Musa acuminata nanoemulgel: formulation, in vitro kinetics and antimicrobial studies

The study was intended to formulate nanoemulgel from the leaf extract of Musa acuminata. Ethanol and chloroform were used as solvents in the ratio of 1:8 (%w/v). DL-alpha-tocopherol, characterised by gas chromatography mass spectrometry, was identified to be the major component with potential biological activities. Based on a pseudo-ternary plot, the 1:1 S _mix (surfactant:co-surfactant) ratio was optimised as it posed maximum regions of emulsion. The prepared nanoemulgel was evaluated for physical appearance, pH, spreadability and swelling index. The appearance was pale yellowish-white, translucent within a pH range of 5–5.8. Antimicrobial studies were performed against dandruff-causing microbes (Staphylococcus epidermidis and Malassezia furfur). In vitro studies were carried out for optimised formulations of EG2, EG4, CG2 and CG3. The drug release of 94.28% after 12 h with the Higuchi plot of R ² value as 0.99 was observed for EG2. The kinetically optimised formulation, EG2, was found to have a good spreadability of 12.2 (g cm)/s and a swelling index of 64%.