Near-infrared AIEgens for sulfatase imaging in breast cancer in vivo
Source abstract
Abstract
Aggregation-induced emission luminogens (AIEgens) enable highly sensitive and in situ visualization of sulfatase to benefit the early diagnosis of breast cancer (BC), but current sulfatase AIEgens always emit visible light (<650 nm). Herein, a near-infrared (NIR) AIEgen QMT-SFA is developed for sulfatase imaging in vivo. Hydrophilic QMT-SFA is cleaved by sulfatase to yield hydrophobic QMT-OH, which subsequently aggregates into nanoparticles to turn the AIE fluorescence "on", enabling sensitive sulfatase imaging in 4T1 cells and mouse models.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Optical Imaging and Spectroscopy Techniques · Spectroscopy Techniques in Biomedical and Chemical Research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing, Jiangsu 210096, China
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu 210023, China
Handan Norman Technology Co., Ltd, Guantao 057750, China
Funding
National Natural Science Foundation of China · China Postdoctoral Science Foundation
References (19)
Show source-provided references
1. Loibl · Lancet · 2021 · 397 · 175010.1016/S0140-6736(20)32381-3 ↗
2. Giaquinto · CA Cancer J. Clin. · 2022 · 72 · 52410.3322/caac.21754 ↗
3. Barba · Crit. Rev. Oncol. Hematol. · 2021 · 157 · 10317410.1016/j.critrevonc.2020.103174 ↗
4. Kunkler · N. Engl. J. Med. · 2023 · 388 · 58510.1056/NEJMoa2207586 ↗
5. Yue · Chin. Chem. Lett. · 2018 · 29 · 64810.1016/j.cclet.2018.01.046 ↗
6. Hanson · Angew. Chem., Int. Ed. · 2004 · 43 · 573610.1002/anie.200300632 ↗
7. Mashima · Int. J. Mol. Sci. · 2022 · 23 · 815310.3390/ijms23158153 ↗
8. Xu · ACS Nano · 2022 · 16 · 1932810.1021/acsnano.2c08896 ↗
9. Wu · Chem. Soc. Rev. · 2022 · 51 · 45010.1039/D1CS00543J ↗
10. He · Nat. Biomed. Eng. · 2023 · 7 · 28110.1038/s41551-023-01009-1 ↗
11. Li · Sci. China: Chem. · 2020 · 63 · 1428
12. Xiang · ACS Sens. · 2023 · 8 · 202110.1021/acssensors.3c00201 ↗
13. Xu · J. Am. Chem. Soc. · 2023 · 145 · 2774810.1021/jacs.3c10255 ↗
14. Zhu · Adv. Mater. · 2022 · 34 · e210744410.1002/adma.202107444 ↗
15. Jia · CCS Chem. · 2022 · 4 · 50110.31635/ccschem.021.202101458 ↗
16. Qi · Aggregate · 2021 · 2 · 9510.1002/agt2.25 ↗
17. Xu · Chem. Eng. J. · 2022 · 428 · 13251410.1016/j.cej.2021.132514 ↗
18. Xu · Biosens. Bioelectron. · 2024 · 255 · 11620710.1016/j.bios.2024.116207 ↗
19. Shen · J. Am. Chem. Soc. · 2022 · 144 · 1539110.1021/jacs.2c07443 ↗