Detection of cimetidine in human plasma by surface‐enhanced Raman scattering
Source abstract
Abstract
This study describes a sensitive and rapid method for the quantification of Cimetidine (Cim) based on surface‐enhanced Raman scattering (SERS), using silver nanoparticles as an SERS substrate. Ag nanoparticle was fabricated by hydrothermal method. The experiment includes the selection of solvent types and optimisation of volume radio. Results suggested that the intensity and logarithmic Cim concentration in the range from 1.0 × 10 −8 to 1.0 × 10 −4 M has a linear relationship with the coefficient of determination ( R 2 ) of 0.989, the limit of detection (LOD) of 2.9 × 10 −9 M, by targeting the characteristic peak at 2150 cm −1 . The LOD of Cim in plasma using this method was as low as 1 ng/ml. This indicates that the method has a potential for detection of Cim in biological samples.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Veterinary Pharmacology and Anesthesia · Antibiotics Pharmacokinetics and Efficacy · Pharmacological Effects and Assays
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
College of Chemistry and Chemical Engineering Central South University Changsha 410083 People's Republic of China
Funding
National Natural Science Foundation of China
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