Antibacterial self-fused supramolecular polymer hydrogel for infected wound healing
Source abstract
Abstract
Abstract Wound treatment is a huge challenge for healthcare systems, especially when the wound suffered infection. Therefore, it is essential to develop materials with antibacterial properties for wound repair. Herein, we integrated antimicrobial peptides with self-healing hydrogel for infectious wound treatment. The synthetic hydrogel was made by polymerizing N-acryloyl glycinamide (NAGA) monomers and doped with antimicrobial peptide Polymyxin E. Additionally, because of the bisamide structure of the side chains of the NAGA monomers, the hydrogen bond was formed and caused the supramolecular structure. The resulted hydrogel showed excellent self-healing property, biocompatibility, and antimicrobial property, which allowed it to be used as hydrogel dressing. In vivo experiment demonstrated that the hydrogel had the significant capability in promoting infectious wound healing. Therefore, this type of antibacterial self-healing supramolecular hydrogel is expected to serve as infectious wound dressing for medical healthcare applications.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Antimicrobial agents and applications · Antimicrobial Peptides and Activities · Polydiacetylene-based materials and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (43)
Show source-provided references
1. Tough adhesives for diverse wet surfaces10.1126/science.aah6362 ↗
2. Bioinspired mechanically active adhesive dressings to accelerate wound closure10.1126/sciadv.aaw3963 ↗
3. Shark tooth-inspired microneedle dressing for intelligent wound management10.1021/acsnano.1c06279 ↗
4. Artificial spider silk based programmable woven textile for efficient wound management10.1002/adfm.202107707 ↗
5. Multifunctional injectable hydrogel dressings for effectively accelerating wound healing: enhancing biomineralization strategy10.1002/adfm.202100093 ↗
6. Dual-dynamic-bond cross-linked antibacterial adhesive hydrogel sealants with on-demand removability for post-wound-closure and infected wound healing10.1021/acsnano.1c00204 ↗
7. A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing10.1038/s41467-021-21964-0 ↗
8. Tannic acid-reinforced methacrylated chitosan/methacrylated silk fibroin hydrogels with multifunctionality for accelerating wound healing10.1016/j.carbpol.2020.116689 ↗
9. A shear-thinning adhesive hydrogel reinforced by photo-initiated crosslinking as a fit-to-shape tissue sealant10.1039/C9TB01521C ↗
10. Dissolving candlelit microneedle for chronic inflammatory skin diseases10.1002/advs.202004873 ↗
11. Novel porous three-dimensional nanofibrous scaffolds for accelerating wound healing10.1016/j.cej.2019.03.091 ↗
12. Green synthesis and incorporation of sericin silver nanoclusters into electrospun ultrafine cellulose acetate fibers for anti-bacterial applications10.3390/polym13091411 ↗
13. Anisotropic structural color particles from colloidal phase separation10.1126/sciadv.aay1438 ↗
14. Multiple stimuli-responsive mxene-based hydrogel as intelligent drug delivery carriers for deep chronic wound healing10.1002/smll.202104368 ↗
15. Self-healing polysaccharide-based injectable hydrogels with antibacterial activity for wound healing10.1016/j.carbpol.2021.118770 ↗
16. Starch functionalized biodegradable semi-IPN as a pH-tunable controlled release platform for memantine10.1016/j.ijbiomac.2016.11.055 ↗
17. Polysaccharide and poly(methacrylic acid) based biodegradable elastomeric biocompatible semi-IPN hydrogel for controlled drug delivery10.1016/j.msec.2018.06.034 ↗
18. Strength self-healable antibacterial and anti-inflammatory supramolecular polymer hydrogel10.1002/marc.201600695 ↗
19. An in situ-forming polyzwitterion hydrogel: towards vitreous substitute application10.1016/j.bioactmat.2021.02.029 ↗
20. Polypeptide self-assembled nanoparticles as delivery systems for polymyxins B and E10.3390/pharmaceutics12090868 ↗
21. Phloretin potentiates polymyxin E activity against gram-negative bacteria10.1016/j.lfs.2021.120085 ↗
22. Polymyxin derivatives as broad-spectrum antibiotic agents10.1039/C9CC06908A ↗
23. Designing a transparent and fluorine containing hydrogel10.3390/gels7020043 ↗
24. Microfluidics-assisted assembly of injectable photonic hydrogels toward reflective cooling10.1002/smll.201903939 ↗
25. Development of natural-drugs-based low-molecular-weight supramolecular gels10.3390/gels7030105 ↗
26. Engineering tough metallosupramolecular hydrogel films with kirigami structures for compliant soft electronics10.1002/smll.202103836 ↗
27. A novel mechanical robust, self-healing and shape memory hydrogel based on PVA reinforced by cellulose nanocrystal10.1016/j.matlet.2019.126884 ↗
28. Photo-responsive supramolecular hyaluronic acid hydrogels for accelerated wound healing10.1016/j.jconrel.2020.04.014 ↗
29. An injectable, self-healing, electroconductive extracellular matrix-based hydrogel for enhancing tissue repair after traumatic spinal cord injury10.1016/j.bioactmat.2021.05.039 ↗
30. Biomimetic enzyme cascade reaction system in microfluidic electrospray microcapsules10.1126/sciadv.aat2816 ↗
31. Assessment of spinal tumor treatment using implanted 3D-printed vertebral bodies with robotic stereotactic radiotherapy10.1016/j.xinn.2020.100040 ↗
32. Magneto-driven gradients of diamagnetic objects for engineering complex tissues10.1002/adma.202005030 ↗
33. Responsive janus structural color hydrogel micromotors for label-free multiplex assays10.34133/2021/9829068 ↗
34. A novel hydrogel-based treatment for complete transection spinal cord injury repair is driven by microglia/macrophages repopulation10.1016/j.biomaterials.2020.119830 ↗
35. Architecting functionalized carbon microtube/carrollite nanocomposite demonstrating significant microwave characteristics10.1038/s41598-021-91370-5 ↗
36. Investigation of size and medium effects on antimicrobial properties by CuCr2O4 nanoparticles and silicone rubber or PVDF10.1088/2053-1591/ab26cd ↗
37. Biomimetic synthesis, characterization and antibacterial efficacy of ZnO and Au nanoparticles using echinacea flower extract precursor10.1088/2053-1591/aac05f ↗
38. Prominent antibacterial effect of sub 5 nm Cu nanoparticles/MoS2composite under visible light10.1088/1361-6528/ac3577 ↗
39. Novel chitosan hydrogels reinforced by silver nanoparticles with ultrahigh mechanical and high antibacterial properties for accelerating wound healing10.1016/j.ijbiomac.2018.07.060 ↗
40. Antibacterial characteristics of CuS nanoplates anchored onto g-C3N4 nanosheets, suspended in PMMA matrix
41. Nanocellulose-mediated electroconductive self-healing hydrogels with high strength, plasticity, viscoelasticity, stretchability, and biocompatibility toward multifunctional applications10.1021/acsami.8b09656 ↗
42. Carbon black-induced detrimental effect on osteoblasts at low concentrations: Remarkably compromised differentiation without significant cytotoxicity10.1016/j.ecoenv.2019.04.029 ↗
43. Preparation of self-healing hydrogel toward improving electromagnetic interference shielding and energy efficiency10.1038/s41598-021-95683-3 ↗