A chloride-doped silver-sulfide cluster [Ag ₁₄₈ S ₂₆ Cl ₃₀ (CCBu ^t ) ₆₀ ] ⁶⁺ : hierarchical assembly, enhanced luminescence and cytotoxicity to cancer cells

The formation of high-nuclear silver(I) clusters remains elusive and their potential applications are still underdeveloped. Herein, we report an unprecedented gigantic Ag₁₄₈ ([Ag₁₄₈S₂₆Cl₃₀(CCBu^t)₆₀](SbF₆)₆) cluster co-templated by Cl^- and S^2-, which was well-defined by single-crystal X-ray diffraction and high-resolution mass spectrometry. The cluster exhibits a hierarchical structure consisting of fused Ag₂₄X₁₆ kernel, Ag₆₀X₂₀ shell and "cluster of clusters assembling" of four pentagonal concave polyhedral {Ag₁₆X₅} units. Furthermore, the silver cluster emits red light at room temperature with a prominent 39.6% QY. The cellular uptake and cytotoxicity indicate that Ag₁₄₈ induces apoptosis of cancer cells in a dose-dependent manner.