Electrospun Nanofiber-Based Bioinspired Artificial Skins for Healthcare Monitoring and Human-Machine Interaction
Source abstract
Abstract
Artificial skin, also known as bioinspired electronic skin (e-skin), refers to intelligent wearable electronics that imitate the tactile sensory function of human skin and identify the detected changes in external information through different electrical signals. Flexible e-skin can achieve a wide range of functions such as accurate detection and identification of pressure, strain, and temperature, which has greatly extended their application potential in the field of healthcare monitoring and human-machine interaction (HMI). During recent years, the exploration and development of the design, construction, and performance of artificial skin has received extensive attention from researchers. With the advantages of high permeability, great ratio surface of area, and easy functional modification, electrospun nanofibers are suitable for the construction of electronic skin and further demonstrate broad application prospects in the fields of medical monitoring and HMI. Therefore, the critical review is provided to comprehensively summarize the recent advances in substrate materials, optimized fabrication techniques, response mechanisms, and related applications of the flexible electrospun nanofiber-based bio-inspired artificial skin. Finally, some current challenges and future prospects are outlined and discussed, and we hope that this review will help researchers to better understand the whole field and take it to the next level.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Advanced Sensor and Energy Harvesting Materials · Electrospun Nanofibers in Biomedical Applications · Conducting polymers and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Key Laboratory of Materials Physics of Ministry of Education, School of Physics and Microelectronics, Zhengzhou University, Zhengzhou 450001, China
Funding
China Postdoctoral Science Foundation · Foundation for Outstanding Young Teachers in Universities of Henan Province
References (100+)
Show source-provided references
1. Stretchable Thin-Film Electrodes for Flexible Electronics with High Deformability and Stretchability10.1002/adma.201405864 ↗
2. A New Class of Electronic Devices Based on Flexible Porous Substrates10.1002/advs.202105084 ↗
3. Advances in Biosensing and Environmental Monitoring Based on Electrospun Nanofibers10.1007/s42765-021-00129-0 ↗
4. Electrospun polyimide nanofibers and their applications10.1016/j.progpolymsci.2016.06.006 ↗
5. Electrochemical Sensors and Biosensors10.1021/ac202878q ↗
6. Sebum-MembraneInspired Protein-Based Bioprotonic Hydrogel for Artificial Skin and Human-Machine Merging Interface10.1002/adfm.202211056 ↗
7. Electronic Skin: Recent Progress and Future Prospects for Skin-Attachable Devices for Health Monitoring, Robotics, and Prosthetics10.1002/adma.201904765 ↗
8. Skin-inspired electronic devices10.1016/j.mattod.2014.05.006 ↗
9. A review on electrospinning for membrane fabrication: Challenges and applications10.1016/j.desal.2014.09.033 ↗
10. Intrinsically Stretchable Polymer Semiconductor Based Electronic Skin for Multiple Perceptions of Force, Temperature, and Visible Light10.1007/s12274-022-4622-x ↗
11. Superstable and Intrinsically Self-Healing Fibrous Membrane with Bionic Confined Protective Structure for Breathable Electronic Skin10.1002/ange.202200226 ↗
12. High performance piezoelectric devices based on aligned arrays of nanofibers of poly(vinylidenefluoride-co-trifluoroethylene)10.1038/ncomms2639 ↗
13. Highly Thermally Conductive Yet Electrically Insulating Polymer/Boron Nitride Nanosheets Nanocomposite Films for Improved Thermal Management Capability10.1021/acsnano.8b06290 ↗
14. Liu, X., Xu, H., Zhang, M., and Yu, D.-G. (2021). Electrospun Medicated Nanofibers for Wound Healing: Review. Membranes, 11.10.3390/membranes11100770 ↗
15. High-performance flexible pressure sensor with a self-healing function for tactile feedback10.1002/advs.202200507 ↗
16. Carbon Nanofibers Prepared via Electrospinning10.1002/adma.201104940 ↗
17. Ultralight nanofibre-assembled cellular aerogels with superelasticity and multifunctionality10.1038/ncomms6802 ↗
18. Highly Stretchable, Anti-Corrosive and Wearable Strain Sensors Based on the PDMS/CNTs Decorated Elastomer Nanofiber Composite10.1016/j.cej.2019.01.014 ↗
19. Nanofiber technology: Current status and emerging developments10.1016/j.progpolymsci.2017.03.002 ↗
20. Electrospun nanofibers: New generation materials for advanced applications10.1016/j.mseb.2017.01.001 ↗
21. Nanofibers as new-generation materials: From spinning and nano-spinning fabrication techniques to emerging applications10.1016/j.apmt.2019.06.015 ↗
22. Advances in three-dimensional nanofibrous macrostructures via electrospinning10.1016/j.progpolymsci.2013.06.002 ↗
23. Electrospun Nanofibers: New Concepts, Materials, and Applications10.1021/acs.accounts.7b00218 ↗
24. The Biomedical Use of Silk: Past, Present, Future10.1002/adhm.201800465 ↗
25. Chameleon-inspired multifunctional plasmonic nanoplatforms for biosensing applications10.1038/s41427-022-00365-9 ↗
26. Electrospinning versus fibre production methods: From specifics to technological convergence10.1039/c2cs35083a ↗
27. Wang, C., Wang, J., Zeng, L., Qiao, Z., Liu, X., Liu, H., Zhang, J., and Ding, J. (2019). Fabrication of Electrospun Polymer Nanofibers with Diverse Morphologies. Molecules, 24.10.3390/molecules24050834 ↗
28. Developments of Advanced Electrospinning Techniques: A Critical Review10.1002/admt.202100410 ↗
29. 2D and 3D electrospinning technologies for the fabrication of nanofibrous scaffolds for skin tissue engineering: A review10.1002/wnan.1626 ↗
30. Electrospun nanofiber-based glucose sensors for glucose detection10.3389/fchem.2022.944428 ↗
31. Ultrathin Hydrogel Films toward Breathable Skin-Integrated Electronics10.1002/adma.202206793 ↗
32. Electrospun polymer biomaterials10.1016/j.progpolymsci.2019.01.002 ↗
33. Breathable, washable and wearable woven-structured triboelectric nanogenerators utilizing electrospun nanofibers for biomechanical energy harvesting and self-powered sensing10.1016/j.nanoen.2020.105549 ↗
34. Zhang, M., Song, W., Tang, Y., Xu, X., Huang, Y., and Yu, D. (2022). Polymer-Based Nanofiber–Nanoparticle Hybrids and Their Medical Applications. Polymers, 14.10.3390/polym14020351 ↗
35. Liu, H., Jiang, W., Yang, Z., Chen, X., Yu, D., and Shao, J. (2022). Hybrid films prepared from a combination of electrospinning and casting for offering a dual-phase drug release. Polymers, 14.10.3390/polym14112132 ↗
36. Nanoparticles meet electrospinning: Recent advances and future prospects10.1039/c3cs60426h ↗
37. All-electrospun flexible triboelectric nanogenerator based on metallic MXene nanosheets10.1016/j.nanoen.2019.02.052 ↗
38. Continuously prepared highly conductive and stretchable SWNT/MWNT synergistically composited electrospun thermoplastic polyurethane yarns for wearable sensing10.1039/C7TC04959E ↗
39. Embedding NiS Nanoflakes in Electrospun Carbon Fibers Containing NiS Nanoparticles for Hybrid Supercapacitors10.1016/j.cej.2022.137262 ↗
40. Electrospinning and Electrospun Nanofibers: Methods, Materials, and Applications10.1021/acs.chemrev.8b00593 ↗
41. Electrospun nanofiber reinforced composites: A review10.1039/C8PY00378E ↗
42. Metallized electrospun polymeric fibers for electrochemical sensors and actuators10.1016/j.coelec.2022.101024 ↗
43. Progress of Fabrication and Applications of Electrospun Hierarchically Porous Nanofibers10.1007/s42765-022-00132-z ↗
44. Multi-functional electrospun nanofibres for advances in tissue regeneration, energy conversion & storage, and water treatment10.1039/C5CS00777A ↗
45. Nauman, S., Lubineau, G., and Alharbi, H.F. (2021). Post Processing Strategies for the Enhancement of Mechanical Properties of ENMs (Electrospun Nanofibrous Membranes): A Review. Membranes, 11.10.3390/membranes11010039 ↗
46. Multistructured Electrospun Nanofibers for Air Filtration: A Review10.1021/acsami.1c06520 ↗
47. High-performance piezoelectric composites via beta phase programming10.1038/s41467-022-32518-3 ↗
48. A fish-scale derived multifunctional nanofiber membrane for infected wound healing10.1039/D2BM00646D ↗
49. Electrospun Nanofibers of Curdlan (β-1,3 Glucan) Blend as a Potential Skin Scaffold Material10.1002/mame.201600417 ↗
50. Stretchable Electrospun PVDF-HFP/Co-ZnO Nanofibers as Piezoelectric Nanogenerators10.1038/s41598-017-19082-3 ↗
51. Fabrication of electrospun nanofibrous thermoresponsive semi-interpenetrating poly(N-isopropylacrylamide)/polyvinyl alcohol networks containing ZnO nanoparticle mats: Characterization and antibacterial and cytocompatibility evaluation10.1039/D2TB02179J ↗
52. Recent advances in electrospun nanofibers for supercapacitors10.1039/D0TA05100D ↗
53. Recent advances in morphology, aperture control, functional control and electrochemical sensors applications of carbon nanofibers10.1016/j.ab.2022.114882 ↗
54. Lipase immobilization on a novel class of Zr-MOF/electrospun nanofibrous polymers: Biochemical characterization and efficient biodiesel production10.1016/j.ijbiomac.2021.10.106 ↗
55. Tailoring moisture electroactive Ag/Zn@cotton coupled with electrospun PVDF/PS nanofibers for antimicrobial face masks10.1016/j.jhazmat.2022.128239 ↗
56. Shape memory effect on electrospun PLA-based fibers tailoring their thermal response10.1016/j.eurpolymj.2019.05.014 ↗
57. Design and characterization of keratin/PVA-PLA nanofibers containing hybrids of nanofibrillated chitosan/ZnO nanoparticles10.1016/j.ijbiomac.2021.07.160 ↗
58. Fabrication and characterization of mucoadhesive bioplastic patch via coaxial polylactic acid (PLA) based electrospun nanofibers with antimicrobial and wound healing application10.1016/j.ijbiomac.2021.01.051 ↗
59. Formation and Investigation of Electrospun PLA Materials with Propolis Extracts and Silver Nanoparticles for Biomedical Applications
60. Munawar, M.A., and Schubert, D.W. (2021). Revealing Electrical and Mechanical Performances of Highly Oriented Electrospun Conductive Nanofibers of Biopolymers with Tunable Diameter. Int. J. Mol. Sci., 22.10.3390/ijms221910295 ↗
61. Polyaniline-polycaprolactone fibers for neural applications: Electroconductivity enhanced by pseudo-doping10.1016/j.msec.2020.111680 ↗
62. Optimizing the electrical conductivity of polyacrylonitrile/polyaniline with nickel nanoparticles for the enhanced electrostimulation of Schwann cells proliferation10.1016/j.bioelechem.2021.107750 ↗
63. Munawar, M.A., and Schubert, D.W. (2022). Thermal-Induced Percolation Phenomena and Elasticity of Highly Oriented Electrospun Conductive Nanofibrous Biocomposites for Tissue Engineering. Int. J. Mol. Sci., 23.10.3390/ijms23158451 ↗
64. Bi(2)S(3)/PVDF/Ppy-Based Freestanding, Wearable, Transient Nanomembrane for Ultrasensitive Pressure, Strain, and Temperature Sensing10.1021/acsabm.0c01399 ↗
65. Fabrication and characterization of conductive polypyrrole/chitosan/collagen electrospun nanofiber scaffold for tissue engineering application10.1016/j.ijbiomac.2020.12.031 ↗
66. Assembly of DNA-unctionalized gold nanoparticles on electrospun nanofibers as a fluorescent sensor for nucleic acids10.1039/c3cc41753k ↗
67. Mechanism of a long-term controlled drug release system based on simple blended electrospun fibers10.1016/j.jconrel.2020.01.020 ↗
68. Antimicrobial electrospun nanofiber mats of NaOH-hydrolyzed chitosan (HCS)/PVP/PVA incorporated with in-situ synthesized AgNPs: Fabrication, characterization, and antibacterial activity10.1016/j.ijbiomac.2021.08.209 ↗
69. Functionalized electrospun nanofibers for high efficiency removal of particulate matter10.1038/s41598-022-12505-w ↗
70. Fabrication of stable electrospun blended chitosan-poly(vinyl alcohol) nanofibers for designing naked-eye colorimetric glucose biosensor based on GOx/HRP10.1016/j.ijbiomac.2021.10.048 ↗
71. Simultaneous trace-level monitoring of seven opioid analgesic drugs in biological samples by pipette-tip micro solid phase extraction based on PVA-PAA/CNT-CNC composite nanofibers followed by HPLC-UV analysis10.1007/s00604-021-04931-w ↗
72. Preparation of carboxymethyl starch/polyvinyl-alcohol electrospun composite nanofibers from a green approach10.1016/j.ijbiomac.2021.09.015 ↗
73. Preparation and performance evaluation of chitosan/polyvinylpyrrolidone/polyvinyl alcohol electrospun nanofiber membrane for heavy metal ions and organic pollutants removal10.1016/j.ijbiomac.2022.05.017 ↗
74. Chitosan/Gold Hybrid Nanoparticles Enriched Electrospun PVA Nanofibrous Mats for the Topical Delivery of Punica granatum L. Extract: Synthesis, Characterization, Biocompatibility and Antibacterial Properties10.2147/IJN.S306526 ↗
75. Paclitaxel-loaded lignin particle encapsulated into electrospun PVA/PVP composite nanofiber for effective cervical cancer cell inhibition10.1088/1361-6528/abb55a ↗
76. Fabrication of Mesoporous Silica Nanoparticle–Incorporated Coaxial Nanofiber for Evaluating the In Vitro Osteogenic Potential10.1007/s12010-021-03741-3 ↗
77. Enhanced mechanical properties and electrical conductivity of Chitosan/Polyvinyl Alcohol electrospun nanofibers by incorporation of graphene nanoplatelets10.1016/j.jmbbm.2021.104975 ↗
78. Electrospun gelatin nanofiber based self-powered bio-e-skin for health care monitoring10.1016/j.nanoen.2017.04.028 ↗
79. Fabrication of polyvinylidene fluoride (PVDF) nanofiber membranes by electro-spinning for direct contact membrane distillation10.1016/j.memsci.2012.09.023 ↗
80. Highly Durable Nanofiber-Reinforced Elastic Conductors for Skin-Tight Electronic Textiles10.1021/acsnano.9b02297 ↗
81. He, Z., Rault, F., Lewandowski, M., Mohsenzadeh, E., and Salaun, F. (2021). Electrospun PVDF Nanofibers for Piezoelectric Applications: A Review of the Influence of Electrospinning Parameters on the β Phase and Crystallinity Enhancement. Polymers, 13.10.3390/polym13020174 ↗
82. Castkova, K., Kastyl, J., Sobola, D., Petrus, J., Stastna, E., Riha, D., and Tofel, P. (2020). Structure-Properties Relationship of Electrospun PVDF Fibers. Nanomaterials, 10.10.3390/nano10061221 ↗
83. Ultrasensitive aptasensor using electrospun MXene/polyvinylidene fluoride nanofiber composite for Ochratoxin A detection10.1016/j.foodchem.2022.133105 ↗
84. Porous Electrospun Fibers Embedding TiO2 for Adsorption and Photocatalytic Degradation of Water Pollutants10.1021/acs.est.7b06508 ↗
85. Nanofiber web textile dry electrodes for long-term biopotential recording10.1109/TBCAS.2012.2201154 ↗
86. Facile Strategy for Fabrication of Flexible, Breathable, and Washable Piezoelectric Sensors via Welding of Nanofibers with Multiwalled Carbon Nanotubes (MWCNTs)10.1021/acsami.9b10886 ↗
87. Polyvinylidene fluoride/silk fibroin-based bio-piezoelectric nanofibrous scaffolds for biomedical application10.1002/term.3232 ↗
88. Kaspar, P., Sobola, D., Castkova, K., Knapek, A., Burda, D., Orudzhev, F., Dallaev, R., Tofel, P., Trcka, T., and Grmela, L. (2020). Characterization of Polyvinylidene Fluoride (PVDF) Electrospun Fibers Doped by Carbon Flakes. Polymers, 12.10.3390/polym12122766 ↗
89. Flexible Nanogenerator from Electrospun PVDF-Polycarbazole Nanofiber Membranes for Human Motion Energy-Harvesting Device Applications10.1021/acsbiomaterials.0c01730 ↗
90. Electrospun lignin-PVP nanofibers and their ability for structuring oil10.1016/j.ijbiomac.2021.03.069 ↗
91. Boosting piezoelectric response of PVDF-TrFE via MXene for self-powered linear pressure sensor10.1016/j.compscitech.2020.108600 ↗
92. All electrospun fabrics based piezoelectric tactile sensor10.1088/1361-6528/ac7ed5 ↗
93. Electrospun PVDF-TrFE/MXene Nanofiber Mat-Based Triboelectric Nanogenerator for Smart Home Appliances10.1021/acsami.0c17512 ↗
94. A novel PVDF-TiO(2)@g-C(3)N(4) composite electrospun fiber for efficient photocatalytic degradation of tetracycline under visible light irradiation10.1016/j.ecoenv.2020.111866 ↗
95. Enhanced piezoelectric and photocatalytic performance of flexible energy harvester based on CsZn0.75Pb0.25I3/CNC–PVDF composite nanofibers10.1016/j.cej.2021.133620 ↗
96. High-performance triboelectric nanogenerator based on MXene functionalized polyvinylidene fluoride composite nanofibers10.1016/j.nanoen.2020.105670 ↗
97. Cowpea-structured PVDF/ZnO nanofibers based flexible self-powered piezoelectric bending motion sensor towards remote control of gestures10.1016/j.nanoen.2018.10.049 ↗
98. High-performance triboelectric nanogenerator based on electrospun PVDF-graphene nanosheet composite nanofibers for energy harvesting10.1016/j.nanoen.2020.105599 ↗
99. Synergistic effect of graphene nanosheet and BaTiO3 nanoparticles on performance enhancement of electrospun PVDF nanofiber mat for flexible piezoelectric nanogenerators10.1016/j.nanoen.2018.07.053 ↗
100. A stretchable strain sensor based on a metal nanoparticle thin film for human motion detection10.1039/C4NR03295K ↗