DataVXBiomaterials ResearchPaper
journal article·2025-01Open access

Injectable Brain Extracellular Matrix Hydrogels Enhance Neuronal Migration and Functional Recovery After Intracerebral Hemorrhage

Jiajie Xia, Xinjie Gao, Jun Yao, Yuchao Fei, Dagang Song, Zhiwei Gu, Gang Zheng, Yuxiang Gu, Chuanjian Tu

Biomaterials Research· Volume 29
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Source abstract

Abstract

Neural repair within the lesion cavity caused by intracerebral hemorrhage (ICH) remains a major therapeutic challenge. Hydrogels hold great potential in regenerative medicine as functional scaffolds. However, inadequate host cell infiltration and suboptimal delivery methods have limited their application in tissue engineering. Here, we describe an optimized decellularization approach to create injectable brain extracellular matrix (ECM) hydrogels for the treatment of ICH. The hydrogel exhibits excellent biodegradability and biocompatibility. In an ICH rat model, the hydrogel implanted into the stroke cavity promoted neural recovery, facilitated cell recruitment, enhanced angiogenesis, and inhibited inflammation in the peri-cavity region at 14 d post-implantation. Furthermore, the hydrogel improved cell proliferation and migration, reversed cell apoptosis, and modulated transcriptomic changes in vitro. Notably, the hydrogel may promote neuronal migration and neural functional recovery after ICH through the slit guidance ligand 2–receptor roundabout guidance receptor 1 (Slit2-Robo1) signaling pathway. These findings highlight the potential of brain ECM hydrogels as a promising strategy for brain tissue regeneration.
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Research context

PolymersBiomaterials

OpenAlex topics: Intracerebral and Subarachnoid Hemorrhage Research · Tissue Engineering and Regenerative Medicine · Intracranial Aneurysms: Treatment and Complications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China.

Department of Neurosurgery, Shaoxing Central Hospital, The Central Affiliated Hospital, Shaoxing University, Shaoxing, Zhejiang 312030, China.

Department of Neurosurgery of Huashan Hospital, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, and Institutes of Brain Science, Fudan University, Shanghai 200000, China.

Department of Orthopedic Surgery, Shaoxing Central Hospital, The Central Affiliated Hospital, Shaoxing University, Shaoxing, Zhejiang 312030, China.

Department of Neurosurgery, Shaoxing Central Hospital, China Medical University, Shaoxing, Zhejiang 312030, China.

Funding

Zhejiang Natural Science Fund · Zhejiang Health and Pharmaceutical Science and Technology Plan · Zhejiang Medical Association Clinical Research Fund Project · Science and technology project of Zhejiang Association of Rehabilitation Medicine · Shaoxing Health and Wellness Technology Plan

References (45)

Show source-provided references
1. 10.1001/jama.2019.241310.1001/jama.2019.2413 ↗
2. 10.1016/S1474-4422(21)00252-010.1016/S1474-4422(21)00252-0 ↗
3. 10.1016/S1474-4422(12)70104-710.1016/S1474-4422(12)70104-7 ↗
4. 10.1016/S0140-6736(20)31179-X10.1016/S0140-6736(20)31179-X ↗
5. 10.2214/ajr.129.4.68110.2214/ajr.129.4.681 ↗
6. 10.1016/S1474-4422(05)70283-010.1016/S1474-4422(05)70283-0 ↗
7. 10.1016/j.actbio.2021.04.01710.1016/j.actbio.2021.04.017 ↗
8. 10.1016/j.biomaterials.2012.10.06210.1016/j.biomaterials.2012.10.062 ↗
9. 10.1038/s41467-021-24775-510.1038/s41467-021-24775-5 ↗
10. 10.1155/2016/639782010.1155/2016/6397820 ↗
11. 10.1089/ten.tea.2013.018610.1089/ten.tea.2013.0186 ↗
12. 10.1016/j.ijpharm.2016.12.02810.1016/j.ijpharm.2016.12.028 ↗
13. 10.1016/j.jconrel.2024.02.01710.1016/j.jconrel.2024.02.017 ↗
14. Bae M, Ngo H, Kang YJ, Lee SJ, Park W, Jo Y, Choi YM, Kim JJ, Yi HG, Kim HS, et al. Laminin-augmented decellularized extracellular matrix ameliorating neural differentiation and neuroinflammation in human mini-brains. Small. 2023;20(23): Article e2308815.10.1002/smll.202308815 ↗
15. 10.1016/j.pdpdt.2022.10300810.1016/j.pdpdt.2022.103008 ↗
16. 10.1126/science.114771010.1126/science.1147710 ↗
17. 10.1177/096368971771409010.1177/0963689717714090 ↗
18. 10.1016/j.actbio.2018.09.02010.1016/j.actbio.2018.09.020 ↗
19. 10.1016/j.actbio.2016.11.06810.1016/j.actbio.2016.11.068 ↗
20. 10.3389/fbioe.2020.0078510.3389/fbioe.2020.00785 ↗
21. 10.1016/j.ijpharm.2017.10.01010.1016/j.ijpharm.2017.10.010 ↗
22. 10.1021/acsbiomaterials.8b0160910.1021/acsbiomaterials.8b01609 ↗
23. 10.1016/j.ijpharm.2019.05.07610.1016/j.ijpharm.2019.05.076 ↗
24. 10.1016/j.jconrel.2020.01.02910.1016/j.jconrel.2020.01.029 ↗
25. 10.1016/j.bioadv.2022.21274310.1016/j.bioadv.2022.212743 ↗
26. 10.1007/s12975-023-01189-710.1007/s12975-023-01189-7 ↗
27. 10.1021/acsami.0c1143310.1021/acsami.0c11433 ↗
28. 10.1007/s12975-019-00721-y10.1007/s12975-019-00721-y ↗
29. 10.1021/acsbiomaterials.1c0003010.1021/acsbiomaterials.1c00030 ↗
30. 10.1002/adfm.20230385310.1002/adfm.202303853 ↗
31. 10.3171/2012.8.JNS11215210.3171/2012.8.JNS112152 ↗
32. 10.1161/STROKEAHA.107.50891110.1161/STROKEAHA.107.508911 ↗
33. 10.2174/187152731131203001410.2174/1871527311312030014 ↗
34. 10.1089/ten.tea.2012.062210.1089/ten.tea.2012.0622 ↗
35. 10.1016/j.actbio.2017.09.01110.1016/j.actbio.2017.09.011 ↗
36. 10.1016/j.actbio.2015.08.04010.1016/j.actbio.2015.08.040 ↗
37. 10.1016/j.biomaterials.2016.03.01410.1016/j.biomaterials.2016.03.014 ↗
38. 10.3390/ijms1905136210.3390/ijms19051362 ↗
39. 10.3390/ijms2216854310.3390/ijms22168543 ↗
40. 10.1182/blood-2010-01-26450710.1182/blood-2010-01-264507 ↗
41. 10.1016/j.cell.2022.09.00410.1016/j.cell.2022.09.004 ↗
42. 10.1007/s11064-016-2072-010.1007/s11064-016-2072-0 ↗
43. 10.1126/sciadv.aav061810.1126/sciadv.aav0618 ↗
44. 10.1089/ten.tea.2010.072410.1089/ten.tea.2010.0724 ↗
45. 10.1016/j.biomaterials.2012.01.04410.1016/j.biomaterials.2012.01.044 ↗