Topology-Dependent Antifreeze Properties of Biomimetic Linear and Star-Shaped Peptoids
Source abstract
Abstract
Developing safe and efficient cryoprotectants is critical for effective cryopreservation in biomedical applications. Inspired by natural antifreeze proteins (AFPs), a series of linear and star-shaped peptoids featuring isopropanol side chains to mimic the amphiphilic characteristics of threonine were prepared. The effects of chain length and molecular topology on antifreeze properties were systematically investigated. Both ice recrystallization inhibition (IRI) and ice crystal growth suppression improved with increasing chain length, and star-shaped peptoids exhibited superior performance. Notably, the star-shaped peptoid S-(A6)3 demonstrated excellent antifreeze activity and low cytotoxicity, highlighting its promise as a novel, non-toxic alternative to conventional cryoprotectants like DMSO. These findings provide valuable insight into the structure-property relationship of peptoids for cryopreservation applications.
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Research context
OpenAlex topics: Insect and Arachnid Ecology and Behavior · nanoparticles nucleation surface interactions · Physiological and biochemical adaptations
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Affiliations
School of Materials Sciences and Engineering, Jiangsu University, Zhenjiang 212013, China
College of Materials Science and Engineering, Nanjing Forestry University, Nanjing 210037, China
Department of Chemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
Funding
National Natural Science Foundation of China · King Saud University, Riyadh, Saudi Arabia
References (30)
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