journal article·2024Open access

Synergistic effect of ROS-generating polydopamine on drug-induced bone tissue regeneration

Hyeju Han, Bongkyun Kang, Shazid Md. Sharker, Tabassum Binte Kashem, Yuejin Kim, Jeehee Lee, Minok Park, Eunjeong Kim, YunJae Jung, Jinkyu Lim, Seungwon Ryu, Kyueui Lee

Nanoscale· Volume 16· Issue 43

Abstract

A PHD (prolyl hydroxylase) inhibitor, 1,4-dihydrophenonthrolin-4-one-3-carboxylic acid (1,4-DPCA), is a drug that can artificially promote tissue regeneration by enhancing metabolic activity through the upregulation of hypoxia inducible factor 1 subunit alpha (Hif-1α) under normoxic conditions. This study presents a novel design methodology for a drug delivery system to maximize the regenerative effect of 1,4-DPCA. Specifically, by encapsulating 1,4-DPCA in polydopamine (PDA) that generates reactive oxygen species (ROS), the combined effects of Hif-1α upregulation and the induction of cellular antioxidant defense mechanisms by localized ROS can significantly enhance tissue regeneration. The study confirmed that each material (PDA and 1,4-DPCA) triggers a positive synergistic effect on the regenerative mechanisms. As a result, the use of a PDA drug delivery system loaded with 1,4-DPCA showed approximately six times greater bone regeneration compared to the control (no treatment) in a mouse calvarial defect model.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Bone Tissue Engineering Materials · Polymer Surface Interaction Studies · Electrospun Nanofibers in Biomedical Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry, Kyungpook National University, Daegu 41566, South Korea

KNU Institute of Basic Sciences and KNU G-LAMP Project Group, Kyungpook National University, Daegu 41566, South Korea

Department of Pharmaceutical Sciences, North South University, Dhaka 1229, Bangladesh

Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA

Energy Technologies Area, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA

BK21 FOUR KNU Creative BioResearch Group, Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu 41566, Republic of Korea

Department of Microbiology, Gachon University College of Medicine, Incheon 21999, South Korea

Department of Energy and Environmental Engineering, The Catholic University of Korea, Bucheon 14662, South Korea

Biomedical Research Institute, Kyungpook National University Hospital, Daegu 41940, South Korea

Funding

Korea Health Industry Development Institute · National Research Foundation of Korea · Korea Institute of Energy Technology Evaluation and Planning

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