Structural characteristics of polysaccharide microcapsules from Nostoc commune, and their applications in skin wound healing and pathological repair
Source abstract
Abstract
Abstract In this study, the extraction conditions of Nostoc commune Vauch polysaccharide (NCVP) were optimized by single factor and orthogonal experiments. Then, the NCVP microcapsules (NCVPM) were prepared. After analyzing the microcapsule structural and thermal characteristics, the skin wound healing ability was studied by establishing back trauma rat models. Results showed that the NCVP yield was 10.37% under the following optimum conditions: 210 min extraction time, solid–liquid ratio of 1:50 and extraction temperature of 90 °C. The overall performance of the microcapsule was the best when the concentration of sodium alginate, calcium chloride and chitosan was 2%, 3% and 0.3%, respectively. NCVPM had spherical morphology, typical microcapsule structural characteristics and good thermal stability, and NCVP was dispersed in the microcapsules. NCVPM showed good biocompatibility and biodegradability, which met the requirements for slow-release polymer materials. After 14 days of treatment, the wound healing rate was 92.4%, the cells were arranged neatly and regularly, the cell nucleus became large and elliptical, the cell had a tendency to divide, and the fibers and microvessel were significantly more. By evaluating the mechanism, NCVPM could increase the content of hydroxyproline and glutathione to protect cells from oxidative damage, leading in turn to accelerated wound healing and shorter wound healing times. It could also accelerate cell division, collagen and microvascular production by increasing transcription levels of vascular endothelial growth factor mRNA and miRNA-21.
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Research context
OpenAlex topics: Wound Healing and Treatments · Periodontal Regeneration and Treatments · Acupuncture Treatment Research Studies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (51)
Show source-provided references
1. Structural characterisation of a complex heteroglycan from the cyanobacterium Nostoc commune10.1016/j.carbpol.2012.08.063 ↗
2. Research on status quo and applied prospect of nostoc sphaeroides kü tzing
3. Mechanisms underlying the effect of polysaccharides in the treatment of type 2 diabetes: a review10.1016/j.carbpol.2016.02.040 ↗
4. Hypocholesterolemic effect of blue-green alga, Ishikurage Nostoc commune in rats fed atherogenic die10.1007/BF01091230 ↗
5. In vitro antiviral activity of sulfated Auricularia auricula polysaccharides10.1016/j.carbpol.2012.06.060 ↗
6. Antimicrobial and anti-inflammatory properties of nostocionone isolated from Nostoc commune Vauch and its derivatives against Propionibacterium acnes10.1016/j.anaerobe.2014.03.006 ↗
7. Antioxidant and moisture-retention activities of the polysaccharide from Nostoc commune10.1016/j.carbpol.2010.10.046 ↗
8. Emerging progress on the mechanism and technology in wound repair10.1016/j.biopha.2019.109191 ↗
9. Thermosensitive biomimetic polyisocyanopeptide hydrogels may facilitate wound repair10.1016/j.biomaterials.2018.07.038 ↗
10. Repair of dense connective tissues via biomaterial-mediated matrix reprogramming of the wound interface10.1016/j.biomaterials.2014.10.067 ↗
11. Effect and mechanism of thyme microcapsules on histamine production by Morganella morganii MN483274 during the processing of smoked horse meat sausage10.1016/j.foodcont.2020.107615 ↗
12. Application of microencapsulated essential oils in cosmetic and personal healthcare products—a review10.1111/ics.12232 ↗
13. Carboxymethyl tara gum-lactoferrin complex coacervates as carriers for vitamin D3: encapsulation and controlled release—sciencedirect
14. Bioinspired oral insulin delivery system using yeast microcapsules10.1016/j.msec.2019.109753 ↗
15. Influence of different divalent ions cross-linking sodium alginate-polyacrylamide hydrogels on antibacterial properties and wound healing10.1016/j.carbpol.2018.05.078 ↗
16. Two-step method for encapsulation of oregano essential oil in chitosan nanoparticles: preparation, characterization and in vitro release study10.1016/j.carbpol.2013.02.031 ↗
17. Bromelain-loaded chitosan nanofibers prepared by electrospinning method for burn wound healing in animal models10.1016/j.lfs.2019.05.028 ↗
18. Preparation and characterisation of a novel silk fibroin/hyaluronic acid/sodium alginate scaffold for skin repair10.1016/j.ijbiomac.2019.02.120 ↗
19. Preparation and characterization of self-healing microcapsules embedding waterborne epoxy resin and curing agent for asphalt materials10.1016/j.conbuildmat.2018.06.185 ↗
20. Optimization for the extraction of polysaccharides from Nostoc commune and its antioxidant and antibacterial activities10.1016/j.jtice.2015.02.004 ↗
21. Purification, partial characterization and antioxidant activity of polysaccharides from Glycyrrhiza Uralensis10.1016/j.ijbiomac.2015.05.060 ↗
22. Polysaccharides from fruit calyx of Physalis alkekengi var. francheti: isolation, purification, structural features and antioxidant activities10.1016/j.carbpol.2008.12.020 ↗
23. Preparation optimization and characterization of chitosan-tripolyphosphate microcapsules for the encapsulation of herbal galactagogue extract10.1016/j.ijbiomac.2019.08.122 ↗
24. Collagen matrices containing poly (vinyl alcohol) microcapsules with retinyl palmitate—structure, stability, mechanical and swelling properties10.1016/j.polymdegradstab.2019.01.019 ↗
25. Fabrication of the polyphosphates patched cellulose sulfate-chitosan hydrochloride microcapsules and as vehicles for sustained drug release10.1016/j.ijpharm.2018.11.058 ↗
26. Preparation and characterization of novel chitosan and β-cyclodextrin polymer sponges for wound dressing applications10.1016/j.carbpol.2017.06.026 ↗
27. Pyrolysis characteristics and kinetic studies of horse manure using thermogravimetric analysis10.1016/j.enconman.2018.11.071 ↗
28. Wound healing effect of an Astragalus membranaceus polysaccharide and its mechanism10.3892/mmr.2017.6488 ↗
29. Prognostic impact of angiogenesis in nonmuscle invasive bladder cancer as defined by microvessel density after immunohistochemical staining for CD3410.3109/01913123.2012.672847 ↗
30. Immunohistochemical expression of CD34 for characterization and quantification of mucosal vasculature and its probable role in malignant transformation of atrophic epithelium in oral submucous fibrosis10.1016/j.oraloncology.2010.04.004 ↗
31. Immunohistochemical investigation of the angiogenic proteins VEGF, HIF-1α and CD34 in invasive ductal carcinoma of the breast10.1016/j.acthis.2013.06.005 ↗
32. miRNA-directed regulation of VEGF in tilapia under hypoxia condition10.1016/j.bbrc.2014.10.068 ↗
33. Optimised lyophilisation—based method for different biomolecule single-extractions from the same rat brain sample: suitability for RNA and protein expression analyses after ischemic stroke10.1016/j.jneumeth.2019.108402 ↗
34. Optimization of RNA extraction protocol for long-term archived formalin-fixed paraffin-embedded tissues of horses10.1016/j.yexmp.2019.104289 ↗
35. Drug release of yolk/shell microcapsule controlled by pH-responsive yolk swelling10.1016/j.cej.2017.06.170 ↗
36. Swelling characteristics and textural properties of two kinds of sodium alginate-based hydrogels
37. Encapsulation of Satureja hortensis L. (Lamiaceae) in chitosan/TPP nanoparticles with enhanced acaricide activity against Tetranychus urticae Koch (Acari: Tetranychidae)10.1016/j.ecoenv.2018.05.051 ↗
38. Nanocapsules of biodegradable polymers: preparation and characterization by direct high resolution electron microscopy10.1016/S0928-4931(02)00073-5 ↗
39. Solid state characterization of the structure of chitosan films, Journal of Polymer10.1002/pol.1981.180190706 ↗
40. Self-cleaning pH/thermo responsive cotton fabric with smart-control and reusable functions for oil/water separation10.1039/C6RA02252A ↗
41. Preparation and characterization of citrus essential oils loaded in chitosan microcapsules by using different emulsifiers10.1016/j.jfoodeng.2017.08.026 ↗
42. Studies on chitosan: 3. Evidence for the presence of random and block copolymer structures in partially N-acetylated chitosans10.1016/0141-8130(91)90008-I ↗
43. Smad3 and extracellular signal-regulated kinase 1/2 coordinately mediate transforming growth factor-beta-induced expression of connective tissue growth factor in human fibroblasts10.1111/j.0022-202X.2005.23750.x ↗
44. Mechanism of sustained release of vascular endothelial growth factor in accelerating experimental diabetic healing10.1038/jid.2009.26 ↗
45. Keratinocyte-fibroblast interactions in wound healing10.1038/sj.jid.5700786 ↗
46. Determining the degree of methylesterification of pectin by ATR/FT-IR: methodology optimisation and comparison with theoretical calculations10.1016/j.carbpol.2009.07.003 ↗
47. The stem cell antigen CD34 functions as a regulator of hemopoietic cell adhesion10.1073/pnas.92.26.12240 ↗
48. Preparation of polysaccharides from cyanobacteria Nostoc commune and their antioxidant activities
49. Unusual reversible elastomeric gels from Nostoc commune
50. Multi-stimuli responsive smart chitosan-based microcapsules for targeted drug delivery and triggered drug release10.1016/j.ultsonch.2017.03.011 ↗
51. Treating the chronic wound: a practical approach to the care of nonhealing wounds and wound care dressings.10.1016/j.jaad.2007.08.048 ↗