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journal article·2024Open access

H 2 O 2 -stimulated Janus-shaped self-propelled nanomotors as an active treatment for acute renal injury

Jun Xu, Yali Zhong, Weixin Wang, Rui Gao, Yini Wang, Fei Tong, Jiahui Sun, Miaofang Hong, Lingyan Qiao, Weiwei Qiao, Qibing Mei, Jianming Wu

Nanoscale· Volume 16· Issue 3
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Source abstract

Abstract

As emerging nanosystems, nanomotors have been applied in the active treatment of many diseases. In this paper, Pt@chitosan-loaded melatonin asymmetrical nanomaterials embedded with L-serine (S, kidney injury molecule 1-targeting agent) were constructed to alleviate acute kidney injury (AKI). The Janus nanocarriers arrived at the renal injury site via the bloodstream and exhibited high permeability. Because of melatonin distribution in the kidneys combined with H2O2-stimulated O2 release, the administration of the Janus nanosystem resulted in active treatment through the motion of nanomotors by asymmetrical O2 release.
Source: europepmc · Quality: candidate unverified · Source record ↗

Research context

Nanomaterials

OpenAlex topics: Micro and Nano Robotics · Hemoglobin structure and function · Cerebrospinal fluid and hydrocephalus

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Emergency, First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang Province, China

Southwest University of Science and Technology, Mianyang, 621000, China

College of Pharmacy, Binzhou Medical University, Yantai, 264003, PR China

School of Basic Medical Sciences, Zhejiang University Medicine, Hangzhou, 310000, PR China

Education Ministry Key Laboratory of Medical Electrophysiology, Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, Luzhou, China

Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy, Southwest Medical University, Luzhou, 646000, China

Funding

Department of Education of Zhejiang Province

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