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journal article·2018Open access

Highly specific targeting of human acute myeloid leukaemia cells using pharmacologically active nanoconjugates

Inna M. Yasinska, Giacomo Ceccone, Isaac Ojea-Jimenez, Jessica Ponti, Rohanah Hussain, Giuliano Siligardi, Steffen M. Berger, Elizaveta Fasler-Kan, Marco Bardelli, Luca Varani, Walter Fiedler, Jasmin Wellbrock, Ulrike Raap, Bernhard F. Gibbs, Luigi Calzolai, Vadim V. Sumbayev

Nanoscale· Volume 10· Issue 13
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Source abstract

Abstract

In this study we used 5 nm gold nanoparticles as delivery platforms to target cancer cells expressing the immune receptor Tim-3 using single chain antibodies. Gold surfaces were also covered with the cytotoxic drug rapamycin which was immobilised using a glutathione linker. These nanoconjugates allowed highly specific and efficient delivery of cytotoxic rapamycin into human malignant blood cells.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗

Research context

Nanomaterials

OpenAlex topics: Galectins and Cancer Biology · Phagocytosis and Immune Regulation · Toxin Mechanisms and Immunotoxins

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Pharmacy

University of Kent

Kent

UK

European Commission Joint Research Centre

Ispra

Italy

Beamline B23

Diamond Light Source

Didcot

Department of Paediatric Surgery and Department of Biomedical Research

Children's Hospital

Inselspital

University of Bern

3010 Bern

Institute for Research in Biomedicine

Universita’ della Svizzera italiana (USI)

6500 Bellinzona

Switzerland

Department of Oncology

Hematology and Bone Marrow Transplantation with Section Pneumology

Hubertus Wald University Cancer Center

University Medical Center Hamburg-Eppendorf

Germany

Department of Dermatology

References (20)

Show source-provided references
1. Vick · Expert Opin. Invest. Drugs · 2016 · 25 · 110.1080/13543784.2016.1175433 ↗
2. Romero · Sci. Transl. Med. · 2016 · 8 · 334 ps910.1126/scitranslmed.aaf0685 ↗
3. Sumbayev · Small · 2013 · 9 · 47210.1002/smll.201201528 ↗
4. Gibbs · J. Biomed. Nanotechnol. · 2014 · 10 · 125910.1166/jbn.2014.1807 ↗
5. Pascual Garcia · Sci. Rep. · 2013 · 3 · 132610.1038/srep01326 ↗
6. Gonçalves Silva · OncoImmunology · 2016 · 5 · e119553510.1080/2162402X.2016.1195535 ↗
7. Kikushige · Int. J. Hematol. · 2013 · 98 · 62710.1007/s12185-013-1433-6 ↗
8. Goncalves Silva · Oncotarget · 2015 · 6 · 3382310.18632/oncotarget.5257 ↗
9. Prokhorov · Int. J. Biochem. Cell Biol. · 2015 · 59 · 1110.1016/j.biocel.2014.11.017 ↗
10. Coradeghini · Toxicol. Lett. · 2013 · 217 · 20510.1016/j.toxlet.2012.11.022 ↗
11. Pabst · Nat. Methods · 2014 · 11 · 43610.1038/nmeth.2847 ↗
12. Fasler-Kan · Int. J. Interferon, Cytokine Mediator Res. · 2010 · 2 · 12710.2147/IJICMR.S13642 ↗
13. Hussain · J. Synchrotron Radiat. · 2012 · 19 · 13210.1107/S0909049511038982 ↗
14. Hussain · Compr. Chirality · 2012 · 8 · 43810.1016/B978-0-08-095167-6.00841-7 ↗
15. Hussain · J. Synchrotron Radiat. · 2015 · 22 · 86210.1107/S1600577515007602 ↗
16. Midsonai · Proc. Natl. Acad. Sci. U. S. A. · 2015 · 112 · E309510.1073/pnas.1500851112 ↗
17. Tietze · Anal. Biochem. · 1969 · 27 · 50210.1016/0003-2697(69)90064-5 ↗
18. Calzolai · J. Chromatogr. A · 2011 · 1218 · 423410.1016/j.chroma.2011.01.017 ↗
19. Setyawati · Small · 2016 · 12 · 560110.1002/smll.201601669 ↗
20. Gonçalves Silva · EBioMedicine · 2017 · 22 · 4410.1016/j.ebiom.2017.07.018 ↗