Preparation and characterization of temperature-sensitive hydrogels loaded with cerium-based metal-organic framework nanoczymes

Cerium-based metal-organic framework (Ce-MOF) nanozyme-loaded N-isopropylacrylamide thermosensitive composite hydrogels are promising for clinical wound healing owing to their antioxidant potential. Ce-MOF nanozyme synthesized via hydrothermal method had a particle size of 125 ± 1.2 nm and zeta potential of −25 ± 1.2 mV, which were then loaded into the thermosensitive hydrogel. The composite hydrogel exhibited a swelling degree of 1575.36 ± 75.45%, low hemolysis rates (1.84 ± 0.50% for Ce-MOF, 3.77 ± 1.58% for the composite) and good cell compatibility. Verified by rheological testing, SEM and swelling experiments, it possessed favorable physicochemical properties and excellent antioxidant activity via effective free radical scavenging. This safe and effective composite hydrogel serves as a novel auxiliary material for wound healing, holding broad clinical application prospects.