Soft cluster-induced desorption/ionization mass spectrometry: How soft is soft?
Source abstract
Abstract
Desorption/ionization induced by neutral clusters (DINeC) is used as an ultrasoft desorption/ionization method for the analysis of fragile biomolecules by means of mass spectrometry (MS). As a test molecule, the glycopeptide vancomycin was measured with DINeC-MS, and resulting mass spectra were compared to the results obtained with electrospray ionization (ESI), matrix assisted laser desorption ionization, and time-of-flight secondary ion MS. Of the desorption-based techniques, DINeC spectra show the lowest abundance of fragments comparable to ESI spectra. The soft desorption nature of DINeC was further demonstrated when applied to MS analysis of teicoplanin.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Mass Spectrometry Techniques and Applications · Ion-surface interactions and analysis · Advanced Proteomics Techniques and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Institut für Angewandte Physik and Zentrum für Materialforschung, Justus-Liebig-Universität Giessen 1 , Heinrich-Buff-Ring 16, D-35392 Giessen, Germany
Institut für Physikalische Chemie and Zentrum für Materialforschung, Justus-Liebig-Universität Giessen 2 , Heinrich-Buff-Ring 17, D-35392 Giessen, Germany
Bruker Daltonik GmbH 3 , Fahrenheitstr. 4, D-28359 Bremen, Germany
Funding
HICforFAIR · Helmholtz Graduate School for Hadron and Ion Research · Bundesministerium für Bildung und Forschung
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