Deciphering the role of substrate stiffness in enhancing the internalization efficiency of plasmid DNA in stem cells using lipid-based nanocarriers
Source abstract
Abstract
This study investigates the role of substrate stiffness in the non-viral transfection of human adipose-derived stem cells (hASCs) with the aim to maximize the hASC expression of vascular endothelial growth factor (VEGF). The results confirm the direct effect of substrate stiffness in regulating cytoskeletal remodeling and corresponding plasmid internalization.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: RNA Interference and Gene Delivery · Lipid Membrane Structure and Behavior · Nanoparticle-Based Drug Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
BioIntel Research Laboratory
Department of Chemical and Petroleum Engineering
Bioengineering Graduate Program
School of Engineering
University of Kansas
Funding
National Institute of General Medical Sciences
References (36)
Show source-provided references
1. Rodrigues · Stem Cell Res. Ther. · 2010 · 1 · 3210.1186/scrt32 ↗
2. Pacelli · Acta Biomater. · 2017 · 58 · 47910.1016/j.actbio.2017.05.026 ↗
3. Pacelli · Adv. Drug Delivery Rev. · 2017 · 120 · 5010.1016/j.addr.2017.07.011 ↗
4. Chen · PLoS One · 2013 · 8 · e7367310.1371/journal.pone.0073673 ↗
5. Zhou · J. Tissue Eng. Regener. Med. · 2017 · 12 · e56610.1002/term.2327 ↗
6. Van Pham · Biomed. Res. Ther. · 2016 · 3 · 476
7. Waters · Nanoscale · 2016 · 8 · 737110.1039/C5NR07806G ↗
8. Petrenko · Stem Cell Res. Ther. · 2017 · 8 · 9410.1186/s13287-017-0558-6 ↗
9. Dall'Era · Int. J. Impotence Res. · 2008 · 20 · 30710.1038/ijir.2008.1 ↗
10. Schönmeyr · Tissue Eng., Part A · 2010 · 16 · 65310.1089/ten.tea.2009.0426 ↗
11. Nikol · Cardiovasc. Res. · 2007 · 73 · 44310.1016/j.cardiores.2006.12.005 ↗
12. Seow · Mol. Ther. · 2009 · 17 · 76710.1038/mt.2009.41 ↗
13. Medina-Kauwe · Gene Ther. · 2005 · 12 · 173410.1038/sj.gt.3302592 ↗
14. Ramamoorth · J. Clin. Diagn. Res. · 2015 · 9 · GE01
15. Adler · Nano Today · 2010 · 5 · 55310.1016/j.nantod.2010.10.007 ↗
16. Missirlis · PLoS One · 2014 · 9 · e9654810.1371/journal.pone.0096548 ↗
17. Echarri · J. Cell Sci. · 2015 · 128 · 274710.1242/jcs.153940 ↗
18. Yao · J. Neurosci. · 2013 · 33 · 1579310.1523/JNEUROSCI.2171-13.2013 ↗
19. McMahon · Nat. Rev. Mol. Cell Biol. · 2011 · 12 · 51710.1038/nrm3151 ↗
20. Smythe · J. Cell Sci. · 2006 · 119 · 458910.1242/jcs.03247 ↗
21. Kong · Nat. Mater. · 2005 · 4 · 46010.1038/nmat1392 ↗
22. Vertelov · Sci. Rep. · 2016 · 6 · 3341110.1038/srep33411 ↗
23. Pacelli · Sci. Rep. · 2017 · 7 · 657710.1038/s41598-017-06028-y ↗
24. Prager-Khoutorsky · Nat. Cell Biol. · 2011 · 13 · 145710.1038/ncb2370 ↗
25. Ehrlicher · Proc. Natl. Acad. Sci. U. S. A. · 2015 · 112 · 661910.1073/pnas.1505652112 ↗
26. Butler · Am. J. Physiol.: Cell Physiol. · 2002 · 282 · C59510.1152/ajpcell.00270.2001 ↗
27. Chi · Int. J. Mol. Sci. · 2013 · 14 · 708910.3390/ijms14047089 ↗
28. Son · Biochim. Biophys. Acta, Biomembr. · 2000 · 1466 · 1110.1016/S0005-2736(00)00176-0 ↗
29. Carapuca · Mol. Biotechnol. · 2007 · 37 · 12010.1007/s12033-007-0007-3 ↗
30. Chu · Acta Biomater. · 2012 · 8 · 261210.1016/j.actbio.2012.04.014 ↗
31. Cui · Biotechnol. Lett. · 2014 · 36 · 110.1007/s10529-013-1325-0 ↗
32. Cardarelli · Sci. Rep. · 2016 · 6 · 2587910.1038/srep25879 ↗
33. Parton · Nat. Rev. Mol. Cell Biol. · 2013 · 14 · 9810.1038/nrm3512 ↗
34. Rejman · Biochem. J. · 2004 · 377 · 15910.1042/bj20031253 ↗
35. Yarak · An. Bras. Dermatol. · 2010 · 85 · 64710.1590/S0365-05962010000500008 ↗
36. Paul · ACS Nano · 2014 · 8 · 805010.1021/nn5020787 ↗