Osseointegration-Related Exosomes for Surface Functionalization of Titanium Implants
Source abstract
Abstract
Despite that the clinical application of titanium-based implants has achieved great success, patients’ own diseases and/or unhealthy lifestyle habits often lead to implant failure. Many studies have been carried out to modify titanium implants to promote osseointegration and implant success. Recent studies showed that exosomes, proactively secreted extracellular vesicles by mammalian cells, could selectively target and modulate the functions of recipient cells such as macrophages, nerve cells, endothelial cells, and bone marrow mesenchymal stem cells that are closely involved in implant osseointegration. Accordingly, using exosomes to functionalize titanium implants has been deemed as a novel and effective way to improve their osseointegration ability. Herein, recent advances pertaining to surface functionalization of titanium implants with exosomes are analyzed and discussed, with focus on the role of exosomes in regulating the functions of osseointegration-related cells, and their immobilization strategies as well as resultant impact on osseointegration ability.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Extracellular vesicles in disease · RNA Interference and Gene Delivery · Dendrimers and Hyperbranched Polymers
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Materials Science and Engineering, Jinzhong University, Jinzhong 030619, China.
Shanxi Key Laboratory of Biomedical Metal Materials, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
Funding
Four “Batches” Innovation Project of Invigorating Medical through Science and Technology of Shanxi Province · Shanxi Province Science and Technology Innovation Young Talents Team for Lightweight Material Modification and Application · Natural Science Foundation of Shanxi Province
References (100+)
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