journal article·2020

Non-reversible heat-induced gelation of a biocompatible Fmoc-hexapeptide in water

Jonathan P. Wojciechowski, Adam D. Martin, Eric Y. Du, Christopher J. Garvey, Robert E. Nordon, Pall Thordarson

Nanoscale· Volume 12· Issue 15
Publisher page

Abstract

Hydrogel materials which respond to changes in temperature are widely applicable for injectable drug delivery or tissue engineering applications. Here, we report the unsual heat-induced gelation behaviour of a low molecular weight gelator based on an Fmoc-hexapeptide, Fmoc-GFFRGD. We show that Fmoc-GFFRGD forms kinetically stable fibres when mixed with divalent cations (e.g. Ca2+). Gelation of the mixture occurs upon heating of the mixture which enables electrostatic screening by the divalent cations and hydrophobic collapse of the fibres to give a self-supporting hydrogel network that shows good biocompatibility with L929 fibroblast cells. This work highlights a unique mechanism to initiate heat-induced gelation which should find opportunities as a gelation trigger for injectable hydrogels or fundamental self-assembly applications.
Source: europepmc · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Supramolecular Self-Assembly in Materials · Chemical Synthesis and Analysis · Glycosylation and Glycoproteins Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Chemistry

The Australian Centre for Nanomedicine and the ARC Centre for Convergent Bio-Nano Science & Technology

University of New South Wales

Sydney

Australia

Dementia Research Centre

Department of Biomedical Science

Faculty of Medicine and Health Sciences

Macquarie University

Australian Nuclear Science and Technology Organisation

Lucas Heights

Asutralia

Lund Institute for Advanced Neutron and X-ray Scattering

Lund

Graduate School of Biomedical Engineering

University of New South Wales Sydney

Funding

Australian Research Council · Australian Nuclear Science and Technology Organisation · National Health and Medical Research Council

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