Facile preparation of cancer cell membrane vehicle loaded with indocyanine green for effective photothermal therapy of cancer

In this study, using the lung cancer cells (A549) as the model cell line, the authors proposed a facile method to prepare uniform‐sized cancer cell membrane (Ccm) vehicle, which was then employed to load the photothermal agent indocyanine green (ICG) for effective cancer photothermal therapy (PTT). The as‐prepared Ccm/ICG was demonstrated to have a uniform particle size of around 100 nm, which was capable of targeting the A549 cells through Ccm‐mediated endocytosis. As a result, the Ccm/ICG increased the cellular uptake of Ce6 into A549 cells as compared to free ICG and potentiated the PTT efficacy both in vitro and in vivo, which might be a promising drug delivery system for advanced cancer therapy.