Human adipose-derived stem cells can optimize the filling material in rats
Source abstract
Abstract
BACKGROUND: Human adipose-derived stem cells have been identified as a promising candidate for cell-assisted therapy to improve graft survival. OBJECTIVE: To objective of the study was to add human adipose-derived stem cells into filling materials. METHODS: The filling materials were prepared and divided into 6 groups: fat particles with phosphate buffer saline or human adipose-derived stem cells; acellular dermal matrix particles with phosphate buffer saline or human adipose-derived stem cells; mixture of fat particles and acellular dermal matrix particles with phosphate buffer saline or human adipose-derived stem cells. The survival rate, vascular density and histological at 2, 6 and 12 weeks were investigated. RESULTS: Human adipose-derived stem cells significantly improved survival rate in each group at 6 and 12 weeks, and it significantly increased the vascular density in the fat particles and porcine acellular dermal matrix combined group and porcine acellular dermal matrix group at three time points, but human adipose-derived stem cells did not have a significant effect in the fat particles group. CONCLUSION: Human adipose-derived stem cells as assisted cells added into filling material can improve survival rate and vascular density in rats.
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Research context
OpenAlex topics: Mesenchymal stem cell research · Tissue Engineering and Regenerative Medicine · Wound Healing and Treatments
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
, , Chinese Academy of Medical Sciences and Peking Union Medical College, , China
References (20)
Show source-provided references
1. Filling the midface: Injectables10.1055/s-0036-1586207 ↗
2. Aesthetic leaders in facial aesthetics consensus C. Facial assessment and injection guide for botulinum toxin and injectable hyaluronic acid fillers: Focus on the upper face10.1097/PRS.0000000000003544 ↗
3. Autogenous fat transplantation and botulinum toxin injection into the Masseter muscle to create an ideal oval face10.1093/asj/sjaa324 ↗
4. The use of acellular dermal matrix in breast reconstruction: Evolution of techniques over 2 decades10.21037/gs.2018.10.05 ↗
5. Acellular dermal matrix in the management of the burn patient10.1177/1090820X11418202 ↗
6. Human acellular dermal wound matrix for treatment of DFU: Literature review and analysis
7. A potential filling material for wound healing and shaping: Acellular dermal matrix combined with autologous dermis10.1007/s00266-019-01516-0 ↗
8. Hopes and limits of adipose-derived stem cells (ADSCs) and mesenchymal stem cells (MSCs) in wound healing10.3390/ijms21041306 ↗
9. Human adipose-derived stem cells enriched with VEGF-modified mRNA promote angiogenesis and long-term graft survival in a fat graft transplantation model10.1186/s13287-020-02008-8 ↗
10. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement10.1080/14653240600855905 ↗
11. Therapeutic mechanisms of human adipose-derived mesenchymal stem cells in a rat tendon injury model10.1177/0363546517689874 ↗
12. Application of adipose-derived stem cells in photoaging: Basic science and literature review10.1186/s13287-020-01994-z ↗
13. Mesenchymal-stem-cell-based experimental and clinical trials: Current status and open questions10.1517/14712598.2011.574119 ↗
14. Human adipose-derived mesenchymal stem cells can survive and integrate into the adult rat eye following xenotransplantation10.1111/xen.12033 ↗
15. Autologous fat transplantation for breast reconstruction: A literature review10.1016/j.amsu.2016.11.012 ↗
16. Fat chance: The rejuvenation of irradiated skin10.1097/GOX.0000000000002092 ↗
17. Comparison of three different fat graft preparation methods: Gravity separation, centrifugation, and simultaneous washing with filtration in a closed system10.1097/PRS.0b013e31828276e9 ↗
18. The fate of adipocytes after nonvascularized fat grafting: Evidence of early death and replacement of adipocytes10.1097/PRS.0b013e31824a2b19 ↗
19. Enrichment of autologous fat grafts with ex-vivo expanded adipose tissue-derived stem cells for graft survival: A randomised placebo-controlled trial10.1016/S0140-6736(13)61410-5 ↗
20. Adipose-derived stem/progenitor cells: Roles in adipose tissue remodeling and potential use for soft tissue augmentation10.2217/17460751.4.2.265 ↗