Nanoparticle-protein corona enhances accuracy of Ca-19.9-based pancreatic cancer classification
Source abstract
Abstract
= 106 donors significantly improved the ability to differentiate between non-oncological and PDAC patients (up to 92%), also boosting the classification of PDAC subjects by 50% compared to CA 19-9 testing alone. Overall, this study sought to bridge the existing gaps in PDAC detection by exploiting the complementary strengths of conventional biomarkers and cutting-edge nanotechnology. Exploration of this combined strategy holds promise for advancing the early detection of PDAC, ultimately contributing to improved patient prognosis and treatment outcomes.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Pancreatic and Hepatic Oncology Research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
NanoDelivery Lab, Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena, 291, 00161 Rome, Italy
Research Unit of General Surgery, Department of Medicine and Surgery, University Campus Bio-Medico di Roma, Rome, Italy
Operative Research Unit of General Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy
Institute of Inorganic Chemistry, Graz University of Technology, 8010 Graz, Austria
Funding
Fondazione AIRC per la ricerca sul cancro ETS
References (40)
Show source-provided references
1. Bray · CA-Cancer J. Clin. · 2018 · 68 · 39410.3322/caac.21492 ↗
2. Siegel · CA Cancer J. Clin. · 2021 · 71 · 710.3322/caac.21654 ↗
3. Lee · World J. Gastrointest. Surg. · 2020 · 12 · 46810.4240/wjgs.v12.i12.468 ↗
4. Koprowski · Somatic Cell Genet. · 1979 · 5 · 95710.1007/BF01542654 ↗
5. Azizian · Sci. Rep. · 2020 · 10 · 133210.1038/s41598-020-57930-x ↗
6. S.Scarà , P.Bottoni and R.Scatena , CA 19-9: biochemical and clinical aspects , in Advances in Cancer Biomarkers: From Biochemistry to Clinic for a Critical Revision , 2015 , pp. 247–26010.1007/978-94-017-7215-0_15 ↗
7. George · Front. Oncol. · 2021 · 11 · 75468710.3389/fonc.2021.754687 ↗
8. Coppola · Front. Oncol. · 2021 · 11 · 69058010.3389/fonc.2021.690580 ↗
9. A.Dasgupta and A.Wahed , Clinical chemistry, immunology and laboratory quality control: a comprehensive review for board preparation, certification and clinical practice , 2013
10. Luo · Biochim. Biophys. Acta, Rev. Cancer · 2021 · 1875 · 18840910.1016/j.bbcan.2020.188409 ↗
11. Digiacomo · Cancers · 2023 · 15 · 298310.3390/cancers15112983 ↗
12. O'Neill · World J. Gastroenterol. · 2021 · 27 · 404510.3748/wjg.v27.i26.4045 ↗
13. Kopac · Int. J. Biol. Macromol. · 2021 · 169 · 29010.1016/j.ijbiomac.2020.12.108 ↗
14. Cedervall · Proc. Natl. Acad. Sci. U. S. A. · 2007 · 104 · 205010.1073/pnas.0608582104 ↗
15. Lundqvist · Proc. Natl. Acad. Sci. U. S. A. · 2008 · 105 · 1426510.1073/pnas.0805135105 ↗
16. Mahmoudi · Nat. Rev. Mater. · 2023 · 1
17. Hajipour · Biomater. Sci. · 2014 · 2 · 121010.1039/C4BM00131A ↗
18. Hajipour · Nanoscale · 2015 · 7 · 897810.1039/C5NR00520E ↗
19. Quagliarini · Nano Today · 2022 · 47 · 10165710.1016/j.nantod.2022.101657 ↗
20. Colapicchioni · Int. J. Biochem. Cell Biol. · 2016 · 75 · 18010.1016/j.biocel.2015.09.002 ↗
21. Quagliarini · J. Nanobiotechnol. · 2023 · 21 · 26710.1186/s12951-023-02030-x ↗
22. Di Santo · Front. Bioeng. Biotechnol. · 2020 · 8 · 49110.3389/fbioe.2020.00491 ↗
23. Quagliarini · Sens. Int. · 2020 · 1 · 10002510.1016/j.sintl.2020.100025 ↗
24. S. C.Ray , Application and uses of graphene oxide and reduced graphene oxide , in Applications of Graphene and Graphene-Oxide based Nanomaterials , 2015 , vol. 6 , pp. 39–5510.1016/B978-0-323-37521-4.00002-9 ↗
25. Kumar · Commun. Chem. · 2020 · 3 · 810.1038/s42004-019-0254-9 ↗
26. Papi · Nanoscale · 2019 · 11 · 1533910.1039/C9NR01413F ↗
27. Land · Nat. Microbiol. · 2019 · 4 · 4610.1038/s41564-018-0295-3 ↗
28. Luo · Pancreatology · 2016 · 16 · 105710.1016/j.pan.2016.09.013 ↗
29. Liu · Int. J. Cancer · 2012 · 131 · 68310.1002/ijc.26422 ↗
30. Al-Shaheri · Cancer Treat. Rev. · 2021 · 96 · 10219310.1016/j.ctrv.2021.102193 ↗
31. Zhang · World J. Surg. Oncol. · 2020 · 18 · 110.1186/s12957-019-1767-5 ↗
32. Sopotnik · Carbon · 2015 · 95 · 56010.1016/j.carbon.2015.08.018 ↗
33. Digiacomo · Biointerphases · 2021 · 16 · 01101010.1116/6.0000540 ↗
34. Caputo · Nanoscale · 2017 · 9 · 34910.1039/C6NR05609A ↗
35. Giulimondi · Part. Part. Syst. Charact. · 2023 · 40 · 220016910.1002/ppsc.202200169 ↗
36. Castagnola · Nat. Commun. · 2018 · 9 · 157710.1038/s41467-018-04009-x ↗
37. Lin · Medicine · 2016 · 95 · e452710.1097/MD.0000000000004527 ↗
38. Nipp · Cancer Med. · 2018 · 7 · 52510.1002/cam4.1277 ↗
39. Digiacomo · Lab Chip · 2019 · 19 · 255710.1039/C9LC00341J ↗
40. Renzi · Nat. Commun. · 2024 · 15 · 911910.1038/s41467-024-53569-8 ↗