A photothermally responsive nanoprobe for bioimaging based on Edman degradation
Source abstract
Abstract
A new type of photothermally responsive nanoprobe based on Edman degradation has been synthesized and characterized. Under irradiation by an 808 nm laser, the heat generated by the gold nanorod core breaks the thiocarbamide structure and releases the fluorescent dye Cy5.5 with increased near-infrared (NIR) fluorescence under mild acidic conditions. This RGD modified nanoprobe is capable of fluorescence imaging of ανβ3 over-expressing U87MG cells in vitro and in vivo. This Edman degradation-based nanoprobe provides a novel strategy to design activatable probes for biomedical imaging and drug/gene delivery.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Gold and Silver Nanoparticles Synthesis and Applications · Nanoplatforms for cancer theranostics · Photoacoustic and Ultrasonic Imaging
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
China-Japan Union Hospital of Jilin University
Changchun, China
Laboratory of Molecular Imaging and Nanomedicine (LOMIN)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Institutes of Health (NIH)
Bethesda, USA
Funding
National Institute of Biomedical Imaging and Bioengineering
References (45)
Show source-provided references
1. Mal · Nature · 2003 · 421 · 35010.1038/nature01362 ↗
2. Liong · J. Mater. Chem. · 2009 · 19 · 625110.1039/b902462j ↗
3. Vivero-Escoto · J. Am. Chem. Soc. · 2009 · 131 · 346210.1021/ja900025f ↗
4. Park · Angew. Chem., Int. Ed. · 2008 · 47 · 295910.1002/anie.200705271 ↗
5. Kulms · Proc. Natl. Acad. Sci. U. S. A. · 1999 · 96 · 797410.1073/pnas.96.14.7974 ↗
6. Meinhardt · J. Biomed. Opt. · 2008 · 13 · 04403010.1117/1.2957970 ↗
7. Frangioni · Curr. Opin. Chem. Biol. · 2003 · 7 · 62610.1016/j.cbpa.2003.08.007 ↗
8. Babin · Angew. Chem., Int. Ed. · 2009 · 48 · 332910.1002/anie.200900255 ↗
9. Lin · J. Am. Chem. Soc. · 2010 · 132 · 1064510.1021/ja103415t ↗
10. Carling · Angew. Chem., Int. Ed. · 2010 · 49 · 378210.1002/anie.201000611 ↗
11. Yan · J. Am. Chem. Soc. · 2011 · 133 · 1971410.1021/ja209793b ↗
12. Jayakumar · Proc. Natl. Acad. Sci. U. S. A. · 2012 · 109 · 848310.1073/pnas.1114551109 ↗
13. Dai · J. Am. Chem. Soc. · 2013 · 135 · 1892010.1021/ja410028q ↗
14. Li · J. Am. Chem. Soc. · 2014 · 136 · 224810.1021/ja412364m ↗
15. Chen · Chem. Rev. · 2014 · 114 · 516110.1021/cr400425h ↗
16. Zhou · Chem. Rev. · 2015 · 115 · 39510.1021/cr400478f ↗
17. Boyer · Nanoscale · 2010 · 2 · 141710.1039/c0nr00253d ↗
18. Xu · Proc. Natl. Acad. Sci. U. S. A. · 1996 · 93 · 1076310.1073/pnas.93.20.10763 ↗
19. Mackey · J. Phys. Chem. B · 2014 · 118 · 131910.1021/jp409298f ↗
20. Yavuz · Nat. Mater. · 2009 · 8 · 93510.1038/nmat2564 ↗
21. Song · ACS Nano · 2015 · 9 · 919910.1021/acsnano.5b03804 ↗
22. Song · ACS Nano · 2013 · 7 · 994710.1021/nn403846v ↗
23. Song · Acc. Chem. Res. · 2015 · 48 · 250610.1021/acs.accounts.5b00059 ↗
24. He · Adv. Mater. · 2015 · 27 · 674110.1002/adma.201502762 ↗
25. Bakhtiari · Angew. Chem., Int. Ed. · 2009 · 48 · 416610.1002/anie.200805303 ↗
26. Zandberg · Nanomed. Nanotechnol. Biol. Med. · 2012 · 8 · 90810.1016/j.nano.2011.10.012 ↗
27. Asadirad · Chem. Commun. · 2013 · 49 · 563910.1039/c3cc42217h ↗
28. Jain · J. Am. Chem. Soc. · 2006 · 128 · 242610.1021/ja056769z ↗
29. Munday · Free Radical Biol. Med. · 1989 · 7 · 65910.1016/0891-5849(89)90147-0 ↗
30. Edman · Arch. Biochem. · 1949 · 22 · 475
31. Lang · Mol. Pharmacol. · 2014 · 11 · 386710.1021/mp400706q ↗
32. Wang · Nat. Mater. · 2014 · 13 · 20410.1038/nmat3819 ↗
33. Ling · Nat. Mater. · 2014 · 13 · 12210.1038/nmat3860 ↗
34. Chen · Mol. Imaging · 2004 · 3 · 9610.1162/1535350041464892 ↗
35. Xie · J. Am. Chem. Soc. · 2008 · 130 · 754210.1021/ja802003h ↗
36. Gao · Acc. Chem. Res. · 2009 · 42 · 109710.1021/ar9000026 ↗
37. Kim · Small · 2011 · 7 · 205210.1002/smll.201100927 ↗
38. Yan · Amino Acids · 2011 · 41 · 43910.1007/s00726-010-0762-5 ↗
39. Liu · J. Mater. Chem. · 2011 · 21 · 717510.1039/c1jm10803d ↗
40. Huang · Biomaterials · 2013 · 34 · 464310.1016/j.biomaterials.2013.02.063 ↗
41. Liu · J. Am. Chem. Soc. · 2013 · 135 · 986910.1021/ja403798m ↗
42. Clegg · Curr. Opin. Biotechnol. · 1995 · 6 · 10310.1016/0958-1669(95)80016-6 ↗
43. Reineck · ACS Nano · 2013 · 7 · 663610.1021/nn401775e ↗
44. Abadeer · ACS Nano · 2014 · 8 · 839210.1021/nn502887j ↗
45. Liu · ACS Nano · 2013 · 7 · 556810.1021/nn401837q ↗