journal article·2021-05-01

Therapeutic strategies of iron-based nanomaterials for cancer therapy

Xiaqing Wu, Haiyuan Zhang

Biomedical Materials· Volume 16· Issue 3
Publisher page

Abstract

Abstract Iron-based nanomaterials have appeared in various cancer treatments owing to their promising functions and safety. Various sophisticated iron-based nanomaterials have been designed to exhibit great therapeutic effects through different strategies. Given the rapid progression, there is a great need to integrate the recent advances to learn about the latest innovation in this field. In this review, we classified the strategies of iron-based nanomaterials for cancer treatment into the following categories: immunotherapy, ferroptosis, magnetic hyperthermia and magneto-mechanical destruction. On the one hand, we discussed the underlining mechanism of iron-based nanomaterials in these therapies and applications; on the other hand, we analyzed the feasible combination of these applications and other therapies. Finally, the current challenges and expectation of iron-based nanomaterials in this field were highlighted.
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Research context

OpenAlex topics: Nanoparticle-Based Drug Delivery · Nanoplatforms for cancer theranostics · Graphene and Nanomaterials Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References (72)

Show source-provided references
1. Functional nanomaterials for phototherapies of cancer10.1021/cr400532z ↗
2. Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer10.1039/c8cs00618k ↗
3. Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues10.1038/nnano.2016.168 ↗
4. Nanolongan with multiple on-demand conversions for ferroptosis-apoptosis combined anticancer therapy10.1021/acsnano.8b05602 ↗
5. ‘All-in-One’ nanoparticles for trimodality imaging-guided intracellular photo-magnetic hyperthermia therapy under intravenous administration10.1002/adfm.201705710 ↗
6. Remote actuation of magnetic nanoparticles for cancer cell selective treatment through cytoskeletal disruption10.1038/srep33560 ↗
7. Mechanism of cell death induced by magnetic hyperthermia with nanoparticles of γ-MnxFe2−xO3 synthesized by a single step process10.1039/b708156a ↗
8. Biomaterial-assisted targeted modulation of immune cells in cancer treatment10.1038/s41563-018-0147-9 ↗
9. SPION primes THP1 derived M2 macrophages towards M1-like macrophages10.1016/j.bbrc.2013.10.115 ↗
10. Tumor-associated macrophages in cancers10.1007/s12094-015-1373-0 ↗
11. Comprehensive understanding of magnetic hyperthermia for improving antitumor therapeutic efficacy10.7150/thno.40805 ↗
12. The immunotherapeutic effect of Fe3O4 nanoparticles as adjuvants on mice H22 live cancer10.1166/jnn.2010.1591 ↗
13. Enhanced macrophage delivery to the colon using magnetic lipoplexes with a magnetic field10.1080/10717544.2019.1662515 ↗
14. Iron chelated melanin-like nanoparticles for tumor-associated macrophage repolarization and cancer therapy10.1016/j.biomaterials.2019.119515 ↗
15. Janus nanobullets combine photodynamic therapy and magnetic hyperthermia to potentiate synergetic anti-metastatic immunotherapy10.1002/advs.201901690 ↗
16. Engineering magnetosomes for ferroptosis/immunomodulation synergism in cancer10.1021/acsnano.9b00892 ↗
17. Nanomaterial-induced ferroptosis for cancer specific therapy10.1016/j.ccr.2018.12.015 ↗
18. Development of a novel FePt-based multifunctional ferroptosis agent for high-efficiency anticancer therapy10.1039/C8NR05150J ↗
19. Tumor microenvironment-triggered aggregated magnetic nanoparticles for reinforced image-guided immunogenic chemotherapy10.1002/advs.201802134 ↗
20. Magnetic nanoparticles in cancer therapy and diagnosis10.1002/adhm.201901058 ↗
21. Theranostic magnetic nanoparticles10.1021/ar200085c ↗
22. Controlled cell death by magnetic hyperthermia: effects of exposure time, field amplitude, and nanoparticle concentration10.1007/s11095-012-0710-z ↗
23. Towards nanomedicines of the future: remote magneto-mechanical actuation of nanomedicines by alternating magnetic fields10.1016/j.jconrel.2015.09.038 ↗
24. Immunomodulating nanomedicine for cancer therapy10.1021/acs.nanolett.8b02340 ↗
25. An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice10.1172/JCI44490 ↗
26. Iron reduces M1 macrophage polarization in RAW264.7 macrophages associated with inhibition of STAT110.1155/2017/8570818 ↗
27. Iron trafficking and metabolism in macrophages: contribution to the polarized phenotype10.1016/j.it.2011.03.007 ↗
28. In vitro inhibition of tumor growth by low-dose iron oxide nanoparticles activating macrophages10.1177/0885328218817939 ↗
29. Artificially reprogrammed macrophages as tumor-tropic immunosuppression-resistant biologics to realize therapeutics production and immune activation10.1002/adma.201807211 ↗
30. Myeloid-derived suppressor cell membrane-coated magnetic nanoparticles for cancer theranostics by inducing macrophage polarization and synergizing immunogenic cell death10.1002/adfm.201801389 ↗
31. Spontaneously formed porous structure and M1 polarization effect of Fe3O4 nanoparticles for enhanced antitumor therapy10.1016/j.ijpharm.2019.01.048 ↗
32. Nanoscale metal-organic framework overcomes hypoxia for photodynamic therapy primed cancer immunotherapy10.1021/jacs.8b01072 ↗
33. Iron nanoparticles for low-power local magnetic hyperthermia in combination with immune checkpoint blockade for systemic antitumor therapy10.1021/acs.nanolett.9b00579 ↗
34. Polarization of tumor-associated macrophage phenotype via porous hollow iron nanoparticles for tumor immunotherapy in vivo10.1039/C9NR06505A ↗
35. Effect of surface charge and particle size on gel structure of aluminum hydroxycarbonate gel10.1002/jps.2600710111 ↗
36. IgE synthesis in man. II. Comparison of tetanus and diphtheria IgE antibody in allergic and nonallergic children10.1016/0091-6749(79)90124-6 ↗
37. Modified Fe3O4 magnetic nanoparticle delivery of CpG inhibits tumor growth and spontaneous pulmonary metastases to enhance immunotherapy10.1186/s11671-018-2661-8 ↗
38. NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis10.1016/j.redox.2019.101107 ↗
39. A mini-review and perspective on ferroptosis-inducing strategies in cancer therapy10.1016/j.cclet.2019.03.025 ↗
40. Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs10.1016/j.canlet.2020.02.015 ↗
41. Regulation of ferroptotic cancer cell death by GPX410.1016/j.cell.2013.12.010 ↗
42. Emerging strategies of cancer therapy based on ferroptosis10.1002/adma.201704007 ↗
43. pH-responsive, self-sacrificial nanotheranostic agent for potential in vivo in vitro dual modal MRI/CT imaging, real-time, and in situ monitoring of cancer therapy10.1021/acs.bioconjchem.6b00562 ↗
44. Activatable singlet oxygen generation from lipid hydroperoxide nanoparticles for cancer therapy10.1002/anie.201701181 ↗
45. Synthesis of iron nanometallic glasses and their application in cancer therapy by a localized Fenton reaction10.1002/anie.201510031 ↗
46. Tumor microenvironment-activatable Fe-doxorubicin preloaded amorphous CaCO3 nanoformulation triggers ferroptosis in target tumor cells10.1126/sciadv.aax1346 ↗
47. Ultrasound-induced reactive oxygen species mediated therapy and imaging using a Fenton reaction activable polymersome10.1021/acsnano.5b06175 ↗
48. Recent progress in ferroptosis inducers for cancer therapy10.1002/adma.201904197 ↗
49. Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition10.1038/nature24297 ↗
50. Enhanced ferroptosis by oxygen-boosted phototherapy based on a 2-in-1 nanoplatform of ferrous hemoglobin for tumor synergistic therapy10.1021/acsnano.9b09426 ↗
51. Polypeptide-based theranostics with tumor-microenvironment-activatable cascade reaction for chemo-ferroptosis combination therapy10.1021/acsami.0c03748 ↗
52. Mesoporous polydopamine carrying sorafenib and SPIO nanoparticles for MRI-guided ferroptosis cancer therapy10.1016/j.jconrel.2020.01.048 ↗
53. Switching apoptosis to ferroptosis: metal-organic network for high-efficiency anticancer therapy10.1021/acs.nanolett.6b04060 ↗
54. Metal–phenolic network-based nanocomplexes that evoke ferroptosis by apoptosis: promoted nuclear drug influx and reversed drug resistance of cancer10.1021/acs.chemmater.9b03042 ↗
55. Platelet membrane-camouflaged magnetic nanoparticles for ferroptosis-enhanced cancer immunotherapy10.1002/smll.202001704 ↗
56. Nanoparticle ferritin-bound erastin and rapamycin: a nanodrug combining autophagy and ferroptosis for anticancer therapy10.1039/C9BM00653B ↗
57. Magnetic nanoparticle-based cancer therapy10.1088/1674-1056/22/2/027506 ↗
58. Magnetic-Fe/Fe3O4-nanoparticle-bound SN38 as carboxylesterase-cleavable prodrug for the delivery to tumors within monocytes/macrophages10.3762/bjnano.3.51 ↗
59. Injectable magnetic supramolecular hydrogel with magnetocaloric liquid-conformal property prevents post-operative recurrence in a breast cancer model10.1016/j.actbio.2018.04.052 ↗
60. ROS self-generation and hypoxia self-enhanced biodegradable magnetic nanotheranostics for targeted tumor therapy10.1039/C9NH00490D ↗
61. Enhanced tumor synergistic therapy by injectable magnetic hydrogel mediated generation of hyperthermia and highly toxic reactive oxygen species10.1021/acsnano.9b06134 ↗
62. Duality of iron oxide nanoparticles in cancer therapy: amplification of heating efficiency by magnetic hyperthermia and photothermal bimodal treatment10.1021/acsnano.5b07249 ↗
63. Iron oxide nanoflowers @ CuS hybrids for cancer tri-therapy: interplay of photothermal therapy, magnetic hyperthermia and photodynamic therapy10.7150/thno.30238 ↗
64. Ferrimagnetic vortex nanoring-mediated mild magnetic hyperthermia imparts potent immuno-logical effect for treating cancer metastasis10.1021/acsnano.9b01979 ↗
65. Magnetic nanorods for remote disruption of lipid membranes by non-heating low frequency magnetic field10.1016/j.nano.2019.102065 ↗
66. Magnetic-assisted treatment of liver fibrosis10.3390/cells8101279 ↗
67. Aptamer-conjugated superparamagnetic ferroarabinogalactan nanoparticles for targeted magnetodynamic therapy of cancer10.3390/cancers12010216 ↗
68. Targeting a G-protein-coupled receptor overexpressed in endocrine tumors by magnetic nanoparticles to induce cell death10.1021/nn404954s ↗
69. Lysosomal membrane permeabilization by targeted magnetic nanoparticles in alternating magnetic fields10.1021/nn40074048 ↗
70. Remote control of mechanical forces via mitochondrial-targeted magnetic nanospinners for efficient cancer treatment10.1002/smll.201905424 ↗
71. Remote control of cellular behaviour with magnetic nanoparticles10.1038/nnano.2008.39 ↗
72. Biofu-nctionalized magnetic-vortex microdiscs for targeted cancer-cell destruction10.1038/nmat2591 ↗