Design and assembly of supramolecular dual-modality nanoprobes
Source abstract
Abstract
We report the design and synthesis of self-assembling dual-modality molecular probes containing both a fluorophore for optical imaging and a metal ion chelator for imaging with MRI or radionuclide methods. These molecular probes can spontaneously associate into spherical nanoparticles under physiological conditions. We demonstrate the use of these supramolecular nanoprobes for live-cell optical imaging, as well as their potential use as MRI contrast agents after complexation with gadolinium. Our results suggest that self-assembly into supramolecular nanoprobes presents an effective means to enhance and tune the relaxivities of molecular probes.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Supramolecular Self-Assembly in Materials · Supramolecular Chemistry and Complexes · Advanced biosensing and bioanalysis techniques
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Chemical and Biomolecular Engineering
Johns Hopkins University
Baltimore, USA
The Russell H. Morgan Department of Radiology and Radiological Science
F.M. Kirby Research Center for Functional Brain Imaging
Kennedy Krieger Institute
Department of Oncology and Sidney Kimmel Comprehensive Cancer Center
Johns Hopkins University School of Medicine
Funding
Division of Materials Research
References (49)
Show source-provided references
1. Aida · Science · 2012 · 335 · 81310.1126/science.1205962 ↗
2. Gadt · Nat. Mater. · 2009 · 8 · 14410.1038/nmat2356 ↗
3. Bates · Science · 2012 · 336 · 43410.1126/science.1215368 ↗
4. Cui · Science · 2007 · 317 · 64710.1126/science.1141768 ↗
5. Kuang · Angew. Chem., Int. Ed. · 2014 · 53 · 810410.1002/anie.201402216 ↗
6. Lin · Curr. Opin. Chem. Eng. · 2015 · 7 · 7510.1016/j.coche.2014.11.005 ↗
7. Ramakers · Chem. Soc. Rev. · 2014 · 43 · 274310.1039/c3cs60362h ↗
8. Trent · Soft Matter · 2011 · 7 · 957210.1039/c1sm05862b ↗
9. Cui · Biopolymers · 2010 · 94 · 110.1002/bip.21328 ↗
10. Sathaye · Biomacromolecules · 2014 · 15 · 389110.1021/bm500874t ↗
11. Kumar · ACS Nano · 2015 · 9 · 86010.1021/nn506544b ↗
12. Pires · J. Am. Chem. Soc. · 2015 · 137 · 57610.1021/ja5111893 ↗
13. Kelly · Curr. Opin. Struct. Biol. · 1998 · 8 · 10110.1016/S0959-440X(98)80016-X ↗
14. Rothemund · Nature · 2006 · 440 · 29710.1038/nature04586 ↗
15. Pearce · Soft Matter · 2015 · 11 · 10910.1039/C4SM01332H ↗
16. Bae · Angew. Chem., Int. Ed. · 2003 · 42 · 464010.1002/anie.200250653 ↗
17. Haag · Angew. Chem., Int. Ed. · 2004 · 43 · 27810.1002/anie.200301694 ↗
18. Preslar · ACS Nano · 2014 · 8 · 732510.1021/nn502393u ↗
19. Hu · Nat. Nanotechnol. · 2013 · 8 · 93310.1038/nnano.2013.254 ↗
20. Cai · Small · 2007 · 3 · 184010.1002/smll.200700351 ↗
21. Schipper · Small · 2009 · 5 · 12610.1002/smll.200800003 ↗
22. Chapman · Nano Today · 2013 · 8 · 45410.1016/j.nantod.2013.06.001 ↗
23. Zhang · Curr. Opin. Biotechnol. · 2015 · 34C · 17110.1016/j.copbio.2015.01.009 ↗
24. Hu · Nanoscale · 2014 · 6 · 6510.1039/C3NR05444F ↗
25. Wang · Annu. Rev. Med. · 2012 · 63 · 18510.1146/annurev-med-040210-162544 ↗
26. Gao · Nano Today · 2009 · 4 · 3710.1016/j.nantod.2008.10.009 ↗
27. Chien · Chem. Commun. · 2011 · 47 · 16710.1039/C0CC02291H ↗
28. Dawidczyk · J. Controlled Release · 2014 · 187 · 13310.1016/j.jconrel.2014.05.036 ↗
29. Xie · Adv. Drug Delivery Rev. · 2010 · 62 · 106410.1016/j.addr.2010.07.009 ↗
30. Jennings · Chem. Commun. · 2009 · 351110.1039/b821903f ↗
31. Lee · Mol. Imaging · 2009 · 8 · 8710.2310/7290.2009.00013 ↗
32. Brindle · Nat. Rev. Cancer · 2008 · 8 · 9410.1038/nrc2289 ↗
33. Banerjee · Angew. Chem., Int. Ed. · 2011 · 50 · 916710.1002/anie.201102872 ↗
34. Olson · Proc. Natl. Acad. Sci. U. S. A. · 2010 · 107 · 431110.1073/pnas.0910283107 ↗
35. Whitney · Nat. Biotechnol. · 2011 · 1
36. Desreux · Inorg. Chem. · 1980 · 19 · 131910.1021/ic50207a042 ↗
37. Meyer · Invest. Radiol. · 1988 · 23 · S23210.1097/00004424-198809001-00048 ↗
38. J. N. Israelachvili , Intermolecular and Surface Forces, Academic Press, 2011
39. Futaki · Bioconjugate Chem. · 2001 · 12 · 100510.1021/bc015508l ↗
40. Khalil · Gene Ther. · 2004 · 11 · 63610.1038/sj.gt.3302128 ↗
41. Chen · J. Controlled Release · 2014 · 191 · 12310.1016/j.jconrel.2014.05.051 ↗
42. Zhang · Mol. Pharm. · 2014 · 11 · 96410.1021/mp400619v ↗
43. Vichai · Nat. Protocols · 2006 · 1 · 111210.1038/nprot.2006.179 ↗
44. Caravan · Chem. Rev. · 1999 · 99 · 229310.1021/cr980440x ↗
45. Nicolle · J. Biol. Inorg. Chem. · 2002 · 7 · 75710.1007/s00775-002-0353-3 ↗
46. Bull · Nano Lett. · 2005 · 5 · 110.1021/nl0484898 ↗
47. Caravan · Contrast Media Mol. Imaging · 2009 · 4 · 8910.1002/cmmi.267 ↗
48. Ghosh · J. Am. Chem. Soc. · 2012 · 134 · 364710.1021/ja211113n ↗
49. Matsumura · Cancer Res. · 1986 · 46 · 6387