Fibrotic infarction on the LV free wall may alter the mechanics of healthy septal wall during passive filling
Source abstract
Abstract
The effect of myocardial infarction on the global functioning of the heart is well known. Less is understood regarding the effect of LV fibrotic infarction on the cardiac mechanics of the septal wall. To determine this unknown, the stress and strain of septal wall on the healthy and infarcted rat heart model is measured by using finite element models of rat heart geometries. The main objective of this study was to utilized computational methods to study the effect of LV free wall fibrotic infarction on the healthy septal wall. Three-dimensional biventricular rat heart geometries were developed from cardiac magnetic resonance images of a healthy heart and a heart with left ventricular (LV) fibrotic infarction after infarct induction. From these geometries, FE models were established. Three-dimensional biventricular rat heart geometries developed from cardiac magnetic resonance images were used in creating FE models of healthy and infarcted rat hearts. The average radial strain percentage change of the healthy septal wall on the epicardium, mid-wall and endocardium was 61%, 52% and 14% higher than the infarcted septal wall, respectively. It was concluded that the fibrotic infarction has a potential cause the malfunction of the heart due to high myocardial stress and strain that the septal wall experiences.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Cardiac Structural Anomalies and Repair · Elasticity and Material Modeling · Cardiovascular Function and Risk Factors
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Mechanical and Industrial Engineering, College of science, Engineering and Technology, University of South Africa, Florida, 1710, South Africa. Tel.: ; Fax: ; E-mail: masitfj@unisa.ac.za
References (44)
Show source-provided references
1. Dilated cardiomyopathy is associated with an increase in the type I/type III collagen ratio: A quantitative assessment10.1016/0735-1097(94)00557-7 ↗
2. Histopathologic findings in explanted heart tissue from patients with end-stage idiopathic dilated cardiomyopathy10.1111/j.1432-2277.2001.tb00063.x ↗
3. Analysis of healing after myocardial infarction using polarized light microscopy
4. Losartan-dependent regression of myocardial fibrosis is associated with reduction of left ventricular chamber stiffness in hypertensive patients10.1161/01.CIR.0000017264.66561.3D ↗
5. Myocardial fibrosis and stiffness with hypertrophy and heart failure in the spontaneously hypertensive rat10.1161/01.CIR.91.1.161 ↗
6. Evaluation of diffuse myocardial fibrosis in heart failure with cardiac magnetic resonance contrast-enhanced T1 mapping10.1016/j.jacc.2008.06.049 ↗
7. Quantitative morphologic findings of the myocardium in idiopathic dilated cardiomyopathy10.1016/S0002-9149(83)80088-5 ↗
8. Effects of loop diuretics on myocardial fibrosis and collagen type I turnover in chronic heart failure10.1016/j.jacc.2003.12.052 ↗
9. Cardiovascular magnetic resonance, fibrosis, and prognosis in dilated cardiomyopathy10.1016/j.jacc.2006.07.049 ↗
10. Gadolinium cardiovascular magnetic resonance predicts reversible myocardial dysfunction and remodeling in patients with heart failure undergoing β-blocker therapy10.1161/01.CIR.0000095029.57483.60 ↗
11. Gender differences in survival in patients with severe left ventricular dysfunction despite similar extent of myocardial scar measured on cardiac magnetic resonance10.1093/eurjhf/hfp118 ↗
12. Impact of unrecognized myocardial scar detected by cardiac magnetic resonance imaging on event-free survival in patients presenting with signs or symptoms of coronary artery disease10.1161/CIRCULATIONAHA.105.570648 ↗
13. Impact of myocardial fibrosis in patients with symptomatic severe aortic stenosis10.1161/CIRCULATIONAHA.108.847772 ↗
14. Diastolic heart failure evidence of increased myocardial collagen turnover linked to diastolic dysfunction10.1161/CIRCULATIONAHA.106.638569 ↗
15. Quantitative analysis of myocardial fibrosis in normals, hypertensive hearts, and hypertrophic cardiomyopathy10.1136/hrt.55.6.575 ↗
16. 10.1115/IMECE2015-5000310.1115/IMECE2015-50003 ↗
17. F. Masithulela, The effect of over-loaded right ventricle during passive filling in rat heart: A biventricular finite element model, in: ASME 2015 International Mechanical Engineering Congress and Exposition, 2015, pp. V003T03A005–V003T03A005.
18. The effect of hydrogel injection on cardiac function and myocardial mechanics in a computational post-infarction model10.1080/10255842.2012.656611 ↗
19. Outcomes of myocardial infarction hydrogel injection therapy in the human left ventricle dependent on injectate distribution10.1002/cnm.2551 ↗
20. Computational predictions of improved of wall mechanics and function of the infarcted left ventricle at early and late remodelling stages: Comparison of layered and bulk hydrogel injectates10.12989/aba.2013.1.1.041 ↗
21. The beneficial effects of deferred delivery on the efficiency of hydrogel therapy post myocardial infarction10.1016/j.biomaterials.2011.11.031 ↗
22. Micro-structurally detailed model of a therapeutic hydrogel injectate in a rat biventricular cardiac geometry for computational simulations10.1080/10255842.2013.793765 ↗
23. Characterisation of the mechanical properties of infarcted myocardium in the rat under biaxial tension and uniaxial compression10.1016/j.jmbbm.2016.06.029 ↗
24. P. Wise, N.H. Davies, M.S. Sirry, J. Kortsmit, L. Dubuis, C.K. Chai et al., Excessive volume of hydrogel injectates may compromise the efficacy for the treatment of acute myocardial infarction, in: International Journal for Numerical Methods in Biomedical Engineering, 2016.10.1002/cnm.2772 ↗
25. Three-dimensional stress and strain in passive rabbit left ventricle: A model study10.1114/1.1289469 ↗
26. 10.1155/2012/50403710.1155/2012/504037 ↗
27. 10.1115/1.300516110.1115/1.3005161 ↗
28. Measurement of strain and analysis of stress in resting rat left ventricular myocardium10.1016/0021-9290(93)90030-I ↗
29. Finite element stress analysis of left ventricular mechanics in the beating dog heart10.1016/0021-9290(94)00174-3 ↗
30. Coupling of a 3D finite element model of cardiac ventricular mechanics to lumped systems models of the systemic and pulmonic circulation10.1007/s10439-006-9212-7 ↗
31. Remodeling in myocardium adjacent to an infarction in the pig left ventricle10.1152/ajpheart.00160.2004 ↗
32. Structure and mechanics of healing myocardial infarcts10.1146/annurev.bioeng.7.060804.100453 ↗
33. Modelling cardiac mechanical properties in three dimensions10.1098/rsta.2001.0828 ↗
34. Mathematical modelling of the heart: Cell to organ10.1016/S0960-0779(01)00170-9 ↗
35. Computational mechanics of the heart10.1023/A:1011084330767 ↗
36. Effects of biventricular pacing and scar size in a computational model of the failing heart with left bundle branch block10.1016/j.media.2008.06.013 ↗
37. 10.1007/978-3-642-72474-9_2610.1007/978-3-642-72474-9_26 ↗
38. Enhanced deposition of predominantly type I collagen in myocardial disease10.1016/0022-2828(90)90079-H ↗
39. Interstitial fibrosis in the dilated non-ischaemic myocardium10.1136/heart.89.10.1255 ↗
40. Idiopathic dilated cardiomyopathy: Analysis of 152 necropsy patients10.1016/0002-9149(87)90618-7 ↗
41. Mechanisms and models in heart failure the biomechanical model and beyond10.1161/CIRCULATIONAHA.104.500546 ↗
42. Mechanics of the single left ventricle a study in ventricular-ventricular interaction II10.1161/01.CIR.98.4.330 ↗
43. A constitutive relation for passive right-ventricular free wall myocardium10.1016/0021-9290(93)90357-K ↗
44. Biaxial mechanical properties of passive right ventricular free wall myocardium10.1115/1.2894122 ↗