Bifunctional cellulose nanocrystal-MoS2 nanosheets for NIR–activated fluid management and antibacterial protection in wound microenvironments
Source abstract
Abstract
Responsive wound dressings that operate on the responsive mechanism of "external light stimulation-material photothermal conversion-local microenvironment regulation" are key for protecting wound surfaces, promoting healing, and providing antibacterial effects. This work presents an intercalated structure of cellulose nanocrystals (CNCs)/MoS2 nanosheets through an innovative "exfoliation-functionalization" strategy. Additionally, CNC-MoS2 nanosheets serve as highly effective photothermal fillers in polylactic acid (PLA) membranes for wound dressing. These membranes demonstrate excellent UV-blocking capabilities, superior moisture absorption, and good breathability. Remarkably, the membrane with 7 wt% CNC-MoS2 achieves a 400% increase in moisture absorption, with a water vapor transmission rate (WVTR) of 1025 g/m2/day. The membranes also demonstrate excellent photothermal conversion capacity: under irradiation at 2 W/cm2, the surface temperature of the membrane with a 7 wt% CNC-MoS2 content increases by 25.8 °C. It remains stable in phosphate-buffered saline (PBS), demonstrating its potential for use in photothermal therapy within moist wound environments. Upon exposure to near-infrared (NIR) laser irradiation, the hybrid membrane exhibits enhanced antibacterial activity, resulting in 3 mm inhibition zones for both E. coli and S. aureus. The cell biocompatibility reaches 99.5% and migration rate reaches 51.2% after 24 h with NIR. This study provides a strategy for developing responsive wound dressings, offering an innovative solution for complex wound care.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Wound Healing and Treatments · Electrospun Nanofibers in Biomedical Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (56)
Show source-provided references
1. Hair follicles modulate skin barrier function10.1016/j.celrep.2024.114347 ↗
2. Fiber/hydrogel hybrid wound dressing based on eggshell membrane containing postbiotic ingredients10.1016/j.bioadv.2024.214004 ↗
3. Nanomedicine and advanced technologies for burns: preventing infection and facilitating wound healing10.1016/j.addr.2017.08.001 ↗
4. Surface wrinkled microsphere enhanced irregular wound healing through synergistic hygroscopicity, reversible wet-adhesion and antibacterial properties10.1002/smsc.202300216 ↗
5. Mechanoactive wound dressing using poly(N-isopropyl acrylamide) based hydrogels10.1016/j.eurpolymj.2023.112645 ↗
6. Antibacterial and hemostatic bilayered electrospun nanofibrous wound dressings based on quaternized silicone and quaternized chitosan for wound healing10.1016/j.eurpolymj.2021.110733 ↗
7. An in vitro and in vivo study of PCL/chitosan electrospun mat on polyurethane/propolis foam as a bilayer wound dressing. Biomaterials
8. Dual-crosslinked injectable polysaccharide-based hydrogel with synergistic photothermal-controlled release of black phosphorus-baicalein for accelerating wound healing
9. Multifunctional mats by antimicrobial nanoparticles decoration for bioinspired smart wound dressing solutions10.1016/j.msec.2021.111954 ↗
10. Recent advances in smart hydrogels derived from polysaccharides and their applications for wound dressing and healing10.1016/j.biomaterials.2025.123134 ↗
11. 3D printed and smart alginate wound dressings with pH-responsive drug and nanoparticle release10.1016/j.cej.2024.152117 ↗
12. Engineering injectable Coassembled hydrogel by Photothermal driven chitosan-stabilized MoS2 Nanosheets for infected wound healing10.1021/acsnano.4c08883 ↗
13. The versatile nanocomposite wound dressing with zinc replenishment, and enhanced photothermal and fluorescent performance for accelerating methicillin-resistant Staphylococcus aureus-infected diabetic wound repair and indicating dressing replacement10.1016/j.jcis.2025.137867 ↗
14. Optical nano-agents in the second near-infrared window for biomedical applications10.1039/C8CS00494C ↗
15. cis-silicon phthalocyanine conformation endows J-aggregated nanosphere with unique near-infrared absorbance and fluorescence enhancement: a tumor sensitive phototheranostic agent with deep tissue penetrating ability10.1039/D0TB00192A ↗
16. Light-triggered in situ gelation of hydrogels using 2D molybdenum disulfide (MoS2) Nanoassemblies as crosslink epicenter10.1002/adma.202101238 ↗
17. Electrospun PCL/MoS2 nanofiber membranes combined with NIR-triggered Photothermal therapy to accelerate bone regeneration10.1002/smll.202104747 ↗
18. Self-assembled NIR-responsive MoS2@quaternized chitosan/nanocellulose composite paper for recyclable antibacteria10.1016/j.jhazmat.2022.128896 ↗
19. Intercalation and exfoliation chemistries of transition metal dichalcogenides10.1039/D0TA03727C ↗
20. Mechanochemical engineering and supramolecular reconstruction of MoS2 nanosheets with C60-γCD complexes for enhanced photocatalytic and piezoelectric performances10.1016/j.cej.2024.157688 ↗
21. Tannic acid-assisted green exfoliation and functionalization of MoS2 nanosheets: significantly improve the mechanical and flame-retardant properties of polyacrylonitrile composite fibers10.1016/j.cej.2019.123288 ↗
22. Moisture wicking textiles with hydrophilic oriented polyacrylonitrile layer: enabling ultrafast directional water transport10.1016/j.jcis.2023.04.140 ↗
23. Starch-fiber foaming biodegradable composites with polylactic acid hydrophobic surface10.1016/j.ijbiomac.2024.131406 ↗
24. A multifunctional hydrogel with mild photothermal antibacterial and antioxidant properties based on quercetin and dopamine-coated zinc oxide nanoparticles for healing bacteria-infected wound
25. Macroscopic preparation of polylactic acid/graphene composite fiber film with efficient antibacterial and thermal properties10.1002/app.56178 ↗
26. An experimental study on characterization and properties of nano lubricant containing cellulose nanocrystal (CNC)10.1016/j.ijheatmasstransfer.2018.11.041 ↗
27. Waterproof fabric with copper ion-loaded multicompartmental nanoparticle coatings for jellyfish repellency10.3390/pharmaceutics18010047 ↗
28. Synergistic effects of radical distributions of soluble and insoluble polymers within electrospun nanofibers for an extending release of Ferulic acid10.3390/polym16182614 ↗
29. Versatility of electrospun Janus wound dressings10.1080/17435889.2024.2446139 ↗
30. Electrospun tri-layer Core-sheath Nanofibrous coating for sequential treatment of postoperative complications in orthopedic implants10.1002/smll.202505523 ↗
31. Electrospun multi-chamber nanostructures for sustainable biobased chemical nanofibers10.1016/j.nxmate.2024.100119 ↗
32. Functionalized cellulose nanocrystals-MoS2 nanosheets to tailor brick–mortar architecture of green composite for next-generation electronic packaging10.1016/j.cej.2024.156328 ↗
33. Binary strengthening and toughening of MXene/cellulose nanofiber composite paper with nacre-inspired structure and superior electromagnetic interference shielding properties10.1021/acsnano.8b00997 ↗
34. Intumescent flame-retardant cotton produced by tannic acid and sodium hydroxide10.1016/j.jaap.2017.06.003 ↗
35. Simple process to produce high-yield cellulose nanocrystals using recyclable citric/hydrochloric acids10.1021/acssuschemeng.8b05526 ↗
36. Exfoliated MoS2 Nanosheet/cellulose nanocrystal flexible composite films as electrodes for zinc batteries10.1021/acsanm.3c00543 ↗
37. Preparation and thermostability of cellulose nanocrystals and nanofibrils from two sources of biomass: Rice straw and poplar wood10.1007/s10570-019-02683-8 ↗
38. Comparative study between sulfurized MoS2 from molybdenum and molybdenum trioxide precursors for thin-film device applications10.1021/acsami.3c00824 ↗
39. Oxidation of molybdenum disulfide sheet in water under in situ atomic force microscopy observation10.1021/acs.jpcc.7b01863 ↗
40. High-performance nanogenerators based on flexible cellulose nanofibril/MoS2 nanosheet composite piezoelectric films for energy harvesting10.1016/j.nanoen.2020.105541 ↗
41. Needleless electrospinning of a chitosan lactate aqueous solution: influence of solution composition and spinning parameters10.3390/technologies8010002 ↗
42. Impact of entanglement density on solution electrospinning: a phenomenological model for Fiber diameter10.1021/acs.macromol.6b00519 ↗
43. NIR responsive electrospun composite membranes for on-demand delivery of ag ions to enhance treatment of bacteria-infected wounds10.1016/j.cej.2025.163428 ↗
44. Tunable diameter of electrospun fibers using empirical scaling laws of electrospinning parameters10.1016/j.matchemphys.2024.130009 ↗
45. Study of the dextrose equivalent of maltodextrins in electrospinning using an ethanol/water mixture as the electrospinning solvent10.1016/j.foodhyd.2023.108498 ↗
46. Constructing novel biobased phosphorus-containing oligomeric lactates toward synchronously enhancing the toughness and fire safety of poly(lactic acid)10.1021/acssuschemeng.4c01160 ↗
47. Developing a cerium lactate antibacterial nucleating agent for multifunctional polylactic acid packaging film10.1016/j.ijbiomac.2022.08.082 ↗
48. Nucleation and property enhancement mechanism of robust and high-barrier PLA/CNFene composites with multi-level reinforcement structure10.1016/j.compscitech.2023.110364 ↗
49. Developing phase change materials for thermal energy storage using polyols with cold crystallization property10.1016/j.est.2025.115364 ↗
50. Synergistic photodynamic and Photothermal antibacterial activity of in situ grown bacterial cellulose/MoS2-chitosan nanocomposite materials with visible light illumination10.1021/acsami.1c08178 ↗
51. Engineering environmentally friendly nanofiber membranes with superhydrophobic surface and intrapore interfaces for ultrafast oil-water separation10.1016/j.seppur.2023.123885 ↗
52. MoS2/cellulose-doped ZnO nanorods for catalytic, antibacterial and molecular docking studies10.1039/D1NA00648G ↗
53. Molybdenum disulfide regulates the transformation of antibiotic resistance genes under simulated light/dark conditions: role of bacterial oxidative stress and metabolic reprogramming10.1016/j.jece.2025.120265 ↗
54. Designing multi-functional MoS2/rGO piezocatalysts based on bacteria-catalyst topological interactions and electron pump effects for efficient water disinfection10.1016/j.jclepro.2024.142597 ↗
55. Study on synergistic mechanism of molybdenum disulfide/sodium carboxymethyl cellulose composite nanofiber mats for photothermal/photodynamic antibacterial treatment10.1016/j.ijbiomac.2024.130838 ↗
56. Synergistic antimicrobial packaging film with photothermal-controlled biocatalytic capability for tangerine preservation10.1016/j.foodhyd.2024.110832 ↗