A covalently conjugated branched DNA aptamer cluster-based nanoplatform for efficiently targeted drug delivery
Source abstract
Abstract
Targeted delivery of therapeutic drugs is essential for precise treatment of various diseases to reduce possible serious side-effects. A screened DNA aptamer has been widely developed for active targeting delivery. Herein, we report a facile strategy for the construction of a branched DNA aptamer cluster-based nanoplatform for efficiently targeted drug delivery. In our design, the terminal-modified DNA aptamer can be covalently conjugated to form a branched aptamer cluster by click reaction easily. The branched aptamer cluster-modified DNA tetrahedron (TET) demonstrates highly targeted cellular uptake with the modification of only one site. After loading the chemotherapeutic drug (doxorubicin, DOX), the DNA aptamer cluster-based nanoplatform elicits a remarkable and selective inhibition of tumor cell proliferation by much-enhanced targeted delivery. This covalently conjugated branched DNA aptamer cluster-based nanoplatform provides a new strategy for the development of targeted drug delivery.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Advanced biosensing and bioanalysis techniques · RNA Interference and Gene Delivery · DNA and Nucleic Acid Chemistry
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Dongdan Santiao No. 5, Beijing 100005, China
CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, National Center for NanoScience and Technology, 11 BeiYiTiao, ZhongGuanCun, Beijing 100190, China
University of Chinese Academy of Sciences, Beijing 100049, China
School of Life Sciences, Shanghai University, Shanghai 200444, China
Funding
National Key Research and Development Program of China · Chinese Academy of Sciences · Youth Innovation Promotion Association of the Chinese Academy of Sciences · National Natural Science Foundation of China · K. C. Wong Education Foundation
References (69)
Show source-provided references
1. Scott · Nat. Rev. Cancer · 2012 · 12 · 27810.1038/nrc3236 ↗
2. Sahin · Nat. Rev. Drug Discovery · 2014 · 13 · 75910.1038/nrd4278 ↗
3. Cox · Nat. Med. · 2015 · 21 · 12110.1038/nm.3793 ↗
4. Schneider · Nat. Rev. Drug Discovery · 2021 · 20 · 78910.1038/s41573-021-00245-x ↗
5. Dhar · Proc. Natl. Acad. Sci. U. S. A. · 2008 · 105 · 1735610.1073/pnas.0809154105 ↗
6. Wu · Proc. Natl. Acad. Sci. U. S. A. · 2010 · 107 · 510.1073/pnas.0909611107 ↗
7. Liu · Small · 2011 · 7 · 167310.1002/smll.201002292 ↗
8. Yuan · Angew. Chem., Int. Ed. · 2013 · 52 · 1396510.1002/anie.201305707 ↗
9. Tang · ACS Nano · 2015 · 9 · 507210.1021/acsnano.5b00166 ↗
10. Li · ACS Appl. Mater. Interfaces · 2016 · 8 · 2573310.1021/acsami.6b08210 ↗
11. Li · Angew. Chem., Int. Ed. · 2018 · 57 · 1158910.1002/anie.201804682 ↗
12. Yang · Angew. Chem., Int. Ed. · 2018 · 57 · 1704810.1002/anie.201809753 ↗
13. Song · Angew. Chem., Int. Ed. · 2019 · 58 · 223610.1002/anie.201809337 ↗
14. Ge · J. Am. Chem. Soc. · 2020 · 142 · 880010.1021/jacs.0c01580 ↗
15. Fang · Acc. Chem. Res. · 2010 · 43 · 4810.1021/ar900101s ↗
16. Pang · Cancers · 2018 · 10 · 4710.3390/cancers10020047 ↗
17. Keefe · Nat. Rev. Drug Discovery · 2010 · 9 · 53710.1038/nrd3141 ↗
18. Tan · Chem. Rev. · 2013 · 113 · 284210.1021/cr300468w ↗
19. Krissanaprasit · Chem. Rev. · 2021 · 121 · 1379710.1021/acs.chemrev.0c01332 ↗
20. Lin · ACS Appl. Mater. Interfaces · 2021 · 13 · 936910.1021/acsami.0c15644 ↗
21. Wu · Chem. Rev. · 2021 · 121 · 1203510.1021/acs.chemrev.0c01140 ↗
22. Xie · ACS Appl. Mater. Interfaces · 2021 · 13 · 954210.1021/acsami.0c19562 ↗
23. Kuai · J. Am. Chem. Soc. · 2017 · 139 · 912810.1021/jacs.7b04547 ↗
24. Zhou · Nat. Rev. Drug Discovery · 2017 · 16 · 18110.1038/nrd.2016.199 ↗
25. Jiang · J. Am. Chem. Soc. · 2018 · 140 · 678010.1021/jacs.8b03442 ↗
26. Bhatia · Angew. Chem., Int. Ed. · 2009 · 48 · 413410.1002/anie.200806000 ↗
27. Cheng · Angew. Chem., Int. Ed. · 2009 · 48 · 766010.1002/anie.200902538 ↗
28. Wu · J. Am. Chem. Soc. · 2013 · 135 · 1864410.1021/ja4094617 ↗
29. Brunner · Angew. Chem., Int. Ed. · 2015 · 54 · 194610.1002/anie.201409803 ↗
30. Hong · Angew. Chem., Int. Ed. · 2015 · 54 · 674010.1002/anie.201412493 ↗
31. Li · J. Am. Chem. Soc. · 2015 · 137 · 141210.1021/ja512293f ↗
32. Veetil · Nat. Nanotechnol. · 2017 · 12 · 118310.1038/nnano.2017.159 ↗
33. Cheng · Chem. Commun. · 2018 · 54 · 968710.1039/C8CC05066J ↗
34. Kashida · Angew. Chem., Int. Ed. · 2020 · 59 · 1136010.1002/anie.202004221 ↗
35. Kwon · Nat. Chem. · 2020 · 12 · 2610.1038/s41557-019-0369-8 ↗
36. Li · Nat. Mater. · 2004 · 3 · 3810.1038/nmat1045 ↗
37. Wang · J. Am. Chem. Soc. · 2007 · 129 · 816910.1021/ja0693441 ↗
38. He · Nature · 2008 · 452 · 19810.1038/nature06597 ↗
39. Zhang · Nat. Nanotechnol. · 2015 · 10 · 77910.1038/nnano.2015.162 ↗
40. Dong · Chem. Rev. · 2020 · 120 · 942010.1021/acs.chemrev.0c00294 ↗
41. Scheffler · Angew. Chem., Int. Ed. · 1999 · 38 · 331110.1002/(SICI)1521-3773(19991115)38:22<3311::AID-ANIE3311>3.0.CO;2-2 ↗
42. Aldaye · J. Am. Chem. Soc. · 2007 · 129 · 1007010.1021/ja073305n ↗
43. Keller · J. Am. Chem. Soc. · 2008 · 130 · 1318810.1021/ja8045348 ↗
44. Zimmermann · Angew. Chem., Int. Ed. · 2008 · 47 · 362610.1002/anie.200702682 ↗
45. Lee · ACS Nano · 2011 · 5 · 206710.1021/nn1032455 ↗
46. Paredes · ACS Nano · 2013 · 7 · 395310.1021/nn305787m ↗
47. Hong · J. Am. Chem. Soc. · 2015 · 137 · 818410.1021/jacs.5b03485 ↗
48. Cheng · J. Am. Chem. Soc. · 2021 · 143 · 175210.1021/jacs.0c11843 ↗
49. Distler · J. Am. Chem. Soc. · 2021 · 143 · 1351310.1021/jacs.1c07240 ↗
50. Hong · J. Am. Chem. Soc. · 2011 · 133 · 1391410.1021/ja2056984 ↗
51. Ding · Angew. Chem., Int. Ed. · 2018 · 57 · 306410.1002/anie.201711242 ↗
52. Liu · J. Am. Chem. Soc. · 2019 · 141 · 1903210.1021/jacs.9b09043 ↗
53. Liu · Angew. Chem., Int. Ed. · 2021 · 60 · 185310.1002/anie.202011174 ↗
54. Jiang · J. Am. Chem. Soc. · 2012 · 134 · 1339610.1021/ja304263n ↗
55. Zhao · ACS Nano · 2012 · 6 · 868410.1021/nn3022662 ↗
56. Song · Nanoscale · 2017 · 9 · 775010.1039/C7NR02222K ↗
57. Ijas · Nucleic Acids Res. · 2021 · 49 · 304810.1093/nar/gkab097 ↗
58. Ferreira · Tumor Biol. · 2006 · 27 · 28910.1159/000096085 ↗
59. Kufe · Nat. Rev. Cancer · 2009 · 9 · 87410.1038/nrc2761 ↗
60. Jani · Nat. Chem. Biol. · 2020 · 16 · 66010.1038/s41589-020-0491-3 ↗
61. Ferreira · Nucleic Acids Res. · 2009 · 37 · 86610.1093/nar/gkn967 ↗
62. Li · J. Am. Chem. Soc. · 2021 · 143 · 1989310.1021/jacs.1c09472 ↗
63. Goodman · Science · 2005 · 310 · 166110.1126/science.1120367 ↗
64. Lee · Nat. Nanotechnol. · 2012 · 7 · 38910.1038/nnano.2012.73 ↗
65. Kim · Chem. Sci. · 2014 · 5 · 153310.1039/C3SC52601A ↗
66. Hu · Chem. Rev. · 2019 · 119 · 645910.1021/acs.chemrev.7b00663 ↗
67. Li · J. Am. Chem. Soc. · 2019 · 141 · 1891010.1021/jacs.9b11015 ↗
68. Yin · Angew. Chem., Int. Ed. · 2020 · 59 · 1040610.1002/anie.202002020 ↗
69. Cai · ACS Nano · 2021 · 15 · 1915010.1021/acsnano.1c07307 ↗