Architectural Design of Biomaterial Scaffolds for Hematopoietic Stem Cell Culture
Source abstract
Abstract
Recently, biomaterials have been developed for ex vivo expansion of hematopoietic stem cells (HSCs). HSCs exist in highly specialized niches in the bone marrow and are extremely sensitive to their microenvironment; therefore, this review focuses on the architecture of biomaterials and its effects on HSC culture. Herein, we describe the chemical and physical components of the HSC’s niche that can be used to inform the design of biomaterials. We then summarize the effects of surface topography, structural properties, and chemical composition of biomaterials on HSC culture. Subsequently, we identify the gaps and challenges in HSC culture, informing the potential future directions that studying HSC culture on biomaterials can take.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Biomedical and Engineering Education
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Integrative Engineering, Chung-Ang University, Seoul, Republic of Korea.
Funding
Ministry of Science and ICT, South Korea · Chung-Ang University
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