Preparation of core-shell magnetic nano-upconversion materials and its targeting effect
Source abstract
Abstract
Abstract In this paper, magnetic upconversion Fe3O4@SiO2@NaGdF4:Yb,Er (UCP) composite particles were prepared by Fe3O4@SiO2-NH2 nanoparticles reacting with NaGdF4:Yb,Er modified by α-bromoisobutyric acid for the first time. The products were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD), EDS and fluorescence spectrum. The results show that UCP composite nanoparticles have upconversion fluorescence emission peaks as NaGdF4:Yb,Er but weaker emission intensity. In contrast to NaGdF4:Yb,Er@Fe3O4 particles, UCP composite nanoparticles have better fluorescence luminescence properties, but poor magnetic properties. Biological distribution and magnetic nano-uptake of radioactive in mouse show nanomagnetic UCP particles loaded with drugs can be accumulated in the tumor site of spleen and pancreas by magnetic controlled targeting, in order to achieve drug magnetic targeted therapy.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Luminescence Properties of Advanced Materials · Atomic and Subatomic Physics Research · Radiation Detection and Scintillator Technologies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (20)
Show source-provided references
1. Upconverting nanoparticles10.1002/anie.201005159 ↗
2. Preparation and biocompatibility of NaYF4: Yb3+/Er3+ upconverted luminescent nanoparticles modified by polyvinylpyrrolidone
3. Recent advances in the chemistry of lanthanide doped upconversion nanocrystals10.1039/b809132n ↗
4. Luminescent rare earth nanomaterials for bioprobe applications10.1039/b805306e ↗
5. Upconversion nanoparticles in biological labeling, imaging, and therapy10.1039/c0an00144a ↗
6. Rare earth fluoride nano/microcrystals: synthesis, surface modification and application10.1039/c0jm00031k ↗
7. Upconversion nanoparticles: synthesis, surface modification and biological applications10.1016/j.nano.2011.02.013 ↗
8. Upconversion spectroscopy and properties of NaYF4 doped with Er3+, Tm3+and / or Yb3+10.1016/j.jlumin.2005.03.011 ↗
9. High quality sodium rare earth fluoride nanocrystals: controlled synthesis and opticalproperties10.1021/ja060212h ↗
10. NaYF4 rare earth reactor concentration crystal phase conversion luminescence10.3788/fgxb20113209.0853 ↗
11. Effect of high temperature annealing on the upconversion of NaYF4: Yb, Er nanoparticles in nitrogen atmosphere
12. Synthesis of NaYF4: Yb3+, Er3+ nanocrystals and their upconversion luminescence assisted by amino phosphoric acid10.3788/fgxb20113207.0675 ↗
13. Synthesis of polyethylenimine NaYF4 nanoparticles with upconversion fluorescence10.1088/0957-4484/17/23/013 ↗
14. Ultrasensitive nanosensors based on upconversion nanoparticles for selective hypoxia imaging in vivo upon near-infrared excitation10.1021/ja5042989 ↗
15. Intelligent MnO2 nanosheets anchored with upconversion nanoprobes for concurrent pH-/H2O2-responsive UCL imaging and oxygen-elevated synergetic therapy10.1002/adma.201405141 ↗
16. Effects of different alcohol water ratio on β-NaYF4: Yb3+, Er3+ crystals
17. Dual-targeting upconversion nanoprobes across the blood-brain barrier for magnetic resonance/fluorescence imaging of intracranial glioblastoma10.1021/nn406197c ↗
18. Ultrasmall NaGdF4 nanodots for efficient MR angiography and atherosclerotic plaque imaging10.1002/adma.201305222 ↗
19. Preparation and biological applications of GO functionalized water-based magnetic fluids10.1166/jnn.2018.13926 ↗
20. Rational design of GO modified Fe3O4/SiO2 nanoparticles with combined Rhenium-188 and Gambogic acid for magnetic target therapy10.1021/acsami.7b07589 ↗