journal article·2019

Atomic force microscopy-based single-molecule force spectroscopy detects DNA base mismatches

Wenjing Liu, Yourong Guo, Kaizhe Wang, Xingfei Zhou, Ying Wang, Junhong Lü, Zhifeng Shao, Jun Hu, Daniel M. Czajkowsky, Bin Li

Nanoscale· Volume 11· Issue 37
Publisher page

Abstract

AFM-based single-molecule-force spectroscopy is limited by low throughput. We introduce addressable DNA origami to study multiple target molecules at once. Target DNAs differing by only a single-base pair mismatch are clearly differentiated.
Only a short abstract or summary was supplied by the source.
Source: crossref · Quality: short

Research context

OpenAlex topics: Force Microscopy Techniques and Applications · Advanced biosensing and bioanalysis techniques · Molecular Junctions and Nanostructures

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Shanghai Institute of Applied Physics

Chinese Academy of Sciences

Shanghai 201800

China

University of Chinese Academy of Sciences

Bio-ID Center

School of Biomedical Engineering

Shanghai Jiao Tong University

Shanghai

School of Science

Ningbo University

Ningbo 315211

Zhangjiang Laboratory

Funding

National Natural Science Foundation of China · Chinese Academy of Sciences

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