Wound dressing applications of electrospun nanofibers: mechanism, construction and recent progress
Source abstract
Abstract
Wounds are prevalent health concerns, and their complex, dynamic healing process presents ongoing challenges in clinical practice. Wound dressings, which play an integral role in both acute and chronic wound management, are no longer limited to simple protection but are increasingly recognized for their active role in promoting healing. Among the most promising candidates in wound care is electrospun nanofiber dressing due to its ability to replicate the extracellular matrix, customizable structural features, and versatile functionality. This review highlights recent advances in electrospun nanofibers, focusing on their compositional modification and structural design, alongside their applications in wound healing. We begin by summarizing the key stages of wound healing, including cell migration, matrix remodeling, and angiogenesis, to underscore the biological processes driving repair. Following this, we briefly introduced the development history and basic principles of electrospinning. Then, we focused on summarizing recent progress in electrospun nanofiber dressing in drug delivery, biophysical stimulation for enhanced healing, and real-time wound monitoring. Finally, we address the challenges and future directions in the development of smart wound dressings, emphasizing their potential to revolutionize wound management practices.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Wound Healing and Treatments · Silk-based biomaterials and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
College of Light Industry & Textiles, Inner Mongolia University of Technology, Hohhot 010051, PR China
College of Chemical Engineering, Inner Mongolia University of Technology, Hohhot 010051, PR China
State Key Laboratory of Bioinspired Interfacial Materials Science, Laboratory of Bio-inspired Smart Interfacial Science and Technology of Ministry of Education, Beijing 100191, PR China
Advanced Innovation Center for Biomedical Engineering, School of Chemistry, Beihang University, Beijing 100191, PR China
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an 710032, PR China
Department of Plastic Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, PR China
Funding
National Natural Science Foundation of China · Natural Science Foundation of Beijing Municipality · Natural Science Foundation of Inner Mongolia Autonomous Region · Inner Mongolia Autonomous Region
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