Attachment of Fibrinogen on Ion Beam Treated Polyurethane
Source abstract
Abstract
Protein-stable coverage of the artificial implant is a key problem for biocompatibility. In the present study, a protein layer was attached covalently to a polyurethane surface treated by an ion beam. A plasma system consisting of a vacuum chamber (0.8 Pa pressure) with a high voltage electrode powered by a short pulse (20 μS pulse duration and 200 Hz pulse repetition) generator was designed. Polyurethane with a formulation certified as a material for medical implants was treated by nitrogen ions with an energy of 20 keV and 5 × 1014–1016 ions/cm2 fluence range. Wettability measurements, X-ray photoelectron, Raman, Fourier transform infrared attenuated total reflection, and ellipsometry spectra showed a significant change in the structure of the surface layer of the treated polyurethane. The surface of the treated polyurethane contained a carbonised layer containing condensed aromatic clusters with terminal free radicals. The surface energy of polyurethane surface increased from 33 to 65 mJ/m2. The treated polyurethane surface became capable of adsorbing and chemically binding protein (fibrinogen). The designed system for ion beam treatment can be used for surface activation of biomedical polymer devices, where a total protein coverage is required.
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Research context
OpenAlex topics: Polymer Nanocomposite Synthesis and Irradiation · Electrospun Nanofibers in Biomedical Applications · Ion-surface interactions and analysis
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Institute of Continuous Media Mechanics, Ural Branch, Russian Academy of Sciences, Perm 614013, Russia
School of Medicine, University of Sydney, Camperdown, NSW 2050, Australia
Ewingar Scientific, Ewingar, NSW 2469, Australia
School of Physics, University of Sydney, Camperdown, NSW 2050, Australia
Funding
Government of the Perm Krai
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