Al2TiO5–Al2O3–TiO2 nanocomposite: Structure, mechanical property and bioactivity studies

Abstract Novel biomaterials are of prime importance in tissue engineering. Here, we developed novel nanostructured Al 2 TiO 5 –Al 2 O 3 –TiO 2 composite as a biomaterial for bone repair. Initially, nanocrystalline Al 2 O 3 –TiO 2 composite powder was synthesized by a sol–gel process. The powder was cold compacted and sintered at 1300–1500 °C to develop nanostructured Al 2 TiO 5 –Al 2 O 3 –TiO 2 composite. Nano features were retained in the sintered structures while the grains showed irregular morphology. The grain-growth and microcracking were prominent at higher sintering temperatures. X-ray diffraction peak intensity of β-Al 2 TiO 5 increased with increasing temperature. β-Al 2 TiO 5 content increased from 91.67% at 1300 °C to 98.83% at 1500 °C, according to Rietveld refinement. The density of β-Al 2 TiO 5 sintered at 1300 °C, 1400 °C and 1500 °C were computed to be 3.668 g cm −3 , 3.685 g cm −3 and 3.664 g cm −3 , respectively. Nanocrystalline grains enhanced the flexural strength. The highest flexural strength of 43.2 MPa was achieved. Bioactivity and biomechanical properties were assessed in simulated body fluid. Electron microscopy confirmed the formation of apatite crystals on the surface of the nanocomposite. Spectroscopic analysis established the presence of Ca and P ions in the crystals. Results throw light on biocompatibility and bioactivity of β-Al 2 TiO 5 phase, which has not been reported previously.