · Nat. Nanotechnol. · 2007 · 2 · 20910.1038/nnano.2007.27 ↗
2. Branton · Nat. Biotechnol. · 2008 · 26 · 114610.1038/nbt.1495 ↗
3. Wanunu · Phys. Life Rev. · 2012 · 9 · 12510.1016/j.plrev.2012.05.010 ↗
4. Jonsson · Nano Lett. · 2013 · 13 · 102910.1021/nl304213s ↗
5. Ohshiro · Sci. Rep. · 2012 · 2 · 50110.1038/srep00501 ↗
6. Xie · Nat. Nanotechnol. · 2012 · 7 · 11910.1038/nnano.2011.217 ↗
7. Manrao · Nat. Biotechnol. · 2012 · 30 · 34910.1038/nbt.2171 ↗
8. Ayub · Nano Lett. · 2012 · 12 · 563710.1021/nl3027873 ↗
9. Cherf · Nat. Biotechnol. · 2012 · 30 · 34410.1038/nbt.2147 ↗
10. Laszlo · Nat. Biotechnol. · 2014 · 32 · 82910.1038/nbt.2950 ↗
11. Venta · ACS Nano · 2013 · 7 · 462910.1021/nn4014388 ↗
12. Xie · Nat. Nanotechnol. · 2012 · 7 · 11910.1038/nnano.2011.217 ↗
13. Venkatesan · Nat. Nanotechnol. · 2011 · 6 · 61510.1038/nnano.2011.129 ↗
14. Akahori · Nanotechnology · 2014 · 25 · 27550110.1088/0957-4484/25/27/275501 ↗
15. Fologea · Nano Lett. · 2005 · 5 · 173410.1021/nl051063o ↗
16. Mirsaidov · Nanotechnology · 2010 · 21 · 39550110.1088/0957-4484/21/39/395501 ↗
17. Kowalczyk · Nano Lett. · 2010 · 10 · 141410.1021/nl100271c ↗
18. Wanunu · Biophys. J. · 2008 · 95 · 471610.1529/biophysj.108.140475 ↗
19. Singer · J. Phys.: Condens. Matter · 2010 · 22 · 454111
20. Wanunu · Nat. Nanotechnol. · 2010 · 5 · 16010.1038/nnano.2009.379 ↗
21. Goto · Sci. Rep. · 2015 · 5 · 1664010.1038/srep16640 ↗
22. Waugh · Electrophoresis · 2015 · 36 · 175910.1002/elps.201400488 ↗
23. Anderson · ACS Nano · 2013 · 7 · 140810.1021/nn3051677 ↗
24. Larkin · ACS Nano · 2013 · 7 · 1012110.1021/nn404326f ↗
25. Feng · Nat. Nanotechnol. · 2015 · 10 · 107010.1038/nnano.2015.219 ↗
26. Rosenstein · Nat. Methods · 2012 · 9 · 48710.1038/nmeth.1932 ↗
27. I. W. Hamley , The Physics of Block Copolymers, Oxford Press, 1996
28. Tian · Macromolecules · 2002 · 35 · 373910.1021/ma011859j ↗
29. Komura · Macromolecules · 2015 · 48 · 67210.1021/ma5018742 ↗
30. Komiyama · Macromolecules · 2014 · 47 · 177710.1021/ma402356z ↗
31. Yoon · J. Phys. Chem. B · 2008 · 112 · 848610.1021/jp803664h ↗
32. Yamamoto · Adv. Funct. Mater. · 2011 · 21 · 91810.1002/adfm.201002069 ↗
33. Larkin · ACS Nano · 2013 · 7 · 1012110.1021/nn404326f ↗
34. Meller · Electrophoresis · 2002 · 23 · 258310.1002/1522-2683(200208)23:16<2583::AID-ELPS2583>3.0.CO;2-H ↗
35. Jin · ACS Nano · 2016 · 10 · 343510.1021/acsnano.5b07511 ↗
36. Kwok · PLoS One · 2014 · 9 · e9288010.1371/journal.pone.0092880 ↗
37. Yanagi · Sci. Rep. · 2014 · 4 · 500010.1038/srep05000 ↗
38. Yi · Adv. Mater. · 2012 · 24 · 310710.1002/adma.201200265 ↗
39. Ruiz · Science · 2008 · 321 · 93610.1126/science.1157626 ↗