A helix foldamer oligopeptide improves intracellular stability and prolongs protein expression of the delivered mRNA
Source abstract
Abstract
Prolonging the duration of protein expression from mRNA is a major challenge in the development of mRNA nanomedicines. mRNA complexed with helix foldamer oligopeptides consisting of arginine and α-aminoisobutyric acids showed higher intracellular stability than that complexed with oligoarginines, thereby maintaining efficient protein translation for three days.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: RNA Interference and Gene Delivery · RNA and protein synthesis mechanisms · Advanced biosensing and bioanalysis techniques
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Medical Chemistry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
Innovation Center of NanoMedicine (iCONM), Kawasaki Institute of Industrial Promotion, Kawasaki, Japan
Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
Funding
Ministry of Education, Culture, Sports, Science and Technology · Japan Agency for Medical Research and Development
References (34)
Show source-provided references
1. Verbeke · J. Controlled Release · 2021 · 333 · 51110.1016/j.jconrel.2021.03.043 ↗
2. Hajj · Nat. Rev. Mater. · 2017 · 2 · 1705610.1038/natrevmats.2017.56 ↗
3. Zhong · Nano Today · 2018 · 23 · 1610.1016/j.nantod.2018.10.005 ↗
4. Uchida · Mol. Pharm. · 2020 · 17 · 365410.1021/acs.molpharmaceut.0c00618 ↗
5. Truong · Proc. Natl. Acad. Sci. U. S. A. · 2019 · 116 · 2115010.1073/pnas.1906182116 ↗
6. Martini · Hum. Gene Ther. · 2019 · 30 · 118010.1089/hum.2019.090 ↗
7. Cirelli · Cell · 2019 · 177 · 115310.1016/j.cell.2019.04.012 ↗
8. Schwanhausser · Nature · 2011 · 473 · 33710.1038/nature10098 ↗
9. Anderson · Nucleic Acids Res. · 2011 · 39 · 932910.1093/nar/gkr586 ↗
10. Nogimori · Nucleic Acids Res. · 2019 · 47 · 43210.1093/nar/gky1087 ↗
11. Zhang · Adv. Biosyst. · 2020 · 4 · e200005710.1002/adbi.202000057 ↗
12. Uchida · J. Am. Chem. Soc. · 2016 · 138 · 147810.1021/jacs.5b11726 ↗
13. Sabnis · Mol. Ther. · 2018 · 26 · 150910.1016/j.ymthe.2018.03.010 ↗
14. Koji · Biomaterials · 2020 · 261 · 12033210.1016/j.biomaterials.2020.120332 ↗
15. Cheng · Nat. Nanotechnol. · 2020 · 15 · 31310.1038/s41565-020-0669-6 ↗
16. Tanaka · Adv. Funct. Mater. · 2020 · 30 · 191057510.1002/adfm.201910575 ↗
17. Uchida · J. Am. Chem. Soc. · 2014 · 136 · 1239610.1021/ja506194z ↗
18. Dirisala · J. Drug Targeting · 2019 · 27 · 67010.1080/1061186X.2018.1550646 ↗
19. Nakase · Adv. Drug Delivery Rev. · 2008 · 60 · 59810.1016/j.addr.2007.10.006 ↗
20. Miyazaki · Eur. Polym. J. · 2020 · 140 · 11002810.1016/j.eurpolymj.2020.110028 ↗
21. Crisma · Pept. Sci. · 2015 · 104 · 4610.1002/bip.22581 ↗
22. Le Bailly · Chem. Commun. · 2016 · 52 · 485210.1039/C6CC00788K ↗
23. Akagawa · Eur. J. Org. Chem. · 2018 · 2018 · 527810.1002/ejoc.201800774 ↗
24. Oba · ACS Biomater. Sci. Eng. · 2019 · 5 · 566010.1021/acsbiomaterials.8b01451 ↗
25. Oba · Sci. Rep. · 2019 · 9 · 134910.1038/s41598-018-38063-8 ↗
26. Oba · Bioorg. Med. Chem. · 2015 · 23 · 491110.1016/j.bmc.2015.05.025 ↗
27. Moghimi · Mol. Ther. · 2005 · 11 · 99010.1016/j.ymthe.2005.02.010 ↗
28. Leclerc · BioTechniques · 2000 · 29 · 59010.2144/00293rr02 ↗
29. Gilon · EMBO J. · 1998 · 17 · 275910.1093/emboj/17.10.2759 ↗
30. Robertson · Proc. Natl. Acad. Sci. U. S. A. · 2008 · 105 · 1798810.1073/pnas.0809482105 ↗
31. Cheng · Curr. Chem. Genomics · 2010 · 4 · 8410.2174/1875397301004010084 ↗
32. Ogris · Gene Ther. · 1999 · 6 · 59510.1038/sj.gt.3300900 ↗
33. Kurimoto · Molecules · 2019 · 24 · 130310.3390/molecules24071303 ↗
34. Uchida · J. Biomed. Mater. Res., Part A · 2019 · 107 · 97810.1002/jbm.a.36614 ↗