Combating liver cancer through GO-targeted biomaterials
Source abstract
Abstract
Abstract Hydroxycamptothecin (HCPT) is a topoisomerase I inhibitor, and it has been widely used clinically in the treatment of primary liver cancer, gastric cancer, and other tumors. The clinical application of HCPT is limited by its water solubility, and it has certain toxicity to patients with tumor. Therefore, the effective tumor site accumulation of HCPT is necessary. This work studied the inhibitory effect of HCPT on the proliferation and migration of human liver cancer cells (HepG-2) and used carboxymethyl chitosan (CMC) and hyaluronic acid (HA) to modify graphene oxide (GO) as nano-carrier materials, which load HCPT to achieve a drug delivery system for liver tumors with good biocompatibility and high drug loading. HCPT can significantly inhibit proliferation and migration of HepG-2, enhance the release of reactive oxygen species, reduce mitochondrial membrane potential, and induce apoptosis. The GO-CMC-HA/HCPT drug delivery system enabled HepG-2 to uptake more HCPT, thereby inhibiting its proliferation and improving the efficacy of HCPT in vivo and in vitro . This study explored a potential therapy strategy by preparing a GO-based tumor-targeted drug delivery system.
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Research context
OpenAlex topics: Graphene and Nanomaterials Applications · Nanoparticle-Based Drug Delivery · Nanoplatforms for cancer theranostics
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (37)
Show source-provided references
1. Hydroxycamptothecin-induced apoptosis in hepatoma SMMC-7721 cells and the role of mitochondrial pathway10.1016/j.mito.2006.07.005 ↗
2. Accumulation of camptothecin and 10-hydroxycamptothecin and the transcriptional expression of camptothecin biosynthetic genes in Camptotheca acuminata cambial meristematic and dedifferentiated cells10.1039/C7RA00588A ↗
3. Assessment of the size of sella turcica in relation to the internal measurements of the skull
4. Menthol-modified casein nanoparticles loading 10-hydroxycamptothecin for glioma targeting therapy10.1016/j.apsb.2019.01.006 ↗
5. DNA damage and cell killing by camptothecin and its derivative in human leukemia HL-6 cells10.1111/j.1349-7006.1993.tb00177.x ↗
6. Development of a chemically stable 10-hydroxycamptothecin nanosuspensions10.1016/j.ijpharm.2009.05.062 ↗
7. Development and validation of a RP-HPLC method with fluorescence detection for simultaneous determination of 10-methoxycamptothecin and its metabolite 10-hydroxycamptothecin in rat plasma10.1016/j.jchromb.2012.07.001 ↗
8. Tissue distribution and anti-lung cancer effect of 10-hydroxycamptothecin combined with platycodonis radix and glycyrrhizae radix ET Rhizoma10.3390/molecules24112068 ↗
9. Pharmaceutical evaluation of hydroxycamptothecin nanosuspensions with the action of inhibiting P-gp10.1631/jzus.B1000135 ↗
10. Carrier-free, functionalized drug nanoparticles for targeted drug delivery10.1039/c2cc33214k ↗
11. Cytotoxicity of pharmaceutically optimized nanometric systems of a chemotherapeutic drug on breast and liver tumor cells
12. The effect of hydroxycamptothecin and pingyangmycin on human squamous cell carcinoma of the tongue10.3892/ol.2013.1109 ↗
13. Polymeric micelle systems of hydroxycamptothecin based on amphiphilic N-alkyl-N-trimethyl chitosan derivatives10.1016/j.colsurfb.2006.11.031 ↗
14. Graphene-based nanomaterials and their potentials in advanced drug delivery and cancer therapy10.1016/j.jconrel.2018.07.034 ↗
15. A tumor vascular-targeted interlocking trimodal nanosystem that induces and exploits hypoxia10.1002/advs.201800034 ↗
16. A smart MnO2-doped graphene oxide nanosheet for enhanced chemo-photodynamic combinatorial therapy via simultaneous oxygenation and glutathione depletion10.1016/j.apsb.2020.07.021 ↗
17. Preparation and properties of hydroxycamptothecin-loaded nanoparticles made of amphiphilic copolymer and normal polymer10.1016/j.jcis.2009.04.080 ↗
18. Enhanced drug loading capacity of 10-hydroxycamptothecin-loaded nanoparticles prepared by two-step nanoprecipitation method10.1016/j.jddst.2016.09.012 ↗
19. The chemistry of graphene oxide10.1039/B917103G ↗
20. Carbon nanotubes as intracellular transporters for proteins and DNA: an investigation of the uptake mechanism and pathway10.1002/anie.200503389 ↗
21. Evaluation of pegylated lipid nanocapsules versus complement system activation and macrophage uptake10.1002/jbm.a.30711 ↗
22. Recent advances in stealth coating of nanoparticle drug delivery systems10.1002/wnan.1157 ↗
23. Poly(amino acid)s: promising enzymatically degradable stealth coatings for liposomes10.1016/j.ijpharm.2006.11.018 ↗
24. Repeated injections of PEG-PE liposomes generate anti-PEG antibodies10.1109/ICASSP.2011.5946843 ↗
25. Anti-PEG immunity: emergence, characteristics, and unaddressed questions10.1002/wnan.1339 ↗
26. Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives10.1002/anie.200902672 ↗
27. Recent advances in hyluronic acid-decorated nanocarriers for targeted cancer therapy10.1016/j.drudis.2016.12.009 ↗
28. Repeated administration of hyaluronic acid coated liposomes with improved pharmacokinetics and reduced immune response10.1021/acs.molpharmaceut.5b00952 ↗
29. Liposome-encapsulated doxorubicin targeted to CD44: a strategy to kill CD44-overexpressing tumor cells10.1002/1097-0142(20010315)91:6<1185::AID-CNCR1116>3.0.CO;2-Q ↗
30. Structure of graphite oxide revisited10.1021/jp9731821 ↗
31. Software news and update AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading10.1002/jcc.21334 ↗
32. Antibacterial ability and hemocompatibility of graphene functionalized germanium10.1038/srep37474 ↗
33. Safe and efficient membrane permeabilizing polymers based on PLLA for antibacterial applications10.1039/C6RA04531F ↗
34. Biodegradable self-assembled nanoparticles of poly (D,L-lactide-co-glycolide)/hyaluronic acid block copolymers for target delivery of docetaxel to breast cancer10.1016/j.biomaterials.2013.09.089 ↗
35. Cytotoxicity of graphene oxide and graphene in human erythrocytes and skin fibroblasts10.1021/am200428v ↗
36. Doxorubicin loaded pH-sensitive polymeric micelles for reversal of resistant MCF-7 tumor10.1016/j.jconrel.2004.12.018 ↗
37. Hydroxycamptothecin induces apoptosis and inhibits tumor growth in colon cancer by the downregulation of survivin and XIAP expression10.1186/1477-7819-11-120 ↗