Endothelial Dysfunction in Atherosclerosis: Experimental Models and Therapeutics
Source abstract
Abstract
Atherosclerosis is a cardiovascular disease that involves complex and multifactorial processes that are instigated from endothelial dysfunctions. In this review, we address endothelial dysfunction in atherosclerosis and the mechanisms, where they are characterized by structural and functional alterations in endothelial cells (ECs), as caused by inflammation, oxidative stress, or disturbed shear stress. In particular interest, we provide a comprehensive overview of the experimental models (in vitro and in vivo) used to investigate endothelial dysfunction, specifically the role of ECs in atherosclerosis. Finally, current therapeutics, for example, pharmacological interventions, cell and gene therapies, and nanomedicine, are introduced, along with emerging technologies for advanced treatment of atherosclerosis. This review will help readers better understand current scientific findings, experimental models, and technologies in an effort to decipher the mechanisms of atherosclerosis and to advance therapeutic interventions.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Atherosclerosis and Cardiovascular Diseases
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Center for Biomaterials, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.
Division of Bio-Medical Science and Technology, KIST School, University of Science and Technology (UST), Seoul 02792, Republic of Korea.
Funding
Ministry of Science and ICT, South Korea
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