Construction of targeted delivery system for curcumin loaded on magnetic α-Fe2O3/Fe3O4 heterogeneous nanotubes and its apoptosis mechanism on MCF-7 cell
Source abstract
Abstract
In this work, the magnetic α-Fe2O3/Fe3O4 heterogeneous nanotubes were successfully prepared by solvent hydrothermal-controlled calcination method. The effects of additive concentration, hydrothermal temperature and time on morphology of products were investigated. The α-Fe2O3/Fe3O4 nanotubes with a saturation magnetization of 50 emu/g were prepared calcinated at 600 °C for 4 h using 0.8 g of glucose. Their average length, the outer and inner diameters were around 240 nm, 178 nm and 145 nm, respectively. The α-Fe2O3/Fe3O4 heterogeneous nanotubes coated with water-soluble liposome were applied for targeted delivery of curcumin. The release of curcumin inside the hollow structure of the nanocomposites could be triggered and effectively sustained represented a process of slow release. The encapsulation efficiency of curcumin in the α-Fe2O3/Fe3O4-CUR@LIP nanocomposites reached 82.1 ± 0.9%. MTT assays demonstrated that blank carriers had excellent biocompatibility and application of magnetic field significantly elevated the cytotoxicity of α-Fe2O3/Fe3O4-CUR@LIP nanocomposites on MCF-7 cell. Electrochemical experiment and Prussian blue staining indicated that the α-Fe2O3/Fe3O4@LIP nanocomposites could aggregate in cells to promote the internalization of curcumin. Magnetic α-Fe2O3/Fe3O4-CUR@LIP nanocomposites and curcumin enhanced the expression of reactive oxygen species in MCF-7 cells and induced apoptosis by fluorescence detection. Flow cytometry and western blot verified that the α-Fe2O3/Fe3O4@LIP nanocomposites under magnetic field enhanced cells late-apoptosis by adjusting the expression of apoptosis-related proteins.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Curcumin's Biomedical Applications · Graphene and Nanomaterials Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (68)
Show source-provided references
1. Curcumin promotes cancer-associated fibroblasts apoptosis via ROS-mediated endoplasmic reticulum stress10.1016/j.abb.2020.108613 ↗
2. Mechanism of anti-cancer activity of curcumin on androgen-dependent and androgen-independent prostate cancer10.3390/nu12030679 ↗
3. The therapeutic potential of curcumin in alleviating N-diethylnitrosamine and iron nitrilotriacetate induced renal cell tumours in mice via inhibition of oxidative stress: implications for cancer chemoprevention10.1016/j.biopha.2021.111636 ↗
4. Anti-angiogenic activity of curcumin in cancer therapy: a narrative review10.2174/1570161116666180209113014 ↗
5. Induction of apoptosis by extract of persian gulf marine mollusk, turbo coronatus through the ROS-mediated mitochondrial targeting on human epithelial ovarian cancer cells
6. Bone marrow mesenchymal stem cells could reduce the toxic effects of hexavalent chromium on the liver by decreasing endoplasmic reticulum stress-mediated apoptosis via SIRT1/HIF-1 alpha signaling pathway in rats10.1016/j.toxlet.2019.04.007 ↗
7. Casticin inhibits growth and enhances ionizing radiation-induced apoptosis through the suppression of STAT3 signaling cascade10.1002/jcb.28259 ↗
8. Single cell analysis for elucidating cellular uptake and transport of cobalt curcumin complex with detection by time-resolved ICPMS10.1016/j.aca.2019.03.062 ↗
9. The protective role of curcumin in myocardial ischemia–reperfusion injury10.1002/jcp.26848 ↗
10. Curcumin ameliorates mercuric chloride-induced liver injury via modulating cytochrome P450 signaling and Nrf2/HO-1 pathway10.1016/j.ecoenv.2020.111426 ↗
11. The role of curcumin in aging and senescence: molecular mechanisms10.1016/j.biopha.2020.111119 ↗
12. The signaling pathways and targets of traditional Chinese medicine and natural medicine in triple-negative breast cancer10.1016/j.jep.2020.113249 ↗
13. Extraction, purification and applications of curcumin from plant materials-a comprehensive review10.1016/j.tifs.2021.04.015 ↗
14. Chitosan-based nanocarriers for encapsulation and delivery of curcumin: a review10.1016/j.ijbiomac.2021.02.216 ↗
15. Recent advances to improve curcumin oral bioavailability10.1016/j.tifs.2021.02.006 ↗
16. Research progress of in-situ gelling ophthalmic drug delivery system
17. Cur-loaded magnetic ZnFe2O4@mZnO-ox-p-g-C3N4 composites as dual pH- and ultrasound responsive nano-carriers for controlled and targeted cancer chemotherapy10.1016/j.matchemphys.2021.124863 ↗
18. Corrigendum: tissue-engineered nerve grafts using a scaffold-independent and injectable drug delivery system: a novel design with translational advantages10.1088/1741-2552/abd1ec ↗
19. Unique flower-like cur-metal complexes loaded liposomes for primary and metastatic breast cancer therapy10.1016/j.msec.2020.111835 ↗
20. A novel pH-sensitive and magnetic starch-based nanocomposite hydrogel as a controlled drug delivery system for wound healing10.1016/j.polymdegradstab.2020.109255 ↗
21. Rifampin and cis-2-decenoic acid co-entrapment in solid lipid nanoparticles as an efficient nano-system with potent anti-biofilm activities
22. Development of an albumin decorated lipid-polymer hybrid nanoparticle for simultaneous delivery of methotrexate and conferone to cancer cells10.1016/j.ijpharm.2021.120421 ↗
23. Chemo-immunotherapy with doxorubicin prodrug and erythrocyte membrane-enveloped polymer nano-vaccine enhances antitumor activity10.1016/j.biopha.2020.110377 ↗
24. The key role of processing in tuning nonlinear viscoelastic properties and microwave absorption in CNT-based polymer nanocomposites
25. A facile approach for elimination of electroneutral/anionic organic dyes from water using a developed carbon-based polymer nanocomposite membrane10.1007/s11270-020-04483-4 ↗
26. Photo- and pH-responsive polycarbonate block copolymer prodrug nanomicelles for controlled release of doxorubicin10.1002/mabi.202000118 ↗
27. Laser-responsive polymeric nanomicelles to subdue tumor multidrug resistance based on mild photodynamic therapy and chemotherapy10.1021/acsanm.0c01148 ↗
28. An impedance biosensor based on magnetic nanobead net and MnO2 nanoflowers for rapid and sensitive detection of foodborne bacteria10.1016/j.bios.2020.112800 ↗
29. Magnetic particle targeting for diagnosis and therapy of lung cancers10.1016/j.jconrel.2020.09.017 ↗
30. Experimental and theoretical study for miR-155 detection through resveratrol interaction with nucleic acids using magnetic core-shell nanoparticles10.1007/s00604-020-04447-9 ↗
31. Complex factors and challenges that affect the pharmacology, safety and efficacy of nanocarrier drug delivery systems10.3390/pharmaceutics13010114 ↗
32. Magnetic nanoparticles applied in targeted therapy and magnetic resonance imaging: crucial preparation parameters, indispensable pre-treatments, updated research advancements and future perspectives10.1039/D0TB00552E ↗
33. Carbon black induced DNA damage and conformational changes to mouse hepatocytes and DNA molecule: a combined study using comet assay and multi-spectra methods10.1016/j.ecoenv.2018.12.044 ↗
34. Vesicle-like structure of lipid-based nanoparticles as drug delivery system revealed by molecular dynamics simulations10.1016/j.ijpharm.2019.01.036 ↗
35. Curcumin-loaded magnetic nanoparticles for breast cancer therapeutics and imaging applications
36. Curcumin-conjugated magnetic nanoparticles for detecting amyloid plaques in Alzheimer's disease mice using magnetic resonance imaging (MRI)10.1016/j.biomaterials.2014.12.005 ↗
37. Evaluation of multilayer coated magnetic nanoparticles as biocompatible curcumin delivery platforms for breast cancer treatment10.1039/C5RA13838H ↗
38. Impact of curcumin on toll-like receptors10.1002/jcp.28103 ↗
39. β-cyclodextrin-folate functionalized poly(lactic-co-glycolide)-superparamagnetic ytterbium ferrite hybrid nanocarrier for targeted delivery of camptothecin
40. Magnetic one-step purification of his-tagged protein by bare iron oxide nanoparticles10.1021/acsomega.8b03348 ↗
41. Improved delivery system for celastrol-loaded magnetic Fe3O4/Fe2O3 heterogeneous nanorods: HIF-1α-related apoptotic effects on SMMC-7721 cell10.1016/j.msec.2021.112103 ↗
42. Delivery of apigenin-loaded magnetic Fe2O3/Fe3O4@mSiO2 nanocomposites to A549 cells and their antitumor mechanism10.1016/j.msec.2020.111719 ↗
43. Immobilization and characterization of cellulase on hydroxy and aldehyde functionalized magnetic Fe2O3/Fe3O4 nanocomposites prepared via a novel rapid combustion process10.1016/j.ijbiomac.2020.06.209 ↗
44. Curcumin drug delivery by vanillin-chitosan coated with calcium ferrite hybrid nanoparticles as carrier10.1016/j.ejps.2018.01.023 ↗
45. Natural biodegradable polymers based nano-formulations for drug delivery: a review10.1016/j.ijpharm.2019.03.011 ↗
46. Covalent immobilization and characterization of penicillin G acylase on magnetic Fe2O3/Fe3O4 heterostructure nanoparticles prepared via a novel solution combustion and gel calcination process10.1016/j.ijbiomac.2020.07.283 ↗
47. Magnetic nanocarriers: evolution of spinel ferrites for medical applications10.1016/j.cis.2019.01.003 ↗
48. A facile urea hydrolysis-calcination process for the preparation of α-Fe2O3 nanoparticles and α-Fe2O3 nanorods and their fabrication mechanisms
49. Therapeutic and diagnostic potential of nanomaterials for enhanced biomedical applications10.1016/j.colsurfb.2019.05.008 ↗
50. Preparation of magnetic Ni0.5Zn0.5Fe2O4/ZnO nanocomposites and their photocatalytic performances for methylene blue in aqueous solution10.1166/jnn.2020.18876 ↗
51. Codelivery of plasmid and curcumin with mesoporous silica nanoparticles for promoting neurite outgrowth10.1021/acsami.9b02797 ↗
52. pH triggered curcumin release and antioxidant activity of curcumin loaded gamma-Fe2O3 magnetic nanoparticles10.1016/j.matlet.2018.04.008 ↗
53. A novel hydrothermal approach for synthesizing α-Fe2O3, γ-Fe2O3 and Fe3O4 mesoporous magnetic nanoparticles10.1016/j.matchemphys.2015.05.073 ↗
54. Design and fabrication of novel multi-targeted magnetic nanoparticles for gene delivery to breast cancer cells10.1016/j.jddst.2020.102151 ↗
55. Preparation and photocatalytic activity of TiO2 nanotube arrays prepared on transparent spinel substrate10.1016/j.ceramint.2021.01.160 ↗
56. Comparison of ionic polymers in the targeted drug delivery applications as the coating materials on the Fe3O4 nanoparticles
57. Porous Fe2O3 nanotubes with α-γ phase junction for enhanced charge separation and photocatalytic property produced by molecular layer deposition10.1016/j.apcatb.2019.02.029 ↗
58. Hydrothermal synthesis, morphology, magnetic properties and self-assembly of hierarchical α-Fe2O3 (hematite) mushroom-, cube- and sphere-like superstructures10.1016/j.apsusc.2018.06.224 ↗
59. Thermal decomposition fabrication, growth mechanism, and characterization of rod-like γ-Fe2O310.1080/15533174.2013.797440 ↗
60. Facile one-step fabrication of magnetite particles under mild hydrothermal conditions10.1016/j.jmmm.2014.10.176 ↗
61. Synthesis and characterization of a novel magnetic carrier with its composition of Fe3O4/carbon using hydrothermal reaction10.1016/j.jmmm.2005.09.044 ↗
62. Shape-controlled fabrication of magnetite silver hybrid nanoparticles with high performance magnetic hyperthermia10.1016/j.biomaterials.2017.01.043 ↗
63. Pharmaceutical feasibility and flow characteristics of polymeric non-spherical particles10.1016/j.nano.2019.03.002 ↗
64. Biotransformations of magnetic nanoparticles in the body10.1016/j.nantod.2015.10.001 ↗
65. Mechanism of fabrication and nano-mechanical properties of α-lactalbumin/chitosan and BSA/κ-carrageenan nanotubes through layer-bylayer assembly for curcumin encapsulation and determination of in vitro cytotoxicity10.1016/j.foodhyd.2019.02.040 ↗
66. A biological magnetic nano-hydrogel based on basil seed mucilage: study of swelling ratio and drug delivery
67. Preparation of magnetic microgels based on dextran for stimuli-responsive release of doxorubicin10.1016/j.jmmm.2020.167394 ↗
68. The iron oxide/polymer nanocomposites for targeted drug delivery and toxicity investigation on zebra fish (Danio rerio)10.1016/j.inoche.2021.108447 ↗