Waste-to-resource: Extraction and transformation of aquatic biomaterials for regenerative medicine
Source abstract
Abstract
The fisheries and aquaculture industry are known for generating substantial waste or by-products, often underutilized, or relegated to low-value purposes. However, this overlooked segment harbors a rich repository of valuable bioactive materials of which have a broad-spectrum of high-value applications. As the blue economy gains momentum and fisheries expand, sustainable exploitation of these aquatic resources is increasingly prioritized. In this review, we present a comprehensive overview of technology-enabled methods for extracting and transforming aquatic waste into valuable biomaterials and their recent advances in regenerative medicine applications, focusing on marine collagen, chitin/chitosan, calcium phosphate and bioactive-peptides. We discuss the inherent bioactive qualities of these "waste-to-resource" aquatic biomaterials and identify opportunities for their use in regenerative medicine to advance healthcare while achieving the Sustainable Development Goals.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Protein Hydrolysis and Bioactive Peptides · Aquaculture Nutrition and Growth · Collagen: Extraction and Characterization
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (100+)
Show source-provided references
1. 2022
2. OECD · 2021
3. Green processing of seafood waste biomass towards blue economy10.1016/j.crsust.2022.100164 ↗
4. Fish industry waste: treatments, environmental impacts, current and potential uses10.1111/j.1365-2621.2006.01513.x ↗
5. Nutrient recovery and recycling from fishery waste and by-products10.1016/j.jenvman.2023.119266 ↗
6. Valorisation of fish by-products against waste management treatments — comparison of environmental impacts10.1016/j.wasman.2015.08.017 ↗
7. Trends in fisheries waste utilization: a valuable resource of nutrients and valorized products for the food industry
8. Hydroxyapatite recovery from fish byproducts for biomedical applications10.1016/j.scp.2022.100726 ↗
9. Health benefits and food applications of bioactive compounds from fish byproducts: a review10.1016/j.jff.2017.06.034 ↗
10. Seafood discards: a potent source of enzymes and biomacromolecules with nutritional and nutraceutical significance10.3389/fnut.2022.879929 ↗
11. Crustacean waste biorefinery as a sustainable cost-effective business model10.1016/j.cej.2022.135937 ↗
12. Collagen, protein hydrolysates and chitin from by-products of fish and shellfish: an overview10.1016/j.heliyon.2023.e14937 ↗
13. Impact of different ultrasound-assisted processes for preparation of collagen hydrolysates from Asian bullfrog skin on characteristics and antioxidative properties10.1016/j.ultsonch.2022.106163 ↗
14. Sustainable food waste management towards circular bioeconomy: policy review, limitations and opportunities10.1016/j.biortech.2019.122497 ↗
15. Principles, drivers and opportunities of a circular bioeconomy10.1038/s43016-021-00340-7 ↗
16. Green and innovative techniques for recovery of valuable compounds from seafood by-products and discards: a review10.1016/j.tifs.2018.12.004 ↗
17. The United Nations
18. 2017
19. Collagen-based biomaterials for biomedical applications10.1002/jbm.b.34881 ↗
20. The collagen suprafamily: from biosynthesis to advanced biomaterial development10.1002/adma.201801651 ↗
21. The triple helix of collagens — an ancient protein structure that enabled animal multicellularity and tissue evolution10.1242/jcs.203950 ↗
22. Fishery wastes as a yet undiscovered treasure from the sea: biomolecules sources, extraction methods and valorization10.3390/md18120622 ↗
23. Jellyfish from fisheries by-catches as a sustainable source of high-value compounds with biotechnological applications10.3390/md20040266 ↗
24. Type I collagen from jellyfish Catostylus mosaicus for biomaterial applications10.1021/acsbiomaterials.7b00979 ↗
25. Impact of extraction condition on the yield and molecular characteristics of collagen from Asian bullfrog (Rana tigerina) skin10.1016/j.lwt.2022.113439 ↗
26. Collagens made from giant salamander (Andrias davidianus) skin and their odorants10.1016/j.foodchem.2021.130061 ↗
27. Recent advances of collagen-based biomaterials: multi-hierarchical structure, modification and biomedical applications
28. Thermostability gradient in the collagen triple helix reveals its multi-domain structure10.1016/j.jmb.2004.03.037 ↗
29. The effect of the subunit composition on the thermostability of collagens from the scales of freshwater fish10.1016/j.foodchem.2012.04.112 ↗
30. Nature designs tough collagen: explaining the nanostructure of collagen fibrils10.1073/pnas.0603216103 ↗
31. Biomedical applications of collagens10.1002/jbm.b.33541 ↗
32. Collagen-based biomaterials for tissue engineering10.1021/acsbiomaterials.2c00730 ↗
33. Characterization of immunogenicity associated with the biocompatibility of type I collagen from tilapia fish skin10.3390/polym14112300 ↗
34. Evaluation of the immunogenicity of a vascular graft covered with collagen derived from the European carp (Cyprinus carpio) and bovine collagen10.1155/2019/5301405 ↗
35. Squid type II collagen as a novel biomaterial: isolation, characterization, immunogenicity and relieving effect on degenerative osteoarthritis via inhibiting STAT1 signaling in pro-inflammatory macrophages10.1016/j.msec.2018.04.021 ↗
36. In vivo analysis of the biocompatibility and immune response of jellyfish collagen scaffolds and its suitability for bone regeneration10.3390/ijms21124518 ↗
37. Sustainable aquaculture side-streams derived hybrid biocomposite for bone tissue engineering10.1016/j.msec.2021.112104 ↗
38. Comparison of physical–chemical properties of type I collagen from different species10.1016/j.foodchem.2005.06.053 ↗
39. Surface modification of PVDF using non-mammalian sources of collagen for enhancement of endothelial cell functionality
40. Structural characterization and in vitro immunogenicity evaluation of amphibian-derived collagen type II from the cartilage of Chinese giant salamander (Andrias davidianus)10.1080/09205063.2020.1786882 ↗
41. Characterization of collagen from jellyfish Aurelia aurita and investigation of biomaterials potentials10.1007/s12010-023-04848-5 ↗
42. Self-assembly study of type I collagen extracted from male Wistar Hannover rat tail tendons10.1186/s40824-020-00197-0 ↗
43. D. Miranda-Nieves, E.L. Chaikof, Collagen and Elastin Biomaterials for the Fabrication of Engineered Living Tissues, (n.d.).
44. Effects of cross-linking on mechanical, biological properties and biodegradation behavior of Nile tilapia skin collagen sponge as a biomedical material10.1016/j.jmbbm.2018.01.006 ↗
45. Jellyfish collagen matrices conserve the chondrogenic phenotype in two- and three-dimensional collagen matrices: jellyfish collagen matrices conserve the chondrogenic phenotype10.1002/term.1993 ↗
46. Cutting edge aquatic-based collagens in tissue engineering10.3390/md21020087 ↗
47. Collagen fibril formation in vitro: from origin to opportunities10.1016/j.mtbio.2022.100322 ↗
48. Sustainable valorisation of seafood by-products: recovery of collagen and development of collagen-based novel functional food ingredients10.1016/j.ifset.2016.03.015 ↗
49. A quantitative comparable study on multi-hierarchy conformation of acid and pepsin-solubilized collagens from the skin of grass carp (Ctenopharyngodon idella)10.1016/j.msec.2018.11.043 ↗
50. Properties of grass carp (Ctenopharyngodon idella) collagen and gel for application in biomaterials10.3390/gels8110699 ↗
51. Isolation, characterization and valorizable applications of fish scale collagen in food and agriculture industries10.1016/j.bcab.2016.06.010 ↗
52. Antioxidant activity of collagen extracts obtained from the skin and gills of Oreochromis sp.10.1089/jmf.2019.0013 ↗
53. Impact of ultrasound on extractability of native collagen from tuna by-product and its ultrastructure and physicochemical attributes10.1016/j.ultsonch.2022.106129 ↗
54. Collagen from Atlantic cod (Gadus morhua) skins extracted using CO2 acidified water with potential application in healthcare10.1007/s10965-020-02048-x ↗
55. Selective extraction of collagen peptides with high purity from cod skins by deep eutectic solvents10.1021/acssuschemeng.7b01439 ↗
56. Uncovering the potential of aqueous solutions of deep eutectic solvents on the extraction and purification of collagen type I from Atlantic codfish (Gadus morhua)10.1039/D1GC01432C ↗
57. Extraction of biocompatible collagen from blue shark skins through the conventional extraction process intensification using natural deep eutectic solvents10.3389/fchem.2022.937036 ↗
58. Improved collagen extraction from jellyfish (Acromitus hardenbergi) with increased physical-induced solubilization processes10.1016/j.foodchem.2017.12.083 ↗
59. Extraction of collagen/gelatin from the marine demosponge Chondrosia reniformis (Nardo, 1847) using water acidified with carbon dioxide — process optimization10.1021/acs.iecr.6b00523 ↗
60. Water and carbon dioxide: green solvents for the extraction of collagen/gelatin from marine sponges10.1021/sc500621z ↗
61. Isolation and characterization of marine-derived collagens and gelatins in the perspective of biomedical application
62. Improving collagen processing towards a greener approach: current progress10.1002/jctb.7332 ↗
63. Deep eutectic solvents: a review of fundamentals and applications10.1021/acs.chemrev.0c00385 ↗
64. A natural deep eutectic solvent (NADES) as potential excipient in collagen-based products10.1016/j.ijbiomac.2020.04.026 ↗
65. Seafood waste as attractive source of chitin and chitosan production and their applications10.3390/ijms21124290 ↗
66. Application of spectroscopic methods for structural analysis of chitin and chitosan10.3390/md8051567 ↗
67. Historical review on chitin and chitosan biopolymers10.1007/s10311-019-00901-0 ↗
68. Evaluation of extracted β-chitosan from Loligo duvauceli for the preparation of tissue engineering scaffolds10.1007/s10924-017-1020-7 ↗
69. Chitin, chitosan, and nanochitin: extraction, synthesis, and applications10.3390/polym14193989 ↗
70. Chitin and chitosan: properties and applications10.1016/j.progpolymsci.2006.06.001 ↗
71. Biomedical potential of β-chitosan from cuttlebone of cephalopods10.1016/j.carbpol.2021.118591 ↗
72. Structural differences between chitin and chitosan extracted from three different marine sources10.1016/j.ijbiomac.2014.01.045 ↗
73. On chemistry of γ-chitin10.1016/j.carbpol.2017.08.076 ↗
74. Advanced polymer hydrogels that promote diabetic ulcer healing: mechanisms, classifications, and medical applications10.1186/s40824-023-00379-6 ↗
75. Effect of degree of deacetylation of chitosan/chitin on human neural stem cell culture10.1002/mabi.202200389 ↗
76. pH effects on solubility, zeta potential, and correlation between antibacterial activity and molecular weight of chitosan10.1016/j.carbpol.2015.07.072 ↗
77. Antibacterial activity and mechanism of chitosan with ultra high molecular weight10.1016/j.carbpol.2016.04.025 ↗
78. Intermolecular interactions of chitosan: degree of acetylation and molecular weight10.1016/j.carbpol.2021.117782 ↗
79. A composite sponge based on alkylated chitosan and diatom-biosilica for rapid hemostasis10.1016/j.ijbiomac.2021.05.123 ↗
80. Nonswelling injectable chitosan hydrogel via UV crosslinking induced hydrophobic effect for minimally invasive tissue engineering10.1016/j.carbpol.2020.117143 ↗
81. Bacterial growth-induced tobramycin smart release self-healing hydrogel for Pseudomonas aeruginosa-infected burn wound healing10.1021/acsnano.2c05557 ↗
82. Triple-conjugated photo-/temperature-/pH-sensitive chitosan with an intelligent response for bioengineering applications10.1016/j.carbpol.2022.120066 ↗
83. Antibacterial activity of N,O-acylated chitosan derivative10.3390/polym13010107 ↗
84. Physicochemical properties and release study of antimetabolite-incorporated stearoyl chitosan10.1021/acsomega.3c05108 ↗
85. Alkylated chitosan nanomaterials for enhanced antimicrobial activity and delivery of fusidic acid: preparation and preliminary in vitro investigation10.1002/app.53990 ↗
86. Sulfonated chitosan and phosphorylated chitosan coated polylactide membrane by polydopamine-assisting for the growth and osteogenic differentiation of MC3T3-E1s10.1016/j.carbpol.2019.115517 ↗
87. Optimization of thiolated chitosan nanoparticles for the enhancement of in vivo hypoglycemic efficacy of sitagliptin in streptozotocin-induced diabetic rats10.3390/pharmaceutics12040300 ↗
88. Tailoring the properties of chitosan by grafting with 2-mercaptobenzoic acid to improve mucoadhesion: in silico studies, synthesis and characterization10.1007/s40204-022-00201-x ↗
89. In-situ forming hydrogel based on thiolated chitosan/carboxymethyl cellulose (CMC) containing borate bioactive glass for wound healing10.1016/j.ijbiomac.2022.09.177 ↗
90. In situ formation of hydrogel wound dressing based on carboxymethyl chitin/tannic acid for promoting skin wound healing10.1021/acsomega.3c06683 ↗
91. Synthesis, characterization and anticoagulant activity of chitosan derivatives10.1016/j.jsps.2019.11.003 ↗
92. Preparation, characterization and antibacterial activity of new ionized chitosan10.1016/j.carbpol.2022.119490 ↗
93. Recent advances in extraction of chitin and chitosan10.1007/s11274-022-03468-1 ↗
94. Green and eco-friendly approaches for the extraction of chitin and chitosan: a review10.1016/j.carbpol.2022.119349 ↗
95. A review on valorization of chitinous waste10.1007/s10965-021-02759-9 ↗
96. The impact of re-ordering the conventional chemical steps on the production and characterization of natural chitosan from biowaste of Black Tiger Shrimp, Penaeus monodon10.1016/j.seares.2022.102306 ↗
97. Rapid and efficient extraction of chitin and chitosan for scale-up production: effect of process parameters on deacetylation degree and molecular weight10.1016/j.ijbiomac.2019.08.079 ↗
98. Microwave-assisted deep eutectic solvent extraction of chitin from crayfish shell wastes for 3D printable inks10.1016/j.indcrop.2023.116325 ↗
99. Versatile acid base sustainable solvent for fast extraction of various molecular weight chitin from lobster shell10.1016/j.carbpol.2018.08.059 ↗
100. Chitin extraction from shrimp shell using enzymatic treatment. Antitumor, antioxidant and antimicrobial activities of chitosan10.1016/j.ijbiomac.2014.06.013 ↗