journal article·2023Open access

Label-free detection of MiRNA biomarkers using broadband multi-resonant infrared metasurfaces for early breast cancer diagnosis

Shuyan Zhang, Qing Yang Steve Wu, Yi Fan Chen, Melissa Hum, Dave Chi Lok Wong, Ern Yu Tan, Ann Siew Gek Lee, Jinghua Teng, Dinish U.S, Malini Olivo

Nanoscale· Volume 15· Issue 23

Abstract

Squared value of up to 0.98. This study represents the first use of a SEIRA sensor for biomarker detection on clinical breast cancer samples and introduces an analysis method that produces results comparable to industry standards. Our findings pave the way for routine cancer diagnosis in the future. Additionally, the method discussed can be generalized to other biosensing activities involving two-step binding processes with complementary molecule-capturing agents.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Advanced biosensing and bioanalysis techniques · Photoacoustic and Ultrasonic Imaging · Plasmonic and Surface Plasmon Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Innovis #08-03, Singapore, 138634, Republic of Singapore

Division of Cellular and Molecular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre (NCC), 30 Hospital Boulevard, Singapore, 169610, Republic of Singapore

Chang Gung University, No. 259, Wenhua 1 st Rd, Guishan District, Taoyuan City, 333, Taiwan, Republic of China

Breast & Endocrine Surgery, Tan Tock Seng Hospital (TTSH), 11 Jln Tan Tock Seng, Singapore, 308433, Republic of Singapore

Lee Kong Chian School of Medicine, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Republic of Singapore

Funding

Agency for Science, Technology and Research · National Medical Research Council

References (31)

Show source-provided references
1. Arnold · Breast · 2000 · 66 · 1510.1016/j.breast.2022.08.010 ↗
2. Nelson · Ann. Intern. Med. · 2016 · 164 · 25610.7326/M15-0970 ↗
3. Ende · Int. J. Cancer · 2017 · 141 · 129510.1002/ijc.30794 ↗
4. Nelson · Ann. Intern. Med. · 2016 · 164 · 22610.7326/M15-0971 ↗
5. Li · Asia. Pac. J. Clin. Oncol. · 2022 · 69610.1111/ajco.13763 ↗
6. Ong · Health Aff. · 2015 · 34 · 57610.1377/hlthaff.2014.1087 ↗
7. Loke · Eur. J. Cancer · 2018 · 92 · 5410.1016/j.ejca.2017.12.025 ↗
8. Sempere · Breast Cancer: Targets Ther. · 2015 · 7 · 59
9. Heneghan · J. Oncol. · 2010 · 950201
10. Ouyang · Anal. Chem. · 2019 · 91 · 317910.1021/acs.analchem.8b05909 ↗
11. Janneh · Results Opt. · 2022 · 6 · 10020110.1016/j.rio.2021.100201 ↗
12. Neubrech · Chem. Rev. · 2017 · 117 · 511010.1021/acs.chemrev.6b00743 ↗
13. Aouani · J. Phys. Chem. C · 2013 · 117 · 1862010.1021/jp404535x ↗
14. Rodrigo · Nat. Commun. · 2018 · 9 · 216010.1038/s41467-018-04594-x ↗
15. Dao · Nanoscale · 2019 · 11 · 950810.1039/C9NR00904C ↗
16. Hui · Adv. Sci. · 2021 · 8 · 210058310.1002/advs.202100583 ↗
17. Zhao · Adv. Mater. · 2021 · 210195010.1002/adma.202101950 ↗
18. Yao · Nanoscale · 2021 · 13 · 1013310.1039/D1NR01652K ↗
19. Bian · J. Biophotonics · 2022 · e202200277
20. Dong · Nano Lett. · 2017 · 17 · 576810.1021/acs.nanolett.7b02736 ↗
21. Zhang · Nanophotonics · 2020 · 10 · 25910.1515/nanoph-2020-0373 ↗
22. Zou · Cancers · 2021 · 13 · 213010.3390/cancers13092130 ↗
23. Loke · Cancers · 2019 · 11 · 187210.3390/cancers11121872 ↗
24. Zou · Br. J. Cancer · 2022 · 126 · 47210.1038/s41416-021-01593-6 ↗
25. Wong · J. Biophotonics · 2021 · 14 · e20210015310.1002/jbio.202100153 ↗
26. Maiti · Nano Today · 2012 · 7 · 8510.1016/j.nantod.2012.02.008 ↗
27. U.S · Biosens. Bioelectron. · 2012 · 33 · 29310.1016/j.bios.2011.12.056 ↗
28. F.Geinguenaud , V.Militello and V.Arluison , RNA Spectroscopy Methods and Protocols , 2020 , pp. 119–13310.1007/978-1-0716-0278-2_10 ↗
29. Banyay · Biophys. Chem. · 2003 · 104 · 47710.1016/S0301-4622(03)00035-8 ↗
30. Tsuboi · Appl. Spectrosc. Rev. · 1970 · 3 · 4510.1080/05704927008081687 ↗
31. I.R. Spectrum Table & Chart. Retrieved from: https://www.sigmaaldrich.com/SG/en/technical-documents/technical-article/analytical-chemistry/photometry-and-reflectometry/ir-spectrum-table