Silver tungstate-loaded alginate films for broad-spectrum antimicrobial and antiviral applications
Source abstract
Abstract
Silver tungstate (Ag2WO4) particles (0–5% w/w) were synthesized and homogeneously incorporated into calcium alginate films. The composites preserved structural and thermal stability while showing improved mechanical strength. The alginate matrix promoted a phase transition from orthorhombic α-Ag2WO4 to metastable cubic γ-Ag2WO4, linked to superior antimicrobial activity. Ag2WO4 addition reduced film hydrophilicity and swelling by ~30% and enhanced elasticity and tensile strength. The 5% composite exhibited strong antibacterial activity, with 98.56% inhibition against Pseudomonas aeruginosa, 99.81% against MRSA, and 99.54% against Mycobacterium smegmatis. Antiviral assays with bacteriophage phi6 (a SARS-CoV-2 surrogate) demonstrated 97.93% inactivation after 30 min and complete inactivation after 24 h. Importantly, the 2.5% Ag2WO4 sample showed no cytotoxicity. The antimicrobial action was attributed to reactive oxygen species generation and Ag⁺ion release, which compromise microbial structures and functions. These findings highlight Ag2WO4-loaded alginate films as promising antimicrobial and antiviral biomaterials.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced Nanomaterials in Catalysis · Advanced Drug Delivery Systems
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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