journal article·2025

A high-contrast NIR excitation probe for monitoring Cu 2+ in the endoplasmic reticulum for synergistic cuproptosis and ferroptosis anticancer therapy

Jingjing Jiang, Qiong Zhang, Yue Zhang, Lintong Gao, Yan Feng, Xianshun Sun, Junjun Wang, Xiaojiao Zhu, Xingxing Chen, Hongping Zhou

Nanoscale· Volume 17· Issue 5
Publisher page

Abstract

Currently, the study of cuproptosis focuses on the Cu2+-induced morphology changes in mitochondria (Mito), and the observation of the effect of endoplasmic reticulum (ER)-related Cu2+ content on cuproptosis is relatively lacking. Herein, we have developed a hydroxyflavone (HF)-based NIR excited two-photon fluorescent probe, BHCO, that exhibits specific recognition of Cu2+ with high resolution. BHCO-Cu2+ (Cu2BC) can lead to DLAT protein aggregation, triggering cuproptosis. Furthermore, Cu2BC can upregulate reactive oxygen species (ROS) under 720 nm excitation, which facilitates ferroptosis. The synergistic effect of ferroptosis and cuproptosis leads to the damage of cellular mitochondria and endoplasmic reticulum, resulting in the severe death of cancer cells. We are firmly convinced that our nonlinear optical (NLO) small molecule probe for monitoring Cu2+ could provide a valid tool for rapid tumor elimination through synergistic ferroptosis and cuproptosis.
Source: europepmc · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Trace Elements in Health · Nanoparticle-Based Drug Delivery · Advanced Nanomaterials in Catalysis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Chemistry and Chemical Engineering, Center of Free Electron Laser & High Magnetic Field, Key Laboratory of Structure and Functional Regulation of Hybrid Materials Ministry of Education, Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, and Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials of Anhui Province, Anhui University, P.R. China

School of Chemical and Environmental Engineering, Anhui Polytechnic University, 241000, Wuhu, P.R. China

Funding

National Natural Science Foundation of China · Anhui Department of Education · Natural Science Foundation of Anhui Province · Anhui University · China Postdoctoral Science Foundation

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