Craniofacial Reconstruction with Personalized Lightweight Scaffold Fabricated Using Electron-Beam Additive Manufacturing
Source abstract
Abstract
Implants are the most popular option for restoring the facial anatomy in the event of a mishap. The commercially available craniofacial implants are of standard shapes, which need to be tailored and shaped to accurately fit the patient’s anatomy. The manual shaping of the implant to match the bone contours is conducted during surgical operation, and is a cumbersome and inaccurate process. Recent breakthroughs in computer-aided design, analysis, and additive manufacturing (AM) have allowed the precise and rapid manufacture of bespoke scaffolds for difficult anatomical restoration. The goal of this research is to investigate the use of scaffolds for craniofacial reconstruction and their fabrication using electron-beam additive manufacturing (EBAM). Personalized cheekbone scaffolds are additively fabricated using Ti6Al4V and subjected to compression testing. Finally, the scaffold design with the highest compressive strength is subjected to biomechanical analysis. The biomechanical analysis results indicate that the maximum Von Mises stress (40 MPa) and equivalent strain (0.4 µm) are significantly low in magnitude, thus providing a desirable implant that is both flexible and stable. The custom-designed cheekbone scaffold manufactured with AM technology not only aids in bone-implant ingrowth but also helps in reducing implant weight and ensuring implant stability and long-term effectiveness.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Dental Implant Techniques and Outcomes · Facial Trauma and Fracture Management
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Industrial Engineering, College of Engineering, King Saud University, P.O. Box 800, Riyadh 11421, Saudi Arabia
Funding
King Saud University, Researchers Supporting Project
References (32)
Show source-provided references
1. Reconstructive Surgery for Head and Neck Cancer Patients10.1155/2014/795483 ↗
2. Three-Dimensionally Printed Patient-Specific Surgical Plates Increase Accuracy of Oncologic Head and Neck Reconstruction Versus Conventional Surgical Plates: A Comparative Study10.1245/s10434-020-08732-y ↗
3. Surface Modification of Titanium, Titanium Alloys, and Related Materials for Biomedical Applications10.1016/j.mser.2004.11.001 ↗
4. Modern Metal Processing for Improved Load-Bearing Surgical Implants10.1016/0142-9612(91)90185-D ↗
5. Recent Research and Development in Metallic Materials for Biomedical, Dental and Healthcare Products Applications10.4028/www.scientific.net/MSF.539-543.193 ↗
6. de Viteri, V.S., and Fuentes, E. (2013). Titanium and Titanium Alloys as Biomaterials, InTechOpen.10.5772/55860 ↗
7. Fully Porous 3D Printed Titanium Femoral Stem to Reduce Stress-Shielding Following Total Hip Arthroplasty10.1002/jor.23445 ↗
8. Fabrication Methods of Porous Metals for Use in Orthopaedic Applications10.1016/j.biomaterials.2005.12.002 ↗
9. The Design and In Vivo Testing of a Locally Stiffness-Matched Porous Scaffold10.1016/j.apmt.2019.02.017 ↗
10. (2022, January 26). In Vivo Testing of Porous Ti-25Nb Alloy Serving as a Femoral Stem Prosthesis in a Rabbit Model. Available online: https://www.spandidos-publications.com/10.3892/etm.2016.3472.
11. Moiduddin, K., Hammad Mian, S., Alkindi, M., Ramalingam, S., Alkhalefah, H., and Alghamdi, O. (2019). An In Vivo Evaluation of Biocompatibility and Implant Accuracy of the Electron Beam Melting and Commercial Reconstruction Plates. Metals, 9.10.3390/met9101065 ↗
12. Additive Manufacturing of Bone Scaffolds10.18063/ijb.v5i1.148 ↗
13. Arcam, A.B. (2017, July 07). Electron Beam Melting—EBM Process, Additive Manufacturing. Available online: http://www.arcam.com/technology/electron-beam-melting/.
14. Chua, C.K., Wong, C.H., and Yeong, W.Y. (2017). Standards, Quality Control, and Measurement Sciences in 3D Printing and Additive Manufacturing, Academic Press.10.1016/B978-0-12-813489-4.00008-8 ↗
15. The Use of Finite Element Analysis to Enhance Research and Clinical Practice in Orthopedics10.1055/s-0035-1570114 ↗
16. Generic Finite Element Models of Orthodontic Mini-Implants: Are They Reliable?10.1016/j.jbiomech.2015.08.015 ↗
17. Rahmani, R., Antonov, M., Kollo, L., Holovenko, Y., and Prashanth, K.G. (2019). Mechanical Behavior of Ti6Al4V Scaffolds Filled with CaSiO3 for Implant Applications. Appl. Sci., 9.10.3390/app9183844 ↗
18. (2019, July 06). Materialise Mimics. Available online: https://www.materialise.com/en/medical/software/mimics.
19. Analysis of Simulated Mandibular Reconstruction Using a Segmental Mirroring Technique10.1016/j.jcms.2018.12.016 ↗
20. Moiduddin, K., Mian, S.H., Ameen, W., Alkhalefah, H., and Sayeed, A. (2021). Feasibility Study of the Cranial Implant Fabricated without Supports in Electron Beam Melting. Metals, 11.10.3390/met11030496 ↗
21. 3D Modeling, Custom Implants and Its Future Perspectives in Craniofacial Surgery10.4103/2231-0746.133065 ↗
22. Johansson, F., and Klarin, J. (2017). Mechanical Properties of Trabecular Structures Produced by SLM, as a Function of the Trabecular Morphology. [Master’s Thesis, Jönköping University].
23. Homogenization of Trabecular Structures
24. Exploring for the Optimal Structural Design for the 3D-Printing Technology for Cranial Reconstruction: A Biomechanical and Histological Study Comparison of Solid vs. Porous Structure10.1007/s00381-017-3486-y ↗
25. Froes, F.H., and Qian, M. (2018). Design of Titanium Implants for Additive Manufacturing. Titanium in Medical and Dental Applications, Woodhead Publishing.
26. Hashmi, S., Batalha, G.F., Van Tyne, C.J., and Yilbas, B. (2014). Direct Rapid Tooling. Comprehensive Materials Processing, Elsevier.
27. Al-Ahmari, A., Nasr, E.A., Moiduddin, K., Anwar, S., Kindi, M.A., and Kamrani, A. (2015). A Comparative Study on the Customized Design of Mandibular Reconstruction Plates Using Finite Element Method. Adv. Mech. Eng., 7.10.1177/1687814015593890 ↗
28. Experimental Evaluation of Relapse-Risks in Operated Zygoma Fractures10.1016/j.anl.2008.05.007 ↗
29. Toward Strong and Tough Glass and Ceramic Scaffolds for Bone Repair10.1002/adfm.201301121 ↗
30. Design and Fabrication of 3D Printed Scaffolds with a Mechanical Strength Comparable to Cortical Bone to Repair Large Bone Defects10.1038/srep19468 ↗
31. Wang, X.-M., Qiu, Z.-Y., and Cui, H. (2019). Chapter 2—Preparation and Characterization of Biomimetic Mineralized Collagen. Mineralized Collagen Bone Graft Substitutes, Woodhead Publishing.10.1016/B978-0-08-102717-2.00003-5 ↗
32. Goharian, A., Kadir, M.R.A., and Abdullah, M.R. (2017). Trauma Plating Systems: Biomechanical, Material, Biological, and Clinical Aspects, Elsevier.