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journal article·2025Open access

Smart polymer prodrugs via responsive prodrug-initiated ring-opening polymerization of lactide for improved drug delivery

Shiwei Fu, Miao Zhang, Nicholas Calzadilla, Bowen Zhao, Xiao Zhang, Bowei Yang, Victoria A. A. McKenzie, Ajay Zheng, Qianqian Ni, Fuwu Zhang

Nanoscale· Volume 17· Issue 17
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Source abstract

Abstract

Smart polymer prodrugs, created via responsive prodrug-initiated controlled polymerization of lactide, demonstrated extremely high drug loading, tuneable stimuli-triggered drug release, and significant tumor growth inhibition and improved survival with minimal toxicity. This adaptable strategy can precisely tailor drugs' physicochemical properties for optimal therapeutic efficacy, demonstrating great promise for cancer treatment.
Source: europepmc · Quality: candidate unverified · Source record ↗

Research context

Polymers

OpenAlex topics: biodegradable polymer synthesis and properties · Graphene and Nanomaterials Applications · Supramolecular Self-Assembly in Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, Florida, 33146, USA

Nanomedicine Translational Research Program, NUS Centre for Nanomedicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore

Clinical Imaging Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore

The Dr John T. Macdonald Foundation Biomedical Nanotechnology Institute, University of Miami, Miami, FL 33136, USA

Sylvester Comprehensive Cancer Centre, University of Miami Miller School of Medicine, Miami, Florida 33136, USA

Funding

University of Miami

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