journal article·2021-03-01

Lubricin as a tool for controlling adhesion in vivo and ex vivo

Clayton S. Manasa, Saimon M. Silva, Pauline E. Desroches, Jessair Dennaoui, Mathew J. Russo, Mingyu Han, Anita F. Quigley, George W. Greene, Robert M. I. Kapsa, Simon E. Moulton

Biointerphases· Volume 16· Issue 2
Publisher page

Abstract

The ability to prevent or minimize the accumulation of unwanted biological materials on implantable medical devices is important in maintaining the long-term function of implants. To address this issue, there has been a focus on materials, both biological and synthetic, that have the potential to prevent device fouling. In this review, we introduce a glycoprotein called lubricin and report on its emergence as an effective antifouling coating material. We outline the versatility of lubricin coatings on different surfaces, describe the physical properties of its monolayer structures, and highlight its antifouling properties in improving implant compatibility as well as its use in treatment of ocular diseases and arthritis. This review further describes synthetic polymers mimicking the lubricin structure and function. We also discuss the potential future use of lubricin and its synthetic mimetics as antiadhesive biomaterials for therapeutic applications.
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Research context

OpenAlex topics: Polymer Surface Interaction Studies · Marine Biology and Environmental Chemistry · Bone Tissue Engineering Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Faculty of Science, Engineering and Technology, Swinburne University of Technology 1 , Melbourne, Victoria 3122, Australia

The Aikenhead Centre for Medical Discovery (ACMD), St Vincent’s Hospital Melbourne 2 , Melbourne, Victoria 3065, Australia

ARC Centre of Excellence for Electromaterials Science, Faculty of Science, Engineering and Technology, Swinburne University of Technology 3 , Melbourne, Victoria 3122, Australia

Institute for Frontier Materials, Deakin University 4 , Melbourne, Victoria 3216, Australia

School of Electrical and Biomedical Engineering, RMIT University 5 , Melbourne, Victoria 3001, Australia

Department of Medicine, St Vincent’s Hospital Melbourne 6 , Fitzroy 3065, Melbourne, Australia

ARC Centre of Excellence for Electromaterials Science, Deakin University 7 , Melbourne, Victoria 3216, Australia

Iverson Health Innovation Research Institute, Swinburne University of Technology 8 , Victoria 3122, Australia

Funding

Australian Reseach Council

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