Recommended solutions for the disinfection of Ti-Zr-Cu-Pd bulk metallic glasses

Disinfection of medical devices is crucial to patient safety. However, an incorrect selection of disinfectant can damage the material surface and impact its performance. Ti-Zr-Cu-Pd bulk metallic glasses (BMGs) show considerable potential for biomedical use, however standard sterilisation protocols remain undeveloped. This study evaluates the effects of common clinical disinfection solutions, including NaOH, NaClO, and Virkon®, on Ti-Zr-Cu-Pd BMGs, to assess their impact on surface characteristics (chemical composition, surface free energy) and on biocompatibility (pre-osteoblast cells behaviour). The findings aim to inform practical guidelines for safe and effective cleaning and sterilisation of devices that contain these alloys. • BMGs are now used as medical devices and need disinfection in surgical settings. • Cleaning routines with generic solutions can be inappropriate and damage substrates. • Disinfection protocols are undeveloped for TiZrCuPd Bulk Metallic Glasses. • Non-chlorinated disinfectants are recommended for TiZrCuPd BMGs. • Commercial grade hydroxides or hypochlorites are strongly discouraged.