Quantification of the chemical composition variations of tumors in photothermal therapy by photoacoustic spectroscopy: An in vitro study
Source abstract
Abstract
In this study, the change of tumors' chemical composition in the temperature range of 20∼70°C is quantified for photothermal tumor therapy by photoacoustic spectroscopy (PAS) with the wavelengths of 700∼1000 nm. Based on the measured photoacoustic signals, two absorption peaks at the wavelengths of 750nm and 950nm are identified. It is also observed that high temperature (>55°C) is able to induce the physical and chemical degeneration of tumors. According to the in vitro tests, a new chemical species, met-hemoglobin, which is absent in normal blood, is generated at high temperature with enhanced near-infrared absorption.
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Research context
OpenAlex topics: Photoacoustic and Ultrasonic Imaging · Thermography and Photoacoustic Techniques · Spectroscopy Techniques in Biomedical and Chemical Research
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Affiliations
Bioimaging Core, Faculty of Health Sciences, University of Macau, Macau SAR, China
College of Photonic and Electronic Engineering, Fujian Normal University, Fuzhou 350007, China
References
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