journal article·2016-09-01

Furfuryl methacrylate plasma polymers for biomedical applications

Hanieh Safizadeh Shirazi, Nicholas Rogers, Andrew Michelmore, Jason D. Whittle

Biointerphases· Volume 11· Issue 3
Publisher page

Abstract

Furfuryl methacrylate (FMA) is a promising precursor for producing polymers for biomedical and cell therapy applications. Herein, FMA plasma polymer coatings were prepared with different powers, deposition times, and flow rates. The plasma polymer coatings were characterized using atomic force microscopy (AFM), scanning electron microscopy (SEM), x-ray photoelectron spectroscopy (XPS), and time-of-flight secondary ion mass spectrometry (ToF-SIMS). The results from AFM and SEM show the early growth of the coatings and the existence of particle aggregates on the surfaces. XPS results indicated no measureable chemical differences between the deposited films produced under different power and flow rate conditions. ToF-SIMS analysis demonstrated differing amounts of C5H5O (81 m/z) and C10H9O2 (161 m/z) species in the coatings which are related to the furan ring structure. Through judicious choice of plasma polymerization parameters, the quantity of the particle aggregates was reduced, and the fabricated plasma polymer coatings were chemically uniform and smooth. Primary human fibroblasts were cultured on FMA plasma polymer surfaces to determine the effect of surface chemical composition and the presence of particle aggregates on cell culture. Particle aggregates were shown to inhibit fibroblast attachment and proliferation.
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Research context

OpenAlex topics: Surface Modification and Superhydrophobicity · Polymer Surface Interaction Studies · Electrospun Nanofibers in Biomedical Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

University of South Australia Future Industries Institute, , Mawson Lakes, Adelaide, South Australia 5095, Australia and , Mawson Lakes, South Australia 5095, Australia

Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM) Future Industries Institute, , Mawson Lakes, Adelaide, South Australia 5095, Australia and , Mawson Lakes, South Australia 5095, Australia

University of South Australia Future Industries Institute, , Mawson Lakes, Adelaide, South Australia 5095, Australia ; , Mawson Lakes, South Australia 5095, Australia ; and School of Engineering, , Mawson Lakes, Adelaide, South Australia 5095, Australia

Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM) Future Industries Institute, , Mawson Lakes, Adelaide, South Australia 5095, Australia ; , Mawson Lakes, South Australia 5095, Australia ; and School of Engineering, , Mawson Lakes, Adelaide, South Australia 5095, Australia

Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM) , Mawson Lakes, South Australia 5095, Australia and School of Engineering, , Mawson Lakes, Adelaide, South Australia 5095, Australia

University of South Australia , Mawson Lakes, South Australia 5095, Australia and School of Engineering, , Mawson Lakes, Adelaide, South Australia 5095, Australia

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