journal article·2021

Catalytic and photoresponsive BiZ/Cu x S heterojunctions with surface vacancies for the treatment of multidrug-resistant clinical biofilm-associated infections

Amit Nain, Hao-Hsin Huang, Daniel M. Chevrier, Yu-Ting Tseng, Arumugam Sangili, Yu-Feng Lin, Yu-Fen Huang, Lung Chang, Fu-Chieh Chang, Chih-Ching Huang, Fan-Gang Tseng, Huan-Tsung Chang

Nanoscale· Volume 13· Issue 44
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Abstract

We report a one-pot facile synthesis of highly photoresponsive bovine serum albumin (BSA) templated bismuth-copper sulfide nanocomposites (BSA-BiZ/CuxS NCs, where BiZ represents in situ formed Bi2S3 and bismuth oxysulfides (BOS)). As-formed surface vacancies and BiZ/CuxS heterojunctions impart superior catalytic, photodynamic and photothermal properties. Upon near-infrared (NIR) irradiation, the BSA-BiZ/CuxS NCs exhibit broad-spectrum antibacterial activity, not only against standard multidrug-resistant (MDR) bacterial strains but also against clinically isolated MDR bacteria and their associated biofilms. The minimum inhibitory concentration of BSA-BiZ/CuxS NCs is 14-fold lower than that of BSA-CuxS NCs because their multiple heterojunctions and vacancies facilitated an amplified phototherapeutic response. As-prepared BSA-BiZ/CuxS NCs exhibited substantial biofilm inhibition (90%) and eradication (>75%) efficiency under NIR irradiation. Furthermore, MRSA-infected diabetic mice were immensely treated with BSA-BiZ/CuxS NCs coupled with NIR irradiation by destroying the mature biofilm on the wound site, which accelerated the wound healing process via collagen synthesis and epithelialization. We demonstrate that BSA-BiZ/CuxS NCs with superior antimicrobial activity and high biocompatibility hold great potential as an effective photosensitive agent for the treatment of biofilm-associated infections.
Source: europepmc · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced Photocatalysis Techniques · Dental Anxiety and Anesthesia Techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Physics, Academia Sinica, Taipei 11529, Taiwan

Nano Science and Technology Program, Taiwan International Graduate Program, Taipei 11529, Taiwan

Department of Engineering and System Science, National Tsing Hua University, Hsinchu 30013, Taiwan

Department of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung 20224, Taiwan

Biosciences and Biotechnologies Institute of Aix-Marseille (BIAM), CEA Cadarache, Bâtiment 1900, Saint-Paul-lez-Durance, France

Department of Chemistry, National Taiwan University, Taipei 10617, Taiwan

Institute of Analytical and Environmental Sciences, National Tsing Hua University, Hsinchu 30013, Taiwan

Department of Pediatrics, Mackay Memorial Hospital and Mackay Junior College of Medicine, Taipei, 10449, Taiwan

Infection Control Centre, Mackay Memorial Hospital, Taipei, 10449, Taiwan

College of Management, Yuan Ze University, Taoyuan City, 32003, Taiwan

Nursing and Management, Mackay Junior College of Medicine, Taipei, 10650, Taiwan

Centre of Excellence for the Oceans, National Taiwan Ocean University, Keelung 20224, Taiwan

Research Centre for Applied Sciences Academia Sinica, Taipei 11529, Taiwan

Frontier Research Centre on Fundamental and Applied Sciences of Matters, National Tsing Hua University, Hsinchu 30013, Taiwan

Funding

Ministry of Science and Technology, Taiwan

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