Superparamagnetic core@shell nanocomposites of cerium-doped ferrite nanoparticles@silica as multifunctional systems for magnetic hyperthermia and controlled delivery of antineoplastic drugs

In this study, we synthesized cerium-doped ferrite nanoparticles (Ce 0.3 Fe 2.7 O 4 NPs-OA) and coated them with silica (Ce 0.3 Fe 2.7 O 4 NPs@SiO 2 ). We characterized the nanocomposites using XRD, FTIR, VSM, and TEM. Additionally, we evaluated their heating capacity under an AMF to assess their performance in hyperthermic conditions. Finally, we investigated their potential as drug-delivery systems through in vitro loading and release studies of doxorubicin (DOX) at pH 7.4 and 5, and we evaluated the in vitro cytotoxicity in the 1132SK human fibroblast cell line. The results confirmed the successful synthesis of superparamagnetic and biocompatible nanocomposites with a core@shell structure. Moreover, these systems demonstrated significant potential for combined hyperthermia and controlled delivery of antineoplastic drugs.